AdvantraZ - Advantra Z review

Advantra-Z is derived from the extract of citrus aurantium, also known as immature bitter orange, known in China as zhi-shi. The use of Advantra Z began in the health industry as an ephedra replacement since the FDA ruled against the over the counter use of ephedra products back in 2004. Advantra Z contains alkaloids which are related to the ephedrine alkaloids and have similar effects on metabolism and breakdown of fat, that is, they increase the metabolic rate, and they also increase the rate of breakdown of stored fat. For more info on ephedra. For natural ways to enhance weight loss. Other herbs that have an effect on appetite or weight loss include hoodia, ginger, green tea extract, spirulina, acetyl-l-carnitine, choline, and several other herbs and nutrients.

Adavantra Z alkaloids
The alkaloids found in Advantra Z include synephrine, hordenine, octopamine, tyramine and N-methyltyramine.

Advantra Z distribution
Advantra Z is distributed by Nutratech with patents issued to Zhishin, llc

Advantra Z side effects
Advantra Z side effects include rapid heart beat, increased body temperature, and some people may experience nausea or irregular heart rhythms. The side effects of Advantra Z could be worsened when combined with other stimulants such as caffeine or certain herbs.

Advantra Z research
Hemodynamic effects of ephedra-free weight-loss supplements in humans.
Am J Med. 2005 Sep;118(9):998-1003. Haller CA, Benowitz NL, Jacob P 3rd. Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, University of California, San Francisco, 94143, USA.
Ephedra-free weight loss dietary supplements containing bitter orange (Citrus aurantium), a botanical source of the adrenergic amines synephrine and octopamine are sold over the counter. These supplements may have some of the health risks associated with ephedra. Our aim was to characterize the pharmacokinetics and cardiovascular effects of C. aurantium dietary supplements. Ten healthy adult nonsmokers participated in a randomized, double-blind, placebo-controlled, three-arm crossover study. Single doses of C. aurantium ( Advantra Z ) containing 46.9 mg synephrine, Xenadrine EFX, a multi-component formulation containing 5.5 mg synephrine, and placebo were administered with a one-week washout. Compared with placebo, Xenadrine EFX but not Advantra Z increased systolic and diastolic blood pressure with peak changes from baseline at 2 hours of 9 Hg systolic, and 9 mm Hg diastolic. Heart rate was increased from baseline at 6 hours compared with placebo (16.7 beats per minute with Xenadrine EFX; 11 beats per minute with Advantra Z,).  Ephedra-free weight loss supplements have significant cardiovascular stimulant actions, similar to ephedra. These effects are not likely caused by C. aurantium alone, because an eightfold higher dose of synephrine (Advantra Z) had no effect on blood pressure, but may be attributable to caffeine and other stimulants in the multi-component formulation.

Advantra Z is a bitter orange extract. A dose of Xenadrine EFX has synephrine and several other ingredients, including caffeine equivalent to the amount in 2 or 3 cups of coffee