CDP-Choline
supplement pill benefit and mental enhancement 250 mg capsules
CDP-choline stands for cytidine 5-diphosphocholine, an intermediate in the
biosynthesis of membrane phospholipids and brain acetylcholine. CDP-choline is approved in
Europe and Japan for use in stroke, Parkinson’s disease and other neurological
disorders and is sold with the brand name
Citicoline. In a way, you could consider
CDP-choline as more potent form of choline. Studies show that CDP-choline helps make
phosphatidylcholine in human brain cell membranes in older individuals; may increase
acetylcholine synthesis; improves mental performance in patients with Alzheimer's disease;
and even improves memory in elderly patients with memory deficits. A Belgian study has
shown that CDP-choline administration to dogs improves their ability to learn and
remember.
CDP-Choline, 250 mg, 60 Capsules
Stabilized CDP-Choline (cytidine 5'diphosphocholine) is a
naturally occurring, water soluble biological compound that is an essential
intermediate for the synthesis of phosphatidylcholine, a major constituent of
the grey matter of brain tissue (30%). CDP choline is metabolized to yield the
free nucleotide cytidine and choline. Scientific research demonstrates that CDP
Choline consumption promotes brain metabolism by enhancing the synthesis of
acetylcholine, restoring phospholipid content in the brain and regulation of
neuronal membrane excitability.
If you wish to buy CDP-Choline supplement on sale. CDP choline is a much better mind booster than Phosphatidylcholine or a related substance called Phosphatidylserine-PS. Consider Mind Power Rx with bacopa monnieri and ginkgo biloba herbs.
CDP-choline Research
The administration of oral CDP-choline may be of use in reversing age-related
changes in the brain. CDP-choline helps to increase levels of
CDP-choline may be helpful in
Alzheimer's disease
Double-blind placebo-controlled study with citicoline (cdp-choline) in APOE genotyped
Alzheimer's disease patients. Effects on cognitive performance, brain
bioelectrical activity and cerebral perfusion.
Alvarez XA.
EuroEspes Biomedical Research Center, A Coruna, Barcelona, Spain.
Methods Find Exp Clin Pharmacol. 1999 Nov;21(9):633-44.
Cytidine 5'-diphosphocholine (cdp-choline) is a an endogenous intermediate in the
biosynthesis of structural membrane phospholipids and brain acetylcholine.
CDP-cholinehas been extensively used for the treatment of neurodegenerative
disorders associated with head trauma, stroke, brain aging, cerebrovascular
pathology and Alzheimer's disease. In this study we have investigated the
efficacy and safety of the treatment with cdp-choline versus placebo in patients
with Alzheimer disease. Thirty older patients with mild to moderate senile dementia (GDS: stages 3-6) of the Alzheimer
type were included in a double-blind, randomized and placebo-controlled clinical
trial. After a 2-week period of drug washout, patients were treated with i)
placebo or ii) 1,000 mg/day of citicoline for 12 weeks. As compared to placebo, cdp-choline improved cognitive performance in Alzheimer's disease patients with
APOE E4; and this improvement on cognition was more pronounced. CDP-choline also
increased cerebral blood flow velocities in comparison with placebo
when transcranial Doppler recordings from both hemispheres were considered
together, as well as diastolic velocity in the left middle cerebral artery. Patients treated with cdp-choline showed an increase in the percentage of
brain bioelectrical activity of alpha (occipital electrodes) and theta type
(left side electrodes), accompanied by a decrease in relative delta activity
particularly marked in the left temporal lobe. Significant differences with
respect to placebo were observed for theta activity in several fronto-parieto-temporal electrodes of the left hemisphere. Treatment with
cdp-choline tended to reduce serum IL-1 beta levels, mainly after 4 weeks of
administration, with no modified blood histamine content. In addition, neither
adverse side effects nor alterations in biological and hematological parameters
were induced by cdp-choline. The present data indicate that cdp-choline (1,000
mg/day) is well tolerated and improves cognitive performance, cerebral blood
perfusion and the brain bioelectrical activity pattern in AD patients. According
to our results, it seems that cdp-choline might be a useful treatment in
Alzheimer's disease, and that the efficacy of this compound is greater in
patients with mild mental deterioration and/or bearing the epsilon 4 allele of
the APOE.
A Mind Booster Helpful After Strokes
Findings recently presented at the American Stroke Association's 27th
International Stroke Conference indicate that CDP-choline may be
helpful in reducing damage after a stroke.
The most common cause of a
stroke
is blockage of a blood vessel within the
brain, which leaves a portion of the organ starved for blood and oxygen.
Bleeding within the brain can also lead to stroke. Much of the brain damage is
caused by a cascade of harmful chemicals released by dying cells.
Researchers at the National Institute of Neurological Disorders in Bethesda,
Maryland, reported data on two trials of the supplement citicoline, sold in some
health food stores or on the internet as CDP-choline. This nutrient is related
to choline.
