Bulking agents
Bulking agents include
bran, Psyllium, calcium polycarbophil,
and methylcellulose. They provide fiber
and are the only laxatives acceptable for long-term use. They act slowly and gently and
are the safest agents for promoting elimination and preventing constipation. Proper use involves gradually increasing
the dose--best taken tid or qid with sufficient liquid (by adding 20 oz/day of
extra fluid) to prevent impaction --until a softer, bulkier stool
results. This approach produces natural effects and is not habit forming. Bulking agents
normalize both constipation and diarrhea. You may also consider
glucomannan.
Laxatives should be used carefully. Some may interfere with absorption of various drugs by binding them chemically (eg, tetracycline, Ca, phosphate) or physically (eg, digoxin on cellulose matrices). Rapid fecal transit may rush some drugs and nutrients beyond their optimal absorptive locus.
Osmotic agents are used to prepare patients for some diagnostic bowel procedures and occasionally to treat parasitic infestations. They contain poorly absorbed polyvalent ions (eg, Mg, phosphate, sulfate) or carbohydrates (eg, lactulose, sorbitol) that remain in the bowel, increasing intraluminal osmotic pressure and drawing water into the intestine. The increased volume stimulates peristalsis, which moves the water-softened stool easily through the bowel. These agents usually work within 3 h.
Secretory or stimulant cathartics (eg, cascara sagrada, senna and its derivatives, bisacodyl, phenolphthalein, castor oil) are often used to cleanse the bowel for diagnostic tests. They act by irritating the intestinal mucosa or by directly stimulating the submucosal and myenteric plexus. Some are absorbed, metabolized by the liver, and returned to the bowel in bile. Peristalsis and intraluminal fluid both increase, with cramping and passage of semisolid stool in 6 to 8 h. With continued use, melanosis coli, neuronal degeneration in the colon, "lazy bowel" syndrome, and serious fluid and electrolyte disturbances may occur.
Wetting agents
Wetting agents include detergent laxatives such as docusate which soften stools, making them easier to pass. They break down
surface barriers, allowing water to enter the fecal mass to soften and increase its bulk.
Increased bulk may stimulate peristalsis, which moves the softened stool more easily.
Mineral oil softens fecal matter, resulting in more easily passed stool mass, but it may
decrease absorption of fat-soluble vitamins. Wetting agents and mineral oil act slowly;
either may be useful after MI or anorectal surgery and when prolonged bed rest is
required.
Constipation help
Yoghurt containing galacto-oligosaccharides, prunes and linseed reduces the
severity of mild constipation in elderly subjects.
Eur J Clin Nutr. 2007 Feb 14; Sairanen U, Piirainen L, Nevala R,
Korpela R. 1Valio Ltd R&D, Helsinki, Finland.
Constipation is a common problem in the elderly. Dietary fibre is
recommended for its treatment. The aim was to examine whether yoghurt containing
galacto-oligosaccharides (GOS), prunes and linseed relieve constipation in
elderly subjects. A group of 43 elderly subjects with self-reported constipation
(mean age 76 years, range 61-92 years, 32 females, 11 males). The study
consisted of a 2-week baseline period and 2, 3-week dietary interventions, with
a 2-week wash-out period between the interventions. During the interventions,
the subjects ingested, in random order, 260 g/day of either control yoghurt or
test yoghurt containing GOS (12 g/day), prunes (12 g/day) and linseed (6 g/day).
The use of laxatives was controlled and only allowed after 2 days without
defecation. Daily intake of yoghurt containing GOS, prunes and linseed reduced
the severity of constipation in elderly subjects with mild constipation.
Relistor for Opioid-Induced
Constipation
FDA has approved Relistor (methylnaltrexone bromide) to help restore bowel
function in patients with late-stage, advanced illness who are receiving opioids
on a continuous basis to help alleviate their pain. Such patients include those
with a diagnosis of incurable cancer, end-stage chronic obstructive pulmonary
disease from emphysema, heart failure, Alzheimer’s disease with dementia,
HIV/AIDS or other advanced illnesses. Opioids can interfere with normal bowel
elimination function by relaxing the intestinal smooth muscles and preventing
them from functioning. Relistor acts by blocking opioid entrance into the cells
thus allowing the bowels to continue to function normally.
Constipation questions
Q. Does
Kava help with constipation?
A. We doubt it.
Q. Which supplements do you find helpful for
constipation?
A. Consider cascara sagrada, psyllium and glucomannan fiber.
Q. Does prune juice really work for constipation. How many
ounces are needed?
A. Yes, prune juice is an excellent choice to help with
constipation. Depending on the severity of the constipation, one to four ounces
is beneficial. You may consider drinking about two ounces late in the evening
and when you wake up in the morning drink a glass or two of cool water. This
will help you eliminate. Some people notice a slight mood elevation by having an
empty colon.
Q. Female, 65 years, melanosis coli and celiac disease -
my colon looks black! What do you suggest for this situation caused by nearly
forty years of constipation not being treated properly? Would any type of fiber
be helpful along with a laxative? Maybe acacia, salvia or glucomannan? Lactalose
and Miralax have been suggested as a laxative?
A. Specific suggestions have to be done by your doctor, but prune
juice and drinking 2 glasses of water first thing in the morning are safe
options for constipation.
Does the herb tongkat ali
cause constipation?
No, it does not.