Carnosine side effects information study review and health benefits?

March 25 2014

Carnosine is a small molecule composed of the amino acids histidine and alanine. It is found in relatively high concentrations in several body tissues—most notably in skeletal muscle, heart muscle, nerve tissue and brain. The exact biological role is not well understood, but many studies indicate that carnosine has antioxidant potential. It may also act as a neurotransmitter (chemical messenger in the nervous system).
   Carnosine has been called a longevity nutrient since laboratory studies on tissues indicate that it can delay senescence and provoke cellular rejuvenation in cultured human fibroblasts. However, until human studies are done, we will not know if chronic supplementation leads to lifespan enhancement.

Carnosine side effects, risk
I have read carnosine has no reported side effects how ever I did find an article where the author stated that high doses during long period of time might lead to a serious condition where the body can't produce sufficient amounts of an enzyme that normally brakes it down leading to overload which according the author would have serious effects.
   As long as the dose is taken every other day and a week off each month, it should not have any long term side effects. Human trials for many months or years are not available to tell us if the author you mention above is correct claiming that carnosine use prevents the activity of an enzyme.

purchase L Carnosine 500 mg pill as antioxidant
L-Carnosine supports healthy aging and cellular rejuvenation by its effects on two mechanisms: Glycosylation and Free Radical Damage. Glycosylation is the oxidation of proteins by glucose resulting in cross-linking of proteins and which is implicated in loss of cell function, genome integrity and accelerated aging. This nutrient protects the aging process of the brain by retarding lipid peroxidation and stabilizing cell membranes.

purchase Carnosine, Mind Power Rx, Eyesight Rx

purchase Carnosine 500 mg each pill

Usage: Take half or 1 carnosine capsule before or with breakfast a few times a week, or as directed by your qualified health consultant.
Many people notice clarity of vision and a mood lift.

 

Dosage, how to avoid side effects
I am looking for carnosine at 100 mg or 200 mg per pill. Do you supply different strengths?
   We only carry 500 mg but it is easy to open a capsule by pulling on each side, pouring our a portion in a glass of water or juice, and closing the capsule to use the rest another day.

Given that Dr. Marios Kyriazis says there is no apparent benefit in taking more than 100 to 200 mg of carnosine per day, has any thought been given to making capsules in a lower dosage than 500mg, even though one could open them and taken a lesser amount?
   There is a wide range of dosages that work for people, and people have the option to take a portion of a capsule. and some buyers want large amounts in a capsule, it is difficult to please everyone.

Absorption and metabolism
Is there any reason to believe that carnosine, when taken internally, actually increases the amount in the body (eg-the muscles) ? My understanding is that it is a di-peptide made up of two amino acids, histidine and alanine, and when taken internally, it's broken down into those amino acids, which can be reassembled to form back in the body. But will this result in more carnosine actually being produced than if the body just relied on the amounts of histidine and alanine normally found in the blood?
   We have not seen any detailed analysis of this in the human body after ingestion, but it does appear that carnosine can be absorbed intact. For instance, another amino acid combination creatine, is absorbed and goes to muscle tissue to help muscles grow.

I have been researching the use of carnosine as an anti-aging supplement, and found a couple references that mention that it should be taken in an enteric-coated tablet because stomach acid will break it down into its component parts (alanine and histidine) and reduce its beneficial effects. One site even said all vitamins should be taken enterically coated.
   We have not seen such research to confirm these claims.

ADHD in a child
I read that a doctor recommends a child to take a lower dose of carnosine for ADHD than adults, that it should be between 100 to 200mg before breakfast and at lunch time. But, how do i do that? I pour a little powder from the capsule in his drink in the morning and then another little in the afternoon for lunch or how can i split that 500mg capsule into those doses?
   Dosages of carnosine for ADHD are just rough estimates, there is no way to tell what dosage or what supplement a child will respond to, if any. One option is to start with a fifth or so of a 500 mg capsule in the morning and on subsequent days the dosage can be increased or decreased depending on response and your doctor's advice. There is no agreed upon treatment for ADHD with supplements, it is a matter of trial and error. The capsule of the carnosine can be opened by pulling on each side.

Anti aging
Use of carnosine as a natural anti-senescence drug for human beings.
Biochemistry 2000.

Autism benefit
From the day she was born, Researchers at the Autism and Epilepsy Specialty Services in Lake Bluff, Illinois, investigated 31 children with autism in an 8-week, double-blinded study to determine if carnosine would result in changes. This is a natural substance composed of 2 amino acids. It is found in relatively high concentrations in several body tissues, muscles, and nerve tissue, including the brain. The children received 800 mg of carnosine a day and were compared with a group of children on placebo. After 8 weeks, children showed statistically significant improvements on several tests including an improvement in vocabulary and recognizing a picture.
   L-carnosine is sold in health food stores most commonly in capsules of 500 mg. It would be worthwhile to try 100 to 200 mg of this nutrient before breakfast and lunch for a few weeks under a pediatricianís supervision. The dose would be much less than in adults. It also comes in a liquid form.