One of the studies involved 41 patients who received 500 milligrams of
cdp-choline daily for 6 weeks after having a stroke. In the other, 62 stroke
patients took 2,000 mg of the drug every day for 6 weeks. The trials also
included 111 patients who received an inactive placebo. The researchers gauged
the supplement’s effectiveness by measuring the size of the infarct, or area of
dead tissue. They scanned patients' brains within 24 hours of the stroke and
again 12 weeks later. At the end of the study period, the investigators found
that infarct size measured by MRI scans had increased by 85% in patients on
placebo, by 34% in patients receiving the 500 mg dose of cdp-choline and by only
2% in patients receiving 2,000 mg cdp-choline.
Comments: CDP-choline is a more powerful form of choline, and most
users without a stroke notice an enhancement of mental focus, along with clarity
of vision and thinking with as little as 200 mg.
Safety of CDP-Choline and side effects
Toxicology studies show that CDP-choline is safe and produces no serious side
effects in doses ranging from 500 mg to 1,000 mg a day (Secades 1995). However,
most of the studies lasted less than a few weeks. Long-term safety is not known.
CDP-Choline Recommendations
CDP-choline has been used successfully in Europe for many years but
clinical experience in the US is limited. This nutrient appears to have a more
direct and immediate effect on the brain than its cousin choline. However, it is
difficult to predict at this time the long-term benefits or risks of regular
use. CDP-choline is a promising nutrient and I suspect that with time it will
become more popular. We are not aware of specific human studies
regarding the role of cdp-choline in
erectile
dysfunction as of September 2007.
CDP-Choline Experience
Within an hour of taking a 250 pill CDP-choline pill on an empty stomach, many
people notice being more alert and motivated. The effects last a few hours. In
addition, colors seem brighter and sharper and occasionally there can be a
slight libido enhancement. Because of the alertness it produces, I have
difficulty sleeping if I take this nutrient in late afternoon or early evening.
CDP choline pill questions
Q. Can CDP-choline pill be taken together with
Phenylalanine?
A. Too much stimulation may occur if both are taken in full
dosages.
Q. CDP Choline pill work great for prioritization, and transitioning from one task to another. Seems to have long term benefits even when I quit taking it for two weeks. I take Now Foods CoEnzyme B Complex with it (they work great together).
Q. I've learned that cdp-choline is neuroprotective
and great for many memory-related issues. However I'm wondering if it's
something that should be taken by a person with a glioma that was removed via
surgery and was treated radiation and chemotherapy temozolomide. It seemed like
it would be beneficial, but articles like the one below confuse me. "The
reduction in the tumour choline / water signal paralleled tumour volume change
and may reflect the therapeutic effect of temozolomide."
A. We are not aware of any research with cdp choline supplement and
its role on post glioma surgery. The sentence you mention medically speaking
does not seem to be relevant. There are countless biochemical events that occur
and isolating one factor does not give us a full picture.
I took a
tongkat ali pill in the morning followed by 2 cdp-choline pills in the
afternoon. Two hours after taking the brain booster I felt really hot and some
nausea.
Can CDP-choline supplement be taken the same day as acetylcarnitine?
Yes, if the dosage of each is cut in half.
What is the difference in action and potency between choline bitartarate supplement 500 mg and the Jarrow cdp-choline 250mg?
As to mental effects, the cdp choline is more potent, but
choline is used by the body for other purposes. It depends on your reason in
using these supplements. If it is for mental enhancement, cdp choline would be
more effective.
How much more powerful is CDP choline than regular
choline? If I wanted to take an amount equal to 900 mg of phosphatidylcholine,
would that just be just one 250 mg capsule of CDP choline? Would you say the
ratio is 1:4 for example?
It is very difficult to say since choline, cdp choline and
phophatidylcholine, even though they are similar, do follow different metabolic
pathways. There is some overlap but not fully. Therefore it is not easy or
practical to mention an accurate ratio since they have metabolic actions that
differ somewhat from each other, even though they have some similarities.
When CDP-choline is combined with yohimbe bark herb, there could be increased heart rate and sweating. We do not recommend this combination due to this untoward interaction.
My question is about a product I saw on the web that
contains 20mg of CDP Choline, 40mg of Dimethyl Glyciene, 65mg of Ashwagandha
powder, 1mg of Ginger root, 1mg of Piper Longum extract, 0.5 mg of Bioperine,
250 mcg of NADH,10% Mucuna Pruriens, 25% L-Dopa, 25% Panax Ginseng Extract, 2%
L-Arginine HCL, 2% L-Tyrosine, 2% Yohimbe Bark Extract, 10% Horny Goat Weed, 40%
Icarin, 40% Macca Powder, and 40% Tribulus Terrestris Extract. Can you tell me
if this is a safe combination of ingredients to take? I've heard yohimbe is
dangerous, especially when taken with Ginseng. But since its only 2% yohimbe
would this be safe to use? I was also thinking about taking the Fo Ti herb to
kind of neutralize or balance out the yohimbe.
We prefer not to comment on products we have
not developed. Safety of a supplement depends on dosage, and if using a product
for the first time it is a good idea to take a portion of a tablet or capsule.