Devil's Claw capsule

Extracts of Devil’s claw roots are widely used in Europe for rheumatic pain. Two of the active principles of Devil’s claw are harpagoside and harpagide. The mechanism of action of Devil’s claw is still unclear and disputed, however one study has found a correlation between serum harpagoside levels and the inhibition of leukotriene biosynthesis. The plant’s common name is attributed to its peculiar clawlike seedpods which are covered with small hooklike protuberances. You can buy Devils-Claw here.

Nature's Way Devil's Claw
Nature's Way Devil's Claw (Harpagophytum procumbens) has a large claw-like fruit and is also called Grapple Plant.  The root or "tuber" is considered medicinal and is preferred by herbalists because of its high concentration of the beneficial component harpagoside.

Recommendation: Take two devils claw capsules twice daily with   water at mealtimes.

 Devils Claw Supplement Facts
 Serving Size 2 Capsules
 Servings Per Container 45
Amount Per Serving             
Devil's claw, 700 mg dried extract (root)   
Devil's claw (root) 260 mg           
Standardized to: 1.5% Harpagoside

Other herbs helpful for joint aches
Glucosamine sulfate (from shellfish) - Glucosamine Sulfate is a popular ingredient in many joint health products
Chondroitin sulfate - the nutrient
Chondroitin-Sulfate is a popular ingredient in many joint health products
MSM nutrient
CMO complex also known as cetyl myristoleate. You can find
CMO here.
Boswellia is used in Ayurvedic medicine
Curcumin is an extract from the plant turmeric
Cat's claw extract comes from the Amazon jungle
Grape seed extract supplement


Devil's Claw benefits
Devil’s claw may be helpful for those who have chronic low back pain.
Devil’s claw may reduce the need for analgesic and non-steroidal anti-inflammatory therapy in those with knee or hip osteoarthritis.
In rats, the dried crude methanolic extract of Harpagophytum procumbens secondary roots caused a significant dose-dependent reduction of arterial blood pressure, and had anti-arrhythmic effect.

Devil's Claw side effects
Mild and infrequent gastrointestinal symptoms have been reported, but more side effects may be discovered with time.

Devil's Claw Research Update
Evaluation of acute and chronic treatments with Harpagophytum procumbens on Freund's adjuvant-induced arthritis in rats.

Andersen ML Universidade Federal de Sao Paulo, Rua Napoleao de Barros, 925, Vila Clementino, SP-04024-002 Sao Paulo, Brazil.
J Ethnopharmacol. 2004 Apr;91(2-3):325-30.
The extract of Harpagophytum procumbens (Devils claw), widely utilized in Europe and, more recently, in other countries, is traditionally indicated to treat inflammatory processes. Devils claw acts by way of interleukins and leukocyte migration to the painful and inflamed joint area. Chemically, its secondary tuberous roots contains iridoid glycosides, harpagogide, procumbide, and harpagoside, as the active principle. The purpose of the present study was evaluate the therapeutic potential as anti-inflammatory and analgesic agent in rat model of Freund's adjuvant-induced arthritis both in the acute and chronic phases. The animals were injected with Freund's adjuvant in sub-plantar tissue of the right posterior paw and randomly assigned in acute (25, 50, or 100 mg/kg) or chronic (100 mg/kg) treatments with Devils claw solution test or vehicle. Then, submitted to behavioral test and assessment of body weight and right paw's measurements. The results show that Devils claw extract increased the animals 'latency of paws' withdrawal, indicating a protective effect against the pain induced by the thermal stimulus, both in acute and chronic treatments. In addition to reduction in the right paw edema in the experimental groups when compared to control group. Thus, the data showed anti-inflammatory and peripheral analgesic properties of Devils claw extract with all doses tested, thus confirming its indication for inflammatory processes.

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