Cataract
We have been obtaining Joint Power Rx and Lyprinol from Physician Formulas for some time now and through web searches I have found that carnosine taken together with the eye drops N-acetylcarnosine may be a good treatment for cataracts. Is there any reason you do not mention this type for eye drop?
   We are still trying to determine the legality of carnosine eye drops and to see whether these are called dietary supplements or drugs, our legal staff is looking at it.

Eye health
Have you heard of a product called Bright Eyes with carnosine made in the UK. Bright Eyes claims to dissolve cataracts in a few months. 
   To the best of our knowledge, any product that is an eye drop cannot be considered a dietary supplement according to the FDA and would not be allowed for sale without a prescription or FDA approval. if any company would just put out eye drops without strict control, one can imagine eye infections and other problems if the production is not sterile.

I read about the benefits of n-acetyl-l carnosine that has been put into eye drops, Ortho Eyes. I was just wondering if you have any articles on Ortho Eyes.
   Sorry we have not studied Ortho Eyes eye drops treatment in any detail to have a reliable opinion.

GI system, stomach ulcer protection
Zinc carnosine is an artificially produced carnosine derivative that is linked to zinc in a one-to-one ratio. Dr. R. J. Playford of Queen Mary's School of Medicine & Dentistry in London conducted a series of studies to determine whether it would help protect against the gut-eroding effects of the non-steroidal anti-inflammatory drug (NSAID) indomethacin. In petri dishes, the researchers found that it induced cells to travel to a simulated wound area and also triggered increased cell proliferation, suggesting that it would improve wound healing. In rat studies, the supplement protected against damage to the stomach lining and small intestine caused by indomethacin. The researchers also tested it in 10 healthy men and women who took either zinc carnosine or placebo while taking indomethacin. While the NSAID tripled gut permeability in those on placebo, indomethacin had no effect on gut permeability in participants on zinc carnosine. As many as 70 percent of NSAID users may have damage to their gut lining due to blood and protein loss. While protein pump inhibitor drugs can help protect the stomach, they don't prevent injury to the small intestine, and while drugs called prostaglandin analogs may protect the small intestine, these drugs produce side effects like diarrhea. Gut, 2007.

Kidney disease
Q. I am a type 1 diabetic for nearly 30 years. In recent years, Iíve developed some kidney trouble which may lead to (God forbid) dialysis. Iíve been researching carnosine for its benefit to diabetics in protecting kidneys. However, Iíve come across conflicting information regarding the appropriate dosage. Some suggest as much as 1,000mg per day, so that it doesnít get destroyed by enzymes and actually achieves the therapeutic result for which it is taken.
   A. Not enough research is available to know how much this nutrient will help and in what dosages and how safe it is. But it would seem prudent if your doctor agrees to begin with a dosage of 250 mg or so and monitor the response after a few days or weeks while increasing the dosage.

Sexual health
I have been taking a carnosine supplement for a few weeks and want to try an herbal product for libido improvement such as tongkat ali. I can't find any mention anywhere if they can be taken together.
   Tongkat ali is quite potent and it is best to take it by itself unless you take a tiny amount of each..

Use with other supplements, interactions
I am taking 100 mg of carnosine, but recently found a product called 'Peak', developed by Dr. Eliezer Rapaport, for the muscles. I can't find any information to connect with Dr. Rapaport. I wonder if you can tell me if there would be any conflict in taking both. I found 'Peak' sold by Swanson Vitamins and and interview of him by Dr. Passwater.
    A search online reveals Peak to contain yohimbe, tribulus, and several other potent herbs. It is best to learn how each supplement works by itself for a few days before combining them. It is not possible to predict a reaction in any one individual since different people have different responses.

Brands over the counter, in health food stores, online
Jarrow Formulas, 500 mg each capsule.

Dyspraxia
I'm from Italy, I have a daughter of 14 years old with dyspraxia of speech, she doesn't never spoke, she has many problems in movements of mouth, tongue, and blocked jaw, she is visited of many physicians in Italy, but also in Canada and in USA, I contact Lori Denny Knowles and she said me that there are some supplements to support for example neurotransmitters, nervous system and also immune system, because she made analyses and there are problems with neurotransmitters, my object is to find something to help her to better her health condition. I would know if the integrators DMG, TMG, carnosine, are ok for her.
    It is not possible for us to predict her response to these supplements, but when trying new ones it is preferable to use them one at a time and in low dosages for a week before adjusting the dosage. We wish her well.

Suppliers
My name is Rosina Fan, sales of Shanghai Science Pharmaceutical Chemical Co., Ltd is a specialized manufacturer of amino acid derivatives, peptides, vitamin derivatives and other pharmaceutical and chemical intermediates. Most of our products are exported to worldwide, such as USA, Europe, Japan and India. We are proud of our good service and reputation in this industry. I have learned that you esteemed company supplies the finished product: L-Carnosine for so many years ,one of the ingredients are L-Carnosine, and taking this chance, I would like to introduce you our main product,L-Carnosine, can prevent diabetic side effects and diabetic complication. It can also act as a new approach to stopping and preventing diabetic retinopathy. Yours faithfully, Rosina Fan/ Sales Shanghai Science Pharmaceutical Chemical Co., Jiading, Shanghai, China