Boswellia side effects and medical uses for arthritis and medical diseases that involve inflammation
Boswellic acids benefit a number of conditions including asthma and osteoarthritis

March 24 2014

Boswellia is an Ayurvedic herb that contains anti-inflammatory triterpenoids called boswellic acids. Boswellic acid and its derivatives have anti-carcinogenic, anti-tumor, and blood cholesterol and trigylceride activities. Dried extracts of the resin have been used since antiquity in India to treat inflammatory conditions. This herb is often added to formulas for joint health.

Boswellia side effects and safety
No major boswellia side effects are reported in the medical literature. However, in rodent studies Very high doses have caused some harm to the liver whereas low dosages were protective to the liver.

I take boswelia and mangosteen everyday for my back pain. I have in the last couple of months become very tired and can't seem to wake up during the day.
    Sometimes taking too much of certain supplements for too long can cause fatigue or other unexpected side effects. Fatigue can also be caused by a number of other factors that need to be evaluated by a health care provider.

I'm looking for contraindications. Is it safe for anyone? Does it thin your blood?
  
No major adverse reactions have thus far been reported in the medical literature. We don't know how much, if any, influence it has on clotting.


Buy Boswellia Extract , 65% Boswellic Acids, Nature's Way

This herb is standardized to 65% boswellic acids, the researched clinical dose used to support joint health and mobility. It is concentrated from specially processed resins and gums. The benefits are due to the presence of four triterpene acids, especially beta boswellic acid. This high quality product is carefully standardized to contain at least 65% boswellic acids.




 

Buy Boswellia extract, Joint Power Rx with chondroitin and glucosamine
Supplement Facts:
Boswellia serratta dried extract - 307 mg   
    Yielding 65% extract, yielding: 200 mg Boswellic Acids

Suggested Use:  One tablet boswellia extract one or two times daily with a meal. There is not enough research yet to determine the full benefits this plant offers and to know with more certainty the best boswellic acid dosage to take for long term use.

For more info on Joint Power Rx. For more info on glucosamine sulfate and another helpful nutrient chondroitin sulfate along with MSM promoted as a supplement for arthritis.

Mechanism of action
it may inhibit proinflammatory 5-lipoxygenase products and blockage of leukotriene synthesis.

Boswellic acid research
Boswellia plant species are used in traditional medicine in India and African countries for the treatment of a variety of diseases. Animal experiments show anti-inflammatory activity of the boswellia extract. The mechanism of this action is due to boswellic acids. They are different from that of NSAID. Boswellic acids, the main active ingredients of Boswellia serrata, are anti-inflammatory agents, inhibiting 5-lipoxygenase, the key enzyme of leukotriene biosynthesis. The most evident action of boswellic acid is the inhibition of 5-lipoxygenase. However, other factors such as cytokines (interleukins and TNF-alpha) and the complement system are also candidates. Moreover, leukocyte elastase and oxygen radicals are targets.

What is the difference between bowellin and boswellic acids?
   Boswellia is the name of the herb, and the herb contains many different active chemicals. Some of their names are boswellin and boswellic acid.

Potential Benefits

Asthma
In a double-blind, placebo-controlled trial, the use of 300 mg 3 times daily led to improvement in signs and symptoms of asthma, including a reduction in asthma attacks.

Inflammatory Bowel Disease
In one study of 30 patients aged 18-48 with chronic colitis, 20 were given boswellia extract 300 mg 3 times a week for 6 weeks, and the other 10 were given sulfasalazine, 1 g three times a day. Of the 20 treated, 14 went into remission, as did 4 of the 10 treated with the drug. Patients were studied at the Department of Medicine, Medical College Jammu, J&K, India suffered from chronic colitis characterized by vague lower abdominal pain, bleeding per rectum with diarrhoea and palpable tender descending and sigmoid colon. The inflammatory process in colitis is associated with increased formation of leukotrienes causing chemotaxis, chemokinesis, synthesis of superoxide radicals and release of lysosomal enzymes by phagocytes. The key enzyme for leukotriene biosynthesis is 5-lipoxygenase. boswellic acids were found to be non-redox, non-competitive specific inhibitors of the enzyme 5-lipoxygenase.

Liver protection
Effect of hexane extract of Boswellia serrata oleo-gum resin on chemically induced liver damage.
Pak J Pharm Sci. 2006.
The hexane extract of oleo-gum-resin was evaluated for its effect on liver injury induced by carbon tetrachloride, paracetamol or thioacetamide. Boswellia serrata was given in two different doses. Silymarin, a known hepatoprotective agent was used as standard. The lower dose reduced the elevated levels of serum marker enzymes and prevented the increase in liver weight in all three models of liver injury, while the higher dose showed mild liver protective activity. The hepatoprotective effect of lower dose was supported by changes in histopathology.

