Curcumin and Turmeric medical doctor formulated


Curcumin is one of the major antioxidants found in the spice
turmeric. The roots of the turmeric plant are used as an herb in Asian cooking such as curries. Curcumin
is a major component of Turmeric (Curcuma longa) and extensive
scientific research on curcumin and turmeric has demonstrated their potent antioxidant
properties. Through their antioxidant mechanisms, curcumin and turmeric support
colon health, exert neuroprotective activity and help maintain a healthy
cardiovascular system.
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Curcumin mechanism of action
The mechanism of action of curcumin is still being investigated, but curcumin
appears to have antioxidant and anti-inflammatory actions.
Benefit of curcumin
Alzheimer's Disease
Curcumin has compounds
that may be helpful in Alzheimer's disease. Curcumin
helps prevent the formation of
beta-amyloids which are neural fibrils in the brain that cause Alzheimer's.
Cancer
Curcumin may help fight cancer, including prostate cancer. Researchers have found in the lab that curcumin can
enhance the cancer-fighting power of treatment with TRAIL, a naturally occurring molecule
that helps kill cancer cells. TRAIL stands for tumor necrosis factor-related
apoptosis-inducing ligand. In an experiment with human prostate cancer cells in a
laboratory dish, the combination treatment killed off two to three times more cells than
either treatment alone.
Curcumin exerts multiple different suppressive
effects on human breast carcinoma cells in vitro.
In a test tube study, curcumin was found to
have anticancer effects on human Burkitt's lymphoma.
Curcumin and breast cancer
Curcumin appears to stop the spread of breast cancer tumor cells
to the lungs of mice. Tests have already started in people, too, says Bharat Aggarwal of the Department of Experimental Therapeutics at the
University of Texas M.D. Anderson Cancer Center in Houston, who led the
study. "What's exciting about this agent is that it seems to have both
chemopreventive and therapeutic properties. Earlier research showed that curcumin, an antioxidant, can help prevent
tumors from forming in the laboratory. For their study, Aggarwal and
colleagues injected mice with human breast cancer cells -- a batch of
cells grown from a patient whose cancer had spread to the lungs. The
resulting tumors were allowed to grow, and then surgically removed, to
simulate a mastectomy. Then the mice either got no
additional treatment; curcumin alone; the cancer drug paclitaxel (sold under the brand name Taxol); or curcumin plus Taxol.
Only half the mice in
the curcumin-only group and 22 percent of those in the curcumin plus
Taxol group had evidence of breast cancer that had spread to the lungs.
But 75 percent of animals that got Taxol alone and 95 percent of those
that got no treatment developed lung tumors. IN other words, the addition
of curcumin lowered the rate of cancer spread. Earlier studies suggest that
people who eat diets rich in turmeric have lower rates of breast cancer,
prostate cancer, lung cancer and colon cancer.
Heart
In a rodent study, curcumin was
found to protect rat myocardium against ischemic insult and the protective
effect could be attributed to its antioxidant properties.
Multiple Sclerosis
Curcumin may block
the progression of multiple sclerosis.
Uveitis
Efficacy of curcumin in the
management of chronic anterior uveitis.
Phytother Res. 1999 Jun;13(4):318-22. Department of Ophthalmology, K.G.
Medical College, Lucknow, India.
Curcumin was administered orally to patients suffering from chronic
anterior uveitis at a dose of 375 mg three times a day for 12 weeks. One
group of 18 patients received curcumin alone, whereas the other group of
14 patients, who had a strong PPD reaction, in addition received
antitubercular treatment. The patients in both the groups started
improving after 2 weeks of treatment. All the patients who received
curcumin alone improved, whereas the group receiving antitubercular
therapy along with curcumin had a response rate of 86%. Follow up of all
the patients for the next 3 years indicated a recurrence rate of 55% in
the first group and of 36% in the second group. Four of 18 (22%) patients
in the first group and 3 of 14 patients (21%) in the second group lost
their vision in the follow up period due to various complications in the
eyes, e.g. vitritis, macular oedema, central venous block, cataract
formation, glaucomatous optic nerve damage etc. None of the patients
reported any side effect of the drug. The efficacy of curcumin and
recurrences following treatment are comparable to corticosteroid therapy
which is presently the only available standard treatment for this disease.
The lack of side effects with curcumin is its greatest advantage compared
with corticosteroids.
Curcumin is not toxic
Dose escalation of a
curcuminoid formulation.
