Andrographis is a shrub found throughout India and other Asian countries. Andrographis has become popular in Scandinavia as a treatment for colds. For more Andrographis information.

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Andrographis paniculata is an herb commonly used in China, India and other countries in subtropical and Southeast Asia. Both the fresh and dried andrographis leaves, as well as the fresh juice of the whole plant, have been used in a variety of cultures. In traditional Chinese herbalism, Andrographis is used to support healthy digestive, cardiovascular and urinary systems. In Sweden, Andrographis has been used for more than 10 years as a primary herb for the winter season for immune support.

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Andrographis paniculata Supplement Facts
Andrographis Standardized 300 mg*
   Extract (10% andrographolides)
Andrographis Herb 100 mg*
   (Andrographis paniculata)

* Andrographis paniculata daily value not established.

What's in Andrographis paniculata?
Some of the compounds in andrographis are diterpene lactones known as andrographolides. Andrographis contains andrographolide, deoxyandrographolide and neoandrographolide. This herb is also known as Kalmegh.

Potential uses of Andrographis
There has been a great deal of research done with andrographis. Here's a summary of some of the benefits:

Anti-inflammatory
Andrographis contains many flavonoids, which have anti-inflammatory properties. Andrographolide, an active component of andrographis paniculata, inhibits inflammatory responses by rat neutrophils.

Anti-tumor
Andrographis paniculata has anti-carcinogenicity properties.

Anti-oxidant and liver protection
Andrographis paniculata treatment prevents BHC induced increase in the activities of enzymes y-Glutamyl transpeptidase, glutathione-S-transferase and lipid peroxidation. The activities of antioxidant enzymes like superoxide dismutase, catalase, glutathione peroxidase and the levels of glutathione were decreased following BHC effect. Administration of androgrpahis showed protective effects in the activity of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase as well the level of glutathione. The activity of lipid peroxidase was also decreased. The result indicate antioxidant and hepatoprotective action of andrographis.

Autoimmune disorders
I'm writing to ask a few questions about andrographis paniculata that no supplemental company is willing to answer. I have been researching the possible effects of this herb and I continue to find research supporting it's immune system boosting qualities. My questions are: Could this herb ignite an (known or unknown) autoimmune disorder? Could it temporarily mimic symptoms of an autoimmune disorder ie, vision loss (MS), arthritis, etc?
   A. We have not seen any studies that suggest this herb initiates or causes worsening of autoimmune disorders.

Andrographolide interferes with T cell activation and reduces experimental autoimmune encephalomyelitis in the mouse.
J Pharmacol Exp Ther. 2005 Jan; Iruretagoyena MI, Tobar JA, González PA, Sepúlveda SE, Figueroa CA, Burgos RA, Hancke JL, Kalergis AM. Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Alameda 340, Santiago, Chile.
Andrographolide is a bicyclic diterpenoid lactone derived from extracts of Andrographis paniculata, a plant indigenous to South Asian countries that shows anti-inflammatory properties. The molecular and cellular bases for this immune influencing capacity remain unknown. Here, we show that andrographolide is able to down-modulate both humoral and cellular adaptive immune responses. In vitro, this molecule was able to interfere with T cell proliferation and cytokine release in response to allogenic stimulation. These results were consistent with the observation that T cell activation by dendritic cells (DCs) was completely abolished by exposing DCs to andrographolide during antigen pulse. This molecule was able to interfere with maturation of DCs and with their ability to present antigens to T cells. Furthermore, in vivo immune responses such as antibody response to a thymus-dependent antigen and delayed-type hypersensitivity were drastically diminished in mice by andrographolide treatment. Finally, the ability of andrographolide to inhibit T cell activation was applied to interfere with the onset of experimental autoimmune encephalomyelitis (EAE), an inflammatory demyelinating disease of the central nervous system that is primarily mediated by CD4(+) T cells and serves as an animal model for human multiple sclerosis. Treatment with andrographolide was able to significantly reduce EAE symptoms in mice by inhibiting T cell and antibody responses directed to myelin antigens. Our data suggest that andrographolide is able to efficiently block T cell activation in vitro, as well as in vivo, a feature that could be useful for interfering with detrimental T cell responses.