Osteoarthritis
An Ayurvedic herbal combination of ashwagandha, boswellia , and curcumin was evaluated in a randomized, double-blind, placebo controlled, cross-over study in patients with osteoarthritis. Treatment with this formulation produced a significant drop in severity of pain.

Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial.
Kimmatkar N. Phytomedicine. 2003. MS Orthopedics, Indira Gandhi Medical College, Nagpur, India.

Sexual improvement
Can one combine aphrodisiac tongkat ali herb with boswellia or will there be side effects?
    Boswellia does not have too many side effects by itself, but the herbal aphrodisiac does.

Dosage
No guidelines have been established as to the ideal dosage. One option is to take boswellia 300 to 500 mg 2 or 3 times a day of an extract standardized to contain 30 to 40% boswellic acids. The full effect may take several weeks.

Products
It is sold in a number of concentrations and extract potencies including 65 percent boswellic acids.

Source Naturals - Boswellia extract, 100 Tablets
Boswellia complex by National Health Consultants

I came across a product called Boswellia Complex. The website says that the ingredients have pain relieving, anti-inflammatory properties. Is this true?
   Boswellia Complex is a combination of herbs. Each capsule contains: Bromelain (2400 gdu/gram) 100 mg, Boswellia serrata extract (65% organic acids) (Alpha and beta Boswellic acids min. 30% 200 mg, Curcuma longa (tumeric) extract (total cucuminoids 80-80% 200 mg and Quercetin 100 mg. Although we have not seen specific research with this product, the ingredients in itappear to be beneficial.

Is your extract H15? I'm looking for H15 extract that may help in GBM (cancer tumor in brain).
    There are various extracts of this herb and a variety of them have been studied with good results. H15 is one brand that has been used in certain studies and it is not clear exactly what percentage of bacosides it has, but other extracts have shown positive results in studies, also.

Various species
I would like to mention about medical properties of resin of some species. Boswellia Carteri (Somali Frankincense) resin: First Grade Resin of this tree is powerful anxiolytic. Even more powerful than L-Theanine, Kava Kava and Kanna (Sceletium Tortuosum), L-Theanine and Valerian Root when used as chewing gum for 1 hour about 4-5 grams. It overcomes deep fears, chronic fears, anxiety, frightened mood, frights, palpitations due to anxiety when drink coffee and Post Traumatic Stress Disorder type of fears. Medical effect continue approximately 6 hours after chewing. Boswellia Sacra (Omani Frankincense) resin: First Grade resin of this tree overcomes irritability, chronic irritability, furiousness, anger, nervousness, when used as chewing gum approximately 4-5 grams at a time for 1 hour. Medical effects continue aproximately 5-7 hours after chewing. Boswellia Papyrifera resin is powerful memory enhancer for dementia, memory loss, memory impairment. There is not any company that produce extract or capsules of these resins over the world now. Please make extract and capsules of these resins for people. However research medical properties of other species such as Frereana, Thurifera, Bullata, Delzei, Dioscoridis. There are so powerful medical properties of such species.
   Thanks for writing to us, we will look for research trials to confirm your viepoints.

Suppliers and manufacturers, press release received in 2010
Sabinsa introduces Boswellin PS, a natural extract from the gum resin of boswellia serrata (Indian frankincense), with enhanced water solubility and joint health support potential. Sabinsa debuted Boswellin PS at Supply Expo 2010. In addition to boswellic acids, the PS version contains Polysal, a natural polysaccharide from the gum resin. Moreover, the PS version with a two stage active constituents release profile provides longer lasting benefits than conventional extracts that are based on boswellic acids alone. Both boswellic acids (more specifically Acetyl-11-keto-beta-boswellic acid, AKBBA, the most effective of the boswellic acids, present in enriched concentrations in Boswellin P and Polysal are effective in reducing the markers of inflammation, with benefits in managing the symptoms of discomfort associated with conditions such as arthritis. Two stage action refers to the initial healthful effects of the water soluble Polysal, that are later sustained by the more slowly absorbed lipophilic boswellic acids, AKBBA in particular. Boswellin PS contains no added excipients or fillers, and offers safe and sustained natural support in managing discomfort associated with inflammation. Boswellia has a long history of medicinal use in the Ayurvedic tradition in managing inflammatory conditions. The extract has been used in joint health support products, as a dietary supplement in the US for over 15 years. Boswellin PS represents an improvement over existing conventional extracts, providing manufacturers with a more soluble version of this healthful natural extract that offers an unique active ingredients release profile.

HerbaKraft Offers Pharma Grade Boswellia serrata Extract 70%· Anti-inflammatory· Supports Joint Health. Full Documentation Available· Free Samples Contact us for pricing, technical data sheets, and samples. Lissett Jaquez HerbaKraft 3501 Hoes Lane, Suite 102 Piscataway, NJ 08854.