7-keto DHEA supplement - Find out  new 7-keto DHEA research and 7-keto benefits

7-keto DHEA is a hormone similar to DHEA. Proponents claim that the benefit of 7-Keto DHEA is that it cannot metabolized to active androgenic or estrogenic hormones but retains and enhances the immunologic, memory-enhancing and thermogenic effects of DHEA. However, this does not seem to make much sense to us.
    DHEA has sexual enhancement properties. We suspect 7-keto DHEA has a similar effect. 7 keto DHEA has been promoted for weight loss.

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7-Keto DHEA benefit
As of August 2007, few human studies of any significance have been published in Medline regarding 7-keto DHEA. Therefore, no recommendations with any confidence can be made at this time. Is 7 keto DHEA preferable to regular DHEA? This is a difficult question to answer. Much more research has been published with DHEA as opposed to 7 keto DHEA. 7-keto DHEA has been promoted for weight loss in some users, but a combination of hoodia, ginger, green tea extract and several other herbs, as found in Diet Rx, is very effective.

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7-keto DHEA for weight loss - this is a press release sent by Humanetics corporation
The ingredient division of Humanetics Corporation recently announced that a newly published study in the peer-reviewed Journal of Nutritional Biochemistry revealed that 7-Keto dhea reverses the decrease in Resting Metabolic Rate (RMR) normally associated with dieting and increases RMR above basal levels of overweight adults. RMR is the amount of calories that the body burns while at rest and accounts for approximately 70% of all calories burned in the average day. This 5-week, randomized, double-blind, placebo-controlled, crossover trial of forty-five overweight adults (34 women, 11 men) on a calorie-restricted diet revealed that the administration of 7-Keto to overweight adults in conjunction with a calorie-restricted diet safely reversed the decline in RMR normally associated with dieting. In addition, 7-Keto also demonstrated an ability to increase RMR above basal levels without any stimulant mode of action and may benefit overweight and obese individuals with impaired energy expenditure. The study concluded that 7-Keto produced a statistically significant increase of 5.4% increase in RMR and no serious adverse events were encountered during any of the treatment periods. To read the entire article, click here.  7-Keto dhea enhances the activity of three thermogenic enzymes – Glycerol-3-phosphate dehydrogenase, Malic Enzyme & Fatty Acyl CoA Oxidase. The up-regulation of these three enzymes results in a higher metabolic rate.
   About Humanetics Corporation: Founded in 1988, Humanetics Corporation is a privately held corporation that markets 7-Keto® for weight loss, MicroLactin for inflammation and joint health and Inzitol for glucose transport and creatine uptake by muscle cells.
   Our comments: There are other natural supplements that are helpful for weight loss, and the use of hormones should be a last resort since long term hormone use has side effects.

7-Keto DHEA Research Update
This article was published in Medical Hypotheses, a journal that writes about hypotheses that sometimes are accurate, and other times aren't.
7-oxo-DHEA and Raynaud's phenomenon.
Ihler G, Chami-Stemmann H.
Texas A&M College of Medicine, College Station 77843, USA.
Patients with Raynaud's phenomenon have abnormal digital vasoconstriction in response to cold. The pathogenesis remains unknown but may involve a local neurovascular defect leading to vasoconstriction. Diagnosis of primary Raynaud's phenomenon is based on typical symptomatology coupled with normal physical examination, normal laboratory studies and lack of observable pathology by nail fold capillaroscopy. Secondary Raynaud's phenomenon is known to occur associated with several connective tissue diseases, vascular injury due to repeated vibrational trauma, and other causes which produce demonstrable vascular and microcirculatory damage. Treatment of Raynaud's symptoms is conservative and aimed at prevention of attacks. Patients are advised to remain warm and, if possible, to live in warm climates. We suggest that an ergogenic (thermogenic) steroid, 7-oxo-DHEA (3-acetoxyandrost-5-ene-7,17-dione), which is available without prescription as the trademarked 7-keto DHEA, may be very helpful in prevention of primary Raynaud's attacks by increasing the basal metabolic rate and inhibiting vasospasm.

7 keto dhea questions
Q. I bought a bottle of Twinlab 7 keto dhea. is this product safe to take? Wondering if Twinlab 7 keto dhea offered benefit more than standard DHEA product.
   A. Twinlab is a reliable company therefore we can most likely be assured that the accuracy of the contents are good. However, we are not certain about the long term safety of 7 keto dhea. There has not been any head to head comparison between dhea and 7 keto dhea to see which form offers more benefit with fewer side effects.

Q. i have recently read your explanation on supplementation with 7-keto DHEA but would like to ask if the dihydroxylated methylcarbonate ester of 7-OXO-DHEA would be a safer alternative to regular straight-up 7-keto DHEA ? A dietary and wellness supplement currently on the market now called "Blaze" by S.A.N. contains the dihydroxylated methylcarbonate ester of 7-OXO-DHEA called "Delta 5-E", 1,2,4,11,12,16-septahydro-10-13-dimethyl-3,17-dimethoxycarboxy-cyclopenta(a)phenanthree-7-one). I wonder if this formula would lower the risks of any cardiovascular adverse events that are being associated with use of 7-Keto DHEA at this time by your team. What do you think?
   A. We have not seen any human studies with Blaze by S.A.N. Hence it is impossible to say whether this form is any better or safer. Hormones have quite a lot of potential health problems they can cause and should not be used casually.