Andrographis for colds and flu
Long known in traditional Asian medicine as an immune system booster, Andrographis has demonstrated significant activity in fighting common cold, flu, and upper respiratory infections. Two randomized double-blind, placebo-controlled parallel group clinical trials were performed to investigate the effect of a standardized extract (SHA-10) of Andrographis paniculata fixed combination (Kan jang) in the treatment of uncomplicated upper-respiratory tract infections. In both studies throat symptoms/signs, were found to show the most significant improvement.

Andrographis paniculata in chemotherapy
Ameliorating effects of Andrographis paniculata extract against cyclophosphamide-induced toxicity in mice.
Asian Pac J Cancer Prev. 2006 Oct-Dec;7(4):609-14. Department of Immunology, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India.
Major drawbacks of chemotherapeutic agents are their toxic side effects and lack of tumor specificity. Immunological and biochemical studies were here carried out to investigate protective effects of ethanolic extract of Andrographis paniculata against cyclophosphamide induced toxicity in vivo. Intraperitoneal administration of the extract significantly increased the total WBC account, bone marrow cellularity cells / femur) in cyclophosphamide treated animals, when compared to cyclophosphamide alone treated control mice. Weights of lymphoid organs such as a spleen and thymus, reduced by cyclophosphamide administration, were also increased by andrographis paniculata treatment. Reduction of GSH in liver and in intestinal mucosa of cyclophosphamide -treated controls was significantly reversed by andrographis paniculata administration, with amelioration of changes in serum and liver ALP, GPT, LPO (lipid peroxidation). Histopathological analysis of small intestine also suggests that extract could reduce the CTX induced intestinal damage. The level of proinflammatory cytokine TNF-alpha, which was elevated during cyclophosphamide administration, was significantly reduced by the andrographis paniculata extract administration. The lowered levels of other cytokines like IFN-gamma, IL-2, GM-CSF, after cyclophosphamide treatment were also found to be increased by extract administration.

Diabetes
The ethanolic extract of Andrographis  possesses antidiabetic property. Its antidiabetic effect may be attributed at least in part to increased glucose metabolism.

Familial Mediterranean Fever
Androgrphis paniculata, in combination with other herbs, may be helpful (see the study below).

Andrographis and HIV
Andrographolide may inhibit HIV-induced cell cycle dysregulation, leading to a rise in CD4(+) lymphocyte levels in HIV-1 infected individuals.

Immune system
Most flavonoids have anti-microbial activity and have a positive effect on the immune system.

Mind
Andrographis extract exhibited a significant alteration in behavior pattern and a reduction in spontaneous motility in animals. The extract also produced a prolongation of the pentobarbitone-induced sleeping time and lowered the body temperature in different experimental animal models.

Andrographis Supplier
LiuZhou Greensky Natural Ingredients Co., Ltd was established in 1997. Located in LiuZhou New Technology Developing Zone. Which is focused on researching natural herb medicines, available single, refining the available ingredient, breeding herbal remedies, and studying on new medicines. most of our product were exported to Europeam, North America and South-east Asia. main product andrographis paniculata extract (andrographolide) and silkworm chrysalis oil. Specification : Andrographolide 1%, 10%, 50% 90% , 98% Analysis Specification Assay (By HPLC) Andrographolide 98% Physical & Chemical Control Identification Positive Reaction Appearance Crystalline Powder Color White Odor None Taste Bitterness Please contact us if you are interested in our products.

Andrographis product questions
Q. Does andrographis help with weight loss?
   A. We have not come across any research regarding andrographis to lose weight. Hoodia and green tea extract may be helpful.

Q. Is AHCC helpful for the immune system like andrographis herb?
   A. They are very different in how they work.

Does the herb tongkat ali influence the immune system and can it be taken along with andrographis herb?
    This aphrodisiac herb probably does influence the immune system, but we don't know how it interacts with andrographis.

Do you know if andrographis paniculata can be used in conjunction with Cymbalta, Trazadone, Abilify, and Concerta? Our doctor says my daughter should not use Sudafed with these drugs because they have too many overlapping compounds, and might be harmful to her. I'm trying to find out whether this particular herb can help with uncomplicated respiratory issues safely.
    We have not seen any studies with the combination of this herb and Cymbalta, Trazadone, Abilify, and Concerta. One option, if her doctor approves, is to use a small amount of the herb for a week before trying higher amounts.

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