food, Diet and Alzheimer's disease
People who eat fish at least once a week have a lower risk of Alzheimer's
disease and lower risk of dementia, but only if they do not carry the gene that
increases the risk of Alzheimer's, called apolipoprotein E4, or ApoE4. Most
people do not carry the ApoE4 gene.
Natural supplements for Alzheimer’s dementia

While scientists have not fully determined the actual causes of Alzheimers
disease, a number of treatment options have been proposed or tried over the years. These
include: Exposure to sunlight and sleep pattern restoration. Therapy with B vitamins
such as B6, folic acid, and B12 that lower homocysteine levels. The use of antioxidants. Providing acetylcholine precursors such as choline. Acetyl-L-carnitine protects against amyloid-beta neurotoxicity
and may be helpful in combination with medicines. You can find
Acetyl-l-Carnitine here. Providing anti-inflammatory agents such as aspirin or ibuprofen. Improving blood flow to brain cells. Mood improvement through nutrients and herbs. Use of
ginkgo biloba. Use of
curcumin,
the yellow compound found in
Turmeric, may be helpful. Mind Power Rx has acetyl-l carnitine and several brain boosting supplement.
Diet and
Alzheimer's disease - reduce your sugar intake
Eating too much sugar could be bad for your brain. Mice bred to develop an
Alzheimer's like disease that were given sugar-sweetened water had a greater
decline in learning skills and memory compared with mice that drank pure water.
The animals that consumed sugar had a greater degree of Alzheimer's-like damage
to their brains.
Mental
exercises for Alzheimer's disease
Doing crossword puzzles and other activities to keep your mind active in old age
reduces the risk of mild cognitive impairment, dementia and the risk of
developing Alzheimer's disease.
Physical exercise to prevent
Alzheimer's disease
People in the early stages of Alzheimer's disease who are more physically
fit have less shrinkage in areas of the brain that are important for memory.
Fitness and exercise slow age-related changes in the brain in healthy people.
People with early Alzheimer's disease are likely to benefit by exercising.
Alpha lipoic acid benefit
A German study showed alpha lipoic acid, a potent antioxidant, was
able to slow the progression of Alzheimer's disease. Patients with Alzheimer's disease received 600 mg of alpha lipoic
acid daily for several years. The researchers concluded that the rate of
progression of the disease was slower in comparison to normal
progression of Alzheimer's disease. A 600 mg dosage is quite high and we
suggest taking not more than 50 mg every other day.
Alzheimer's dementia, phospholipid, and omega-3 fatty acid
levels
Alzheimer's research shows high fish oil intake reduces the risk for dementia.
Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and
Alzheimer disease: the Framingham Heart Study.
Arch Neurol. 2006 Nov;63(11):1545-50. Lipid Metabolism Laboratory, Jean
Mayer US Department of Agriculture Human Nutrition REsearch Center on Aging,
Tuffs University, Boston, MA 02111, USA.
Docosahexaenoic acid (DHA) is an abundant fatty acid in the brain. In the diet,
DHA is found mostly in fatty fish. The content of DHA has been shown to be
decreased in the brain and plasma of patients with dementia. To determine
whether plasma phosphatidylcholine (PC) DHA content is associated with the risk
of developing dementia. A prospective follow-up study in 899 men and women who
were free of dementia at baseline, had a median age of 76.0 years, and were
followed up for a mean of 9.1 years for the development of all-cause dementia
and Alzheimer disease. Subjects in the upper quartile of plasma PC DHA levels
had a mean DHA intake of 0.18 g/d and a mean fish intake of 3.0 servings per
week. The top quartile of plasma PC DHA level was associated with a significant
47% reduction in the risk of developing all-cause dementia in the Framingham
Heart Study.
Exercise for Alzheimer's disease
Nursing home residents with Alzheimer's disease who participate in
a moderate exercise program have a significantly slower deterioration than those
who receive routine medical care.
Family history as risk
factor for Alzheimer's disease
If both parents have Alzheimer's disease, a person is more likely than
other people to get Alzheimer's disease.
