Anagrelide side effects

Anagrelide is a pharmaceutical drug for thrombocythemia. Anagrelide is used to decrease the number of platelets (a type of blood cell that is needed to control bleeding) in the blood of patients who have a myeloproliferative disorder (condition in which the body makes too many of one or more types of blood cells) such as essential thrombocythemia (condition in which the body makes too many platelets) or polycythemia vera (condition in which the body makes too many red blood cells and sometimes too many platelets). Anagrelide is in a class of medications called platelet-reducing agents. It works by slowing the production of platelets in the body.

Benefit of anagrelide
Hydroxyurea plus low-dose aspirin is superior to anagrelide plus low-dose aspirin for patients with essential thrombocythemia at high risk for vascular events.

Anagrelide side effects
Leg ulcers associated with intake of anagrelide.
Dtsch Med Wochenschr. 2007 Feb 16;132(7):319-21. Dermatologische Klinik und Poliklinik, Universitatsklinikum Essen.
Extremely painful leg ulcers on the lateral aspect of both ankles developed in a 38-year-old man for the first time six weeks after starting treatment with anagrelide for thrombocythemia. Extensive diagnostic tests, including laboratory tests, Doppler and duplex ultrasound of the superficial and deep leg veins, histopathology and bacteriological and mycological tests excluded vascular disease, vasculitis and metabolic causes. Despite adequate local treatment the ulcerations did not improve until anagrelide was discontinued and replaced by hydroxyurea. Anagrelide administration was the most likely cause of the leg ulcerations, even though this possible side effect has only been described once in the literature.

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