Buy Forskolin supplement - Does this extract help with asthma?

 Coleus forskohli is an important traditional Ayurvedic herb that has been a part of Indian medicine for centuries. In the 1970s, researchers isolated a chemically active ingredient in the herb and called it forskolin. Now available in supplement form, this extract has been tested in a number of conditions.

Buy Forskolin extract supplement - Coleus Forskohlii extract, 60 Capsules

 Forskolin extract is produced from the root of coleus forskohlii, an ancient Ayurvedic plant. Modern extraction and analytical techniques are used to produce the highest quality extract available. Each batch of coleus forskohlii extract is analyzed and guaranteed to contain a minimum of 18% forskolin.

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Supplement facts
Coleus Forskohlii root extract - 125 mg
Standardized to contain 10% forskolin (12.5 mg per capsule)
Suggested use: One capsule forskolin extract once daily before breakfast.

Mechanism of action, how it works
Forskolin is a diterpene from the roots of the Indian plant Coleus forskohli which directly