Pesticides, environmental
toxins
Exposure to pesticides may have long-term effects on the nervous system,
increasing the risk of Alzheimer’s disease in late life.
Atrial fibrillation cause
Dr. T. Jared Bunch of the Intermountain Medical Center in Murray, Utah, was
quoted at "Heart Rhythm 2009" -- the annual scientific sessions of the Heart
Rhythm Society in Boston, "There has always been a known association between
atrial fibrillation and vascular dementia related to stroke. What is less known
is the association between atrial fibrillation and other dementias, like
Alzheimer's disease." Dr. T. Jared Bunch followed 37,000 patients with a mean
age of 60 years, Twenty seven percent developed atrial fibrillation and 4%
developed dementia during a five-year follow-up period. Patients with dementia
were older and had higher rates of hypertension, coronary heart disease, renal
failure, heart failure and prior strokes. Atrial fibrillation was strongly and
independently associated with all forms of dementia, including Alzheimer's
disease. Patients with atrial fibrillation were much more likely to develop
dementia than those without.
Alzheimer's Dementia Research Update
- New information
Drugs for Alzheimer's
dementia, which pharmaceutical companies and campaigners have lobbied the UK
government to provide to large numbers of elderly patients with dementia across
the country at a cost of over £39m a year, have little effect on their memory
and do not stop the distressing deterioration of their lives, according to an
important study published July 2004. The five-year study, paid for by the NHS
and not the drug companies, found that the drugs are a waste of the scarce
resources available for the condition, said the lead re searcher Roger Gray,
director of Birmingham University's clinical trials unit
Estrogen pills appear to slightly increase the risk of Alzheimer’s disease and other forms of dementia in postmenopausal women, a study found, echoing recent findings involving estrogen-progestin supplements. The findings contradict the long-held belief that estrogen pills can help keep older women’s minds sharp. The results came from a government study called the Women’s Health Initiative and were published in The Journal of the American Medical Association. The research involved nearly 3,000 women, ages 65 to 79, who had had hysterectomies and had taken daily estrogen-only pills, sold by Wyeth Pharmaceuticals as Premarin, for an average of about five years.
2009
Those who receive intravenous immunoglobulin (IVIg) may be at decreased risk for
developing Alzheimer's disease and related neurologic disorders and conditions.
There is interest in using anti-amyloid beta antibodies as a treatment for
Alzheimer's disease, Dr. Jerrold Hill, from the University of Pennsylvania,
Philadelphia treated patients with IVIg which led to decreased levels of amyloid
beta in the serum and cerebrospinal fluid and improved cognition. These
encouraging findings led Dr. Hill's team to find out whether the use of IVIg for
non-Alzheimer's disease indications might provide some degree of protection
against the condition. The researchers compared the development of Alzheimer's
disease and related disorders (ADRD) in 847 subjects treated with IVIg and in
84,700 untreated controls, matched by age, gender, and ADRD risk factors. At 60
months, the ADRD rate in the IVIg group was 2.6%, significantly lower than the
4.6% rate seen in controls.Neurology 2009;73:180-185.
Alzheimer's Disease
information - symptoms
There are several symptoms common to Alzheimer disease patients. These
symptoms include: trouble remembering things...at first, only short-term memory
may be affected. The individual may forget an appointment or the name of a new
acquaintance. A person may also forget where they left things. Eventually,
long-term memory is also impaired. An inability to correctly identify familiar
odors may be an early indication of the onset of Alzheimer's disease.
Alzheimer disease symptoms include mood or personality changes. A person may
suddenly become angry or sad for no apparent reason. Or someone who was social
and outgoing may become withdrawn.
Trouble completing ordinary tasks is another symptom of
Alzheimer's disease. Simple tasks that once caused no difficulty may become much
more challenging. For example, the individual may forget how to dress, use the
oven, etc.
Alzheimer disease symptoms include difficulty expressing thoughts and disorientation. We
all know what it's like to be driving and momentarily forget where you are
going. But those with Alzheimer's disease may get lost in their neighborhood.