BMC Complement Altern Med. 2006 Mar 17;6:10. Lao CD, Ruffin MT
4th, et al. Division of Hematology-Oncology, Department of Internal
Medicine, University of Michigan, 2150 CCGC, Ann Arbor, MI 48109-0930, USA
A dose escalation study was conducted to determine the maximum tolerated
dose and safety of a single dose of standardized powder extract, uniformly
milled curcumin (C3 Complex, Sabinsa Corporation). Healthy volunteers were
administered escalating doses from 500 to 12,000 mg. Seven of twenty-four
subjects (30%) experienced only minimal toxicity that did not appear to be
dose-related. No curcumin was detected in the serum of subjects
administered 500, 1,000, 2,000, 4,000, 6,000 or 8,000 mg. Low levels of
curcumin were detected in two subjects administered 10,000 or 12,000 mg.
The tolerance of curcumin in high single oral doses appears to be
excellent. Given that achieving systemic bioavailability of curcumin or
its metabolites may not be essential for colorectal cancer
chemoprevention, these findings warrant further investigation for its
utility as a long-term chemopreventive agent.
Curcumin
665 mg, 60 vegicaps
Curcumin
is the major component of Turmeric (Curcuma longa L.) and extensive
scientific research on Curcumin has demonstrated its potent antioxidant
properties. Through its antioxidant mechanisms, Curcumin supports colon
health, exerts neuroprotective activity and helps maintain a healthy
cardiovascular system.
Curcumin Research update
Curcumin modulates free radical quenching
in myocardial ischaemia in rats.
Manikandan P. Central Leather Research Institute, Adyar, Chennai 600020, India.Int J Biochem Cell Biol. 2004 Oct;36(10):1977-90.
Inhibition of colonic aberrant crypt foci by curcumin
in rats is affected by age.
Kwon Y, Malik M, Magnuson BA.Nutr Cancer. 2004;48(1):37-43.
Curcumin questions
Q. I'm currently taking 8 grams per day of curcumin with
Bioperine to deal with
a large breast cancer. The cancer seems larger and harder and it has been giving
me more discomfort. I have yet to find an actual human being that has used
curcumin to cure a breast cancer. It would be wonderful if I could read some
testimonials or even speak to someone that knows what happens during the healing
process. Do you have this information?
A. We are not aware of anyone who has cured or treated breast
cancer with curcumin, alone.
Q. Can you tell me about phenocane, a friend mentioned
it to me recently.
A. Phenocane appears to be the brand name used by several products
such as Phenocane by medpro Holland B.V., Phenocane by Oxylife, and Phenocane by
Golden Tones International. The main ingredient of Phenocane is curcumin. One
formula of Phenocane contains boswellia, nattokinase, and dl phenylalanine.
Q. I recently started taking curcumin and am wondering
if it can be given to dogs? I have an aging Jack Russell Terrier
that has a bad knee and sometimes limps. She weighs 13 pounds.
A. We don't have much experience with the use of curcumin or
supplements in dogs or other animals, but it would seem that a third or half a
capsule a day should not cause a problem, but to make sure the vet should be
consulted.
Q. I am a private practice veterinarian performing a
research trial utilizing curcumin in horses for various inflammatory conditions.
It is my understanding, that based on prior research, that curcumin
bioavailability is compromised and in turn the absorption and therapeutic blood
levels are low. I also understand that various research trials are demonstrating
the concurrent use of piperine, which enhances the absorption and
bioavailability. I am curious if your research supports this as well and if
there is any further information that you might have to support this fact.
A. We have not seen convincing research that indicates piperine is
needed for curcumin absorption or bioavailability. Almost all studies with
curcumin have not used any piperine, therefore we tend to understand that
curcumin works well by itself.
Q. I am 76 years old and had for several years suffered
from cold feet even in the summer. Several visits to different doctors and tests
did not find the cause and treatment. So I searched the internet and found a
product curcumin turmeric by Dr. Sahelian and that it raises body temperature. I
have been taking the curcumin turmeric supplements for two months and have
noticed quite an improvement after a couple of weeks while taking one capsule in
the morning and one in the evening. When I skipped a dose, the cold feeling came
back. I have been taking for the last tne years pills to control my blood
pressure but recently noticed that while taking both the blood pressure and the
curcumin turmeric, my blood pressure dropped below normal and I was having dizzy
spells. I have stopped the last five days the blood pressure pills while
continuing the curcumin turmeric and have been surprised to find out my blood
pressure has stabilized at 120 over 80.
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