Q. My health food store manager emailed me this report on 7-keto-dhea. Can you comment on it? "In a recently published article in Penton Media's Functional Foods & Nutraceuticals, magazine, 7-Keto from Humanetics Corporation was named by Dr. Mark Tallon as one of the best weight loss ingredients in the top tier of his efficacy pyramid. "As a scientist I always ask, show me the data, when it comes to products that claim to influence weight loss," says Dr. Mark J Tallon, CEO, OxygeniX, Ltd and CR-Technologies, LLP. "The evidence for such products ranges from extensive to zero. To build back consumer confidence, we need to begin separating those proven products from those lacking data," says Dr. Mark Tallon. 7-Keto (3-acetyl-7-oxo dehydroepiandrosterone) is a naturally occurring substance produced by the body in the adrenal glands and its production declines with age. It is a non-stimulant, thermogenic agent that is clinically proven to increase metabolism and promote healthy weight loss. 7-Keto works naturally with the body to enhance the activity of three thermogenic enzymes - Glycerol-3-phosphate dehydrogenase, Malic Enzyme & Fatty Acyl CoA Oxidase. The up-regulation of these three key fat burning, thermogenic enzymes promotes weight loss without stimulants and produces 3 times more weight loss than diet & exercise alone.
   A. We believe the use of hormones for weight loss is a dangerous approach. Side effects could occur that may not be reversible.

Q. I have read several feedbacks from women who experienced very apparent sexual identity changes after using 7 keto dhea. They all confirm they have developed strong attraction to their own sex, do you have such testimonial or feedback about this. I know dhea levels directly affect sexual orientation and when dhea is high and testosterone is low female homosexualism theoretically occur. But since 7 keto dhea doesnt influence dheas levels directly, how can it have such a pronounced effect on brain. Can it be due to upregulation of star protein or enhanced adrenal androgen synthesis due to increased thyroid hormones? Since thyroid hormones trigger synthesis of adrenal neurohormones such as pregnenolone and dhea (dhea-s and preg-s is extremely high in hyperthyroids) can this be the reason why this happens to females who uses 7-keto-dhea.? I have also seen reports of supplemental dhea influencing female sexual identity but 7 keto dhea seems to have stronger effects.
   A. Elevation of androgens, whether dhea or testosterone, and even the use of certain sexual herbs that enhance sexual urge, can increase sexuality to such an extent that it can make some individuals consider the idea that being with the same gender can also be a pleasant experience. We are not sure whether 7 keto dhea is any more potent in this area than dhea itself, but androgens, in general, increase libido which may make a person desire more variety. It is known that the use of androgens or sex herbs can make some people of the opposite sex that normally were not appealing to be more desirable. The more aroused someone is, the more types and genders of people took appealing.

Q. I find 7-keto dhea helps with sexuality, but I prefer using a sexual herbs rather than hormones? What about avena sativa, does this herb help and do you have any info on it?
   A. There are several herbs you can review at this impotence page. For specific avena sativa herb info.

Q. I have just finished reading the information on your website for DHEA. The great majority of the information and questions answers did not address benefits side effects of 7-KETO dhea versus regular DHEA. It seems that would be very important since the great majority of the side effects from supplementing with regular DHEA are considered to be caused by an increase in certain hormone levels, such as, testosterone and 7-KETO dhea, according to reliable sources, does not increase that hormone. You answered one question concerning the limited research with 7-KETO dhea and I assume that’s why your cautions did not sway the reader to that form of DHEA for safer use. Here is my question: If the action of regular DHEA is to increase the decreasing hormone levels of testosterone; thereby, affording the body the benefits of that hormone, and 7-KETO dhea is known NOT to increase that hormone, then what, if any, benefits does 7-KETO dhea even have? I am 59 years old and have been taking 7-KETO dhea for many years (one 25mg Enzymatic Therapy per day) and would not continue if there were no benefits.
   A. As of December 2007, we have not seen any long term human research with 7-Keto dhea to determine what advantages or disadvantages it has over DHEA. Many users of 7-keto dhea would like to know more about this hormone, but unfortunately our knowledge is quite limited. Hormones should only be used when there is clear necessity or deficiency.

Q. Regarding your concern that 7 keto DHEA does follow the pathway allowing for biosynthesis of androgens and estrogens, how does this reconcile with the following:
   Ergosteroids: Induction of thermogenic enzymes in liver treated with steroids derived from dehydoepiandrosterone from Proceedings of the National Academy of Sciences. H Lardy, B Partridge, N Kneer, V Wei University of Wisconsin.
   Most of the findings were self descriptive in the title. However, they found that the 7 oxo steroids were not convertible to either testosterone or estrogens. I understand your reasoning, but sometimes what happens is not consistent with what seems reasonable. As usual, this leaves open a question!
   A. Sometimes the best way to tell is to take the supplement yourself. You may consider trying 25 mg of 7 ketodhea daily for 2 to 4 weeks and please let us know what effects you notice and we can determine if these effects are androgenic.
      Q. Thank you for your reply; however, I was already aware of your suggestion. My inquiry was to obtain an opinion regarding the data submitted from the NAS. Having talked with Dr Lardy, he and his team are very capable researchers. It would seem to me that a better approach would be to do an androgen / estrogen baseline followed by a ratio history. Or maybe even better; a DHEA / cortisol; DHEA / testosterone; testosterone / estrogen ratio.
         A. All these tests are helpful but they don't reveal what the hormones do within cells in different tissues of the body. What effect would they have on cardiac nodes and heart rhythm? What effect do they have on stimulation of cancer cells? What effect would 7 keto dhea supplements have on mood, alertness, sleep, behavior, aggression, hair thinning, etc. One has to look at the overall clinical picture from multiple viewpoints rather than just blood studies.

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