7-keto DHEA
supplement - new
research
and benefits, is this product safe, are there any dangers or safety
issues? Can it be combined with other hormones, prescription and
non-prescription?
Proponents claim that
the benefit of
7-keto DHEA is that it cannot metabolized to active androgenic or estrogenic hormones but retains and enhances the
immune enhancing, memory-enhancing and thermogenic effects similar to that of
DHEA. However, this does not
seem to make much sense. The physiological mechanisms that lead to the benefits
would be similar to those that lead to side effects.
DHEA has
sexual enhancement
properties. We suspect
7-keto has a similar effect. This over the counter hormone has been promoted for weight loss
but we do not think it is a safe way to lose weight.
Benefit
As of 2011 few human studies of any significance have been published. Much more research
needs to be published before we can make any
recommendations.
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Influence on hormones in the body
Q. Regarding your concern that 7 keto DHEA does
follow the pathway allowing for biosynthesis of androgens and estrogens, how
does this reconcile with the following: Ergosteroids: Induction of thermogenic enzymes in liver treated
with steroids derived from dehydoepiandrosterone from Proceedings of the
National Academy of Sciences. H Lardy, B Partridge, N Kneer, V Wei University of
Wisconsin. Most of the findings were self descriptive in the title. However,
they found that the 7 oxo steroids were not convertible to either testosterone
or estrogens. I understand your reasoning, but sometimes what happens is not
consistent with what seems reasonable.
A. Sometimes the best way to tell is to take the supplement
yourself. You may consider trying 25 mg of 7 ketodhea daily for 2 to 4 weeks and
please let us know what effects you notice and we can determine if these effects
are androgenic.
Q. Thank you for your reply; however, I was
already aware of your suggestion. My inquiry was to obtain an opinion regarding
the data submitted from the NAS. Having talked with Dr Lardy, he and his team
are very capable researchers. It would seem to me that a better approach would
be to do an androgen / estrogen baseline followed by a ratio history. Or maybe
even better; a DHEA / cortisol; DHEA / testosterone; testosterone / estrogen
ratio.
A. All these tests are helpful
but they don't reveal what the hormones do within cells in different tissues of
the body. What effect would they have on cardiac nodes and heart rhythm? What
effect do they have on stimulation of cancer cells? What effect would 7 keto
dhea supplements have on mood, alertness, sleep, behavior, aggression, hair
thinning, etc. One has to look at the overall clinical picture from multiple
viewpoints rather than just blood studies.
Prostate gland, BPH, enlarged
prostate
I took 7 Keto for 50 days since my doctor recommended it.
My PSA went from 6.9 to 9.6 in those 50 days. Cause and effect. I stopped it and
after 30 days PSA dropped to 7.9 another 30 days dropped to 6.4.
Sexual enhancement
I find 7-keto dhea helps with sexuality, but I
prefer using a sexual herbs rather than hormones? What about avena sativa or
tribulus, do
these herbs help?
There are several herbs that work well as male and female
enhancers, you can review them at the
impotence page.
I have read several feedbacks from women who
experienced very apparent sexual identity changes after using 7 keto dhea. They
all confirm they have developed strong attraction to their own sex, do you have
such testimonial or feedback about this. I know dhea levels directly affect
sexual orientation and when dhea is high and testosterone is low female
homosexualism theoretically occur.
Elevation of androgens, whether dhea or testosterone, and even
the use of certain sexual herbs, can increase sexuality
to such an extent that it can make some individuals consider the idea that being
with the same gender can also be a pleasant experience. We are not sure whether
7 keto dhea is any more potent in this area than dhea itself, but androgens, in
general, increase libido which may make a person desire more variety. It is
known that the use of androgens or sex herbs can make some people of the
opposite sex that normally were not appealing to be more desirable. The more
aroused someone is, the more types and genders of people took appealing.
Testosterone influence
I am a 33 year old woman who is trying to
conceive a child. I read 7 Keto DHEA can help with
egg quality, so I started taking 50 mg daily for one week. Then tested my
blood after one week. My testosterone levels (which had been quite low two
months ago) was 324! My DHEA level was 280, slightly up from when it was tested
two months ago. This of course put everything on hold with our fertility plan as
we have to get my testosterone down. I do not have PCOS. I read that 7Keto
doesn't raise sex hormones. But taking the 7Keto DHEA (non
compounded-bought it at Whole Foods) caused my spike. I
also was taking 2 pills of fish oil daily, maca root and vitamin D 5000 iU. Do
you think that my one week of 50 mg a day would cause my
testosterone to be high? If so, how long will it take to flush my body of the
excess? I'm devastated that yet again I have to wait with
the fears that I'll never have a child.
It is not possible for us to know for sure, but it is
likely that this hormone supplement could raise testosterone levels and
stopping it would lower the levels back to where it was, but the time for that
could vary among different people but is usually a few days or 2 or 3 weeks in
most people.
