Feverfew plant grows widely across Europe and North America. The leaves of feverfew have been historically used for the therapy of fever and more recently migraine headaches. For centuries, healers relied on the feathery green leaves of feverfew (Tanacetum parthenium) to treat headaches, stomach upset, rheumatoid arthritis, and menstrual problems. The bright yellow and white blossoms of this flower, which grows wild throughout Europe and South America, emit a powerful aroma that was once thought to purify the air and prevent disease. Feverfew has also long been used in gardens to repel bees and various insects. And as its common name suggests, it was once popular for reducing fever. The herb was somewhat forgotten, however, until the late 1970s. That's when migraine sufferers started talking about feverfew's potential to ward off these often debilitating headaches. For more feverfew information.

Feverfew Supplement Facts:
Feverfew - 100 mg (Tanacetum parthenium) Flower and leaf standardized to contain 600 mcg of parthenolide

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What's in Feverfew plant?
Feverfew herb contains a range of compounds known as sesquiterpene lactones. Over 85% of these are a compound called parthenolide. The active ingredient in feverfew, parthenolide, specifically binds to and inhibits a protein which plays a role in the body's inflammatory process. Fever is part of the body's inflammatory response, and inflammation contributes to a range of ailments -- including migraine headaches. Parthenolide helps prevent excessive clumping of platelets and inhibits the release of certain inflammatory chemicals. Feverfew's active ingredient parthenolide specifically binds to and inhibits the protein IKK-beta, which plays a role in the body's inflammatory process. Fever is part of the body's inflammatory response, and inflammation contributes to a range of ailments--including migraines. Results of studies with feverfew in the therapy or prevention of migraine headaches have not been consistent.

Feverfew dosage
The routine dosage of feverfew is 100 to 300 mg up to four times a day, 0.2 to 0.4% parthenolide.
       
Enzymatic Therapy - Feverfew, 30 Capsules
Feverfew is stabilized and standardized to guarantee 600 mcg of parthenolide per capsule (verified by HPLC).  Parthenolide is feverfew's most beneficial compound.  Feverfew is made from feverfew flowers and leaves harvested when the plant is richest in Parthenolide content. Just one capsule daily provides the maximum value feverfew has to offer.

Feverfew study
German researchers report that feverfew extract has potential for migraine headache help. The researchers conducted a study with 170 migraine patients. At the beginning of the trial, migraine frequency was approximately five attacks over a 4-week period. The subjects were then randomly assigned to treatment with feverfew or placebo three times a day for up to 16 weeks. In the feverfew treatment group, migraine frequency declined by two attacks per month. In the placebo patients, the corresponding decrease was only one per month. Analysis of responder rates revealed that feverfew was 3 times more effective than placebo.    

Feverfew Summary
Feverfew is helpful to some migraine sufferers although a review of published studies does not support the view that feverfew is consistently effective.
   The dosage is about 100 to 150 mg of the freeze-dried powdered herb, containing at least 0.4% parthenolide, taken twice a day. Benefits may be noticed within a month or two. Exercise, B vitamins, and magnesium supplements may also help. Some migraine sufferers also notice benefits from a low gluten diet.

Origin of parthenolide name
The traditional use of feverfew was for the relief of menstrual cramps in young girls (parthenos means virgin in Greek).

Feverfew questions
Q. Could you kindly advise if you know of any trials using feverfew / parthenolide with dogs? I noted an article in New Scientist that parthenolide from feverfew had reacted on cancer stem cells. My little dog has bone marrow cancer. I know some human treatments and foods can have an adverse effect with dogs. Hence, on the one hand this may help him but on the other it may cause further problems. My vet knows nothing about the feverfew herb.
   A. Sorry but we don't study herbs in dogs or other animals.

Q. Was just reading with interest your article in feverfew. I have CML; a few of my friends are taking feverfew to supplement their Imatinib. In three distinct cases, they have had disease reversal when they seemed to be failing imatinib. Also, it may be important to note that parthenolide is fat soluble. So dissolving feverfew in a fat may make it even more bioavailable. I have read the research that states it is poorly bioavailable. I just don't buy that. It has been helping people with migraines for years.
   Update: I have just received my latest PCR results from my experimental use of feverfew and Curcumin together. My cancer load by PCR measure was cut from 1.812% to .821% Very substantial and this was on a four week cycle of the two natural compounds.

Q. Is feverfew plant an alternative to triptan drugs?
   A. It may be in many users, but triptan drugs appear to be more potent.

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