CDP-Choline supplement pill benefit and mental enhancement 250 mg capsules

CDP-choline is short for cytidine 5-diphosphocholine, an intermediate in the biosynthesis of membrane phospholipids and brain acetylcholine. It is approved in Europe and Japan for use in stroke, Parkinson’s disease and other neurological disorders and is sold with the brand name Citicoline. In a way, you could consider it as more potent form of choline. Studies show that it helps make phosphatidylcholine in human brain cell membranes in older individuals; may increase acetylcholine synthesis; improves mental performance in patients with Alzheimer's disease; and even improves memory in elderly patients with memory deficits. A Belgian study has shown that administration to dogs improves their ability to learn and remember.

buy CDP-Choline, 250 mg, 60 Capsules

Stabilized CDP-Choline is a naturally occurring, water soluble biological compound that is an essential intermediate for the synthesis of phosphatidylcholine, a major constituent of the grey matter of brain tissue (30%). It is metabolized to yield the free nucleotide cytidine and choline. Scientific research demonstrates that consumption promotes brain metabolism by enhancing the synthesis of acetylcholine, restoring phospholipid content in the brain and regulation of neuronal membrane excitability.

If you wish to buy a CDP-Choline supplement on sale. This nutrient is a much better mind booster than phosphatidylcholine or a related substance called phosphatidylserine. Consider Mind Power Rx with bacopa monnieri and ginkgo biloba herbs.

Comparison
What is the difference in action and potency between choline bitartarate supplement 500 mg and the Jarrow cdp-choline 250mg? If I wanted to take an amount equal to 900 mg of phosphatidylcholine, would that just be just one 250 mg capsule of CDP choline? Would you say the ratio is 1:4 for example?
    As to mental effects, the cdp choline is more potent, but choline is used by the body for other purposes. It depends on your reason in using these supplements. If it is for mental enhancement, the former would be more effective. It is very difficult to say since, even though they are similar, do follow different metabolic pathways. There is some overlap but not fully. Therefore it is not easy or practical to mention an accurate ratio since they have metabolic actions that differ somewhat from each other, even though they have some similarities.

Research  and benefit
The administration of oral CDP-choline may be of use in reversing age-related changes in the brain. It helps to increase levels of phosphodiesters such as phosphatidylcholine and glycerophosphoethanolamine in the brain. These phosphodiesters form part of the cell membrane of brain cells and their levels are known to decline with age.

Alzheimer's disease
Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer's disease patients. Effects on cognitive performance, brain bioelectrical activity and cerebral perfusion.
Methods Find Exp Clin Pharmacol. 1999.
Cytidine 5'-diphosphocholine is a an endogenous intermediate in the biosynthesis of structural membrane phospholipids and brain acetylcholine, a neurotransmitter whose levels can be influenced by dietary supplements. CDP-choline has been extensively used for the treatment of neurodegenerative disorders associated with head trauma, stroke, brain aging, cerebrovascular pathology and Alzheimer's disease. Thirty older patients with mild to moderate senile dementia (GDS: stages 3-6) of the Alzheimer type were included in a double-blind, randomized and placebo-controlled clinical trial. Patients were treated with i) placebo or ii) 1,000 mg/day of citicoline for 12 weeks. As compared to placebo, cdp-choline improved cognitive performance in Alzheimer's disease patients with APOE E4; and this improvement on cognition was more pronounced. CDP-choline also increased cerebral blood flow velocities in comparison with placebo when transcranial Doppler recordings from both hemispheres were considered together, as well as diastolic velocity in the left middle cerebral artery.

Brain tumor, glioma
I've learned that cdp-choline is neuroprotective and great for many memory-related issues. However I'm wondering if it's something that should be taken by a person with a glioma that was removed via surgery and was treated radiation and chemotherapy temozolomide.
   We are not aware of any research regarding its role on post glioma surgery or any type of brain cancer treatment.

Erectile dysfunction, impotence
We are not aware of specific human studies regarding the role of cdp-choline in erectile dysfunction as of September 2010. Tongkat ali is a much more potent natural aphrodisiac.

Memory
Can CDP-choline supplement be taken the same day as acetylcarnitine?
    Yes, if the dosage of each is cut in half.

Stroke benefit
Findings recently presented at the American Stroke Association's 27th International Stroke Conference indicate that CDP-choline may be helpful in reducing damage after a stroke. The most common cause of a stroke is blockage of a blood vessel within the brain, which leaves a portion of the organ starved for blood and oxygen. Bleeding within the brain can also lead to stroke. Much of the brain damage is caused by a cascade of harmful chemicals released by dying cells. Researchers at the National Institute of Neurological Disorders in Bethesda, Maryland, reported data on two trials of the supplement citicoline, sold in some health food stores or on the internet. One of the studies involved 41 patients who received 500 milligrams of cdp-choline daily for 6 weeks after having a stroke. In the other, 62 stroke patients took 2,000 mg of the drug every day for 6 weeks. The trials also included 111 patients who received an inactive placebo. The researchers gauged the supplement’s effectiveness by measuring the size of the infarct, or area of dead tissue. They scanned patients' brains within 24 hours of the stroke and again 12 weeks later. At the end of the study period, the investigators found that infarct size measured by MRI scans had increased by 85% in patients on placebo, by 34% in patients receiving the 500 mg dose of cdp-choline and by only 2% in patients receiving 2,000 mg.

Safety of CDP-Choline and side effects
Toxicology studies show that it is safe and produces no serious side effects in doses ranging from 500 mg to 1,000 mg a day (Secades 1995). However, most of the studies lasted less than a few weeks. Long-term safety is not known.