7-keto DHEA for weight loss -
this is a press release sent by Humanetics corporation
The ingredient division of Humanetics Corporation recently announced that
a newly published study in the peer-reviewed Journal of Nutritional Biochemistry
revealed that 7-Keto dhea reverses the decrease in Resting Metabolic Rate (RMR)
normally associated with dieting and increases RMR above basal levels of
overweight adults. RMR is the amount of calories that the body burns while at
rest and accounts for approximately 70% of all calories burned in the average
day. This 5-week, randomized, double-blind, placebo-controlled, crossover trial
of forty-five overweight adults (34 women, 11 men) on a calorie-restricted diet
revealed that the administration of 7-Keto to overweight adults in conjunction
with a calorie-restricted diet safely reversed the decline in RMR normally
associated with dieting. In addition, 7-Keto also demonstrated an ability to
increase RMR above basal levels without any stimulant mode of action and may
benefit overweight and obese individuals with impaired energy expenditure. The
study concluded that 7-Keto DHEA produced a statistically significant increase of
5% increase in RMR and no serious adverse events were encountered during any
of the treatment periods. 7-Keto dhea enhances the activity of three thermogenic enzymes – Glycerol-3-phosphate
dehydrogenase, Malic Enzyme & Fatty Acyl CoA Oxidase. The up-regulation of these
three enzymes results in a higher metabolic rate.
Founded in 1988, Humanetics
Corporation is a privately held corporation that markets 7-Keto® for weight
loss, MicroLactin for inflammation and joint health and Inzitol for glucose
transport and creatine uptake by muscle cells.
Our comments: There are other natural supplements that are helpful
for weight loss, and the
use of hormones should be a last resort since long term hormone use has side
effects.
My health food store manager emailed me this
report. Can you comment on it? "In a recently published article
in Penton Media's Functional Foods & Nutraceuticals, magazine, 7-Keto from
Humanetics Corporation was named by Dr. Mark Tallon as one of the best weight
loss ingredients in the top tier of his efficacy pyramid. "As a scientist I
always ask, show me the data, when it comes to products that claim to influence
weight loss," says Dr. Mark J Tallon, CEO, OxygeniX, Ltd and CR-Technologies,
LLP. "The evidence for such products ranges from extensive to zero. To build
back consumer confidence, we need to begin separating those proven products from
those lacking data," says Dr. Mark Tallon. 7-Keto is a naturally occurring substance produced by the body
in the adrenal glands and its production declines with age. It is a
non-stimulant, thermogenic agent that is clinically proven to increase
metabolism and promote healthy weight loss. 7-Keto works naturally with the body
to enhance the activity of three thermogenic enzymes - Glycerol-3-phosphate
dehydrogenase, Malic Enzyme & Fatty Acyl CoA Oxidase. The up-regulation of these
three key fat burning, thermogenic enzymes promotes weight loss without
stimulants and produces 3 times more weight loss than diet & exercise alone.
We believe the use of hormones for weight loss is a dangerous
approach. Side effects could occur that may not be reversible.
Comparing two hormones
I have just finished reading the
information on your website but the great majority of the information and questions
answers did not address benefits side effects of 7-KETO dhea versus regular DHEA.
It seems that would be very important since the great majority of the side
effects from supplementing with regular DHEA are considered to be caused by an
increase in certain hormone levels, such as, testosterone. 7-KETO dhea,
according to some sources, does not increase that hormone. If the action of regular DHEA is to increase the decreasing
hormone levels of testosterone; thereby, affording the body the benefits of that
hormone, and 7-KETO dhea is known NOT to increase that hormone, then what, if
any, benefits does the latter even have? I am 59 years old and have been taking
25mg Enzymatic Therapy 7-KETO dhea for many years and would not
continue if there were no benefits.
As of 2012, we have not seen any long term human
research with 7-Keto dhea to determine what advantages or disadvantages it has
over DHEA. Many users would like to know more about this hormone,
but unfortunately our knowledge is quite limited. Hormones should only be used
when there is clear necessity or deficiency.
Research study
This article was published in Medical
Hypotheses, a journal that writes about hypotheses that sometimes
are accurate, and other times aren't.
7-oxo-DHEA and Raynaud's phenomenon.
Ihler G, Chami-Stemmann H.
Texas A&M College of
Medicine, College Station, USA.
Patients with Raynaud's phenomenon have abnormal digital vasoconstriction in
response to cold. The pathogenesis remains unknown but may involve a local
neurovascular defect leading to vasoconstriction. Diagnosis of primary Raynaud's
phenomenon is based on typical symptomatology coupled with normal physical
examination, normal laboratory studies and lack of observable pathology by nail
fold capillaroscopy. Secondary Raynaud's phenomenon is known to occur associated
with several connective tissue diseases, vascular injury due to repeated
vibrational trauma, and other causes which produce demonstrable vascular and
microcirculatory damage. Treatment of Raynaud's symptoms is conservative and
aimed at prevention of attacks. Patients are advised to remain warm and, if
possible, to live in warm climates. We suggest that an ergogenic (thermogenic)
steroid, 7-oxo-DHEA, which is available
without prescription as the trademarked 7-keto DHEA, may be very helpful in
prevention of primary Raynaud's attacks by increasing the basal metabolic rate
and inhibiting vasospasm.
Twinlab brand
I bought a bottle of Twinlab 7 keto DHEA. is this product safe to take?
Wondering if this brand offered benefit more than standard hormone
product.
Twinlab is a reliable company therefore it is likely that the
supplement fact panel is accurate.
7-OXO-DHEA comparison
I would like to ask if the dihydroxylated
methylcarbonate ester of 7-OXO-DHEA would be a safer alternative? A dietary and wellness supplement currently on the
market now called "Blaze" by S.A.N. contains the dihydroxylated methylcarbonate
ester of 7-OXO-DHEA.
I wonder if this formula would lower the risks of any cardiovascular adverse
events that are being associated with use of 7-Keto DHEA at this time by your
team.
We have not seen any human studies with Blaze by S.A.N. Hence it
is impossible to say whether this form is any better or safer. Hormones have
quite a lot of potential health problems they can cause and should not be used
casually.