They may also lose track of dates and the time.
Unusual behavior. The individual may wander, become
agitated, hide things, wear too few or too many clothes, become overly
suspicious, or engage in unsafe behaviors.
Alzheimer's Dementia characteristic
Alzheimer's dementia is
characterized by widespread neuronal loss, beta-amyloid deposits in the cerebral blood
vessels, development of neuritic plaques and the presence of neurofibrillary tangles.
These changes, occurring in the association area of the cerebral cortex, the hippocampus
and the middle and temporal lobes, are accompanied by decreased concentrations of the
neurotransmitter acetylcholine. Recent US census figures
suggest that by 2050, the number of people with AD will triple.
Pharmaceutical options for
Alzheimer's dementia
Cholinesterase inhibitors such as donepezil, rivastigmine,
and galantamine are
often used but they do not provide a cure or long term solution.
Celecoxib or naproxen medication use does not prevent the onset of
Alzheimer dementia, at least within the early years after initiation of
treatment. Celecoxib 200 mg bid does not slow the progression of Alzehimer's
dementia, and the occurrence of adverse events is expected for an elderly
population with a complex chronic medical condition.
Medicines most commonly prescribed for agitation and delusions in Alzheimer’s disease are not effective and put the patients at risk of serious adverse effects, including confusion, sleepiness and Parkinson’s disease-like symptoms. The drugs tested in the study, Zyprexa from Eli Lilly; Seroquel from AstraZeneca; and Risperdal from Janssen Pharmaceutical, belong to a class of medications known as atypical antipsychotics. These drugs are used to treat schizophrenia and other psychoses, and are commonly prescribed for elderly patients in long-term care facilities. About a third of the estimated 2.5 million Medicare beneficiaries in nursing homes in the United States have taken the medications.
Spinal fluid proteins for diagnosis
The levels of various proteins in spinal fluid, which can be sampled with a
spinal tap, can help identify people with early Alzheimer's disease who are
likely to experience a rapid worsening of their mental capacity. Patients with
low levels of amyloid-beta-42 or high levels of tau or ptau181, proteins
associated with Alzheimer's disease, are at increased risk for a rapid decline
in their thinking ability. Dr. Barbara J. Snider and colleagues from Washington
University School of Medicine studied 48 subjects with early Alzheimer's disease
who had only minor thinking problems at the time of spinal tap. The subjects had
at least 1 follow-up visit and the average follow-up period was 3.5 years.
Before amyloid-beta-42, tau, or ptau-181 can be used in clinical practice, Dr.
Barbara J. Snider notes, practical guidelines will need to be created regarding
the interpretation of individual results. Archives of Neurology, May 2009.
Alzheimer's Dementia questions
Q. My wife has Alzhiemer's dementia, as well as a heart condition. She takes warfarin,
plavix. otherwise in good health. I thought I saw a page titled natural
prescription for Alzheimer's listing recommended vitamins. Could you send this
page?
A. See
Alzheimer's dementia information web page.
Q. What herbal and nutritional formula would you recommend for Alzheimer's.
A. We can't make specific suggestions, we can only provide general
info for your doctor to review with you. Some people appreciate
Mind-Power-Rx formula.
Q. I have a long family history of Alzheimer's disease.
I have been looking at different products that say they can help with Alzheimer.
What I want to know how to judge or look for the best natural product that is
being sold for Alzheimer's disease. I just ran across your site. Besides having
memory problems, I have had breast cancer (now 2 years ago) and thyroid surgery
and I drag every day to work, work at home.
A. We are not aware of long term research with any natural
supplement that has proven to be effective in terms of prevention of Alzheimer's
disease but there are some that have potential and they are listed on this page.
Q. Is
tongkat ali helpful as an herb for Alzheimer's dementia?
A. We doubt if this herb would be helpful.
Do you have any information regarding using nattokinase
for Alzheimer's, ie. dissolving plaque in the brain that causes the disease.
We have not seen any research with nattokinase enzyme for
this condition.
We will update this page with additional information as more Alzheimer's research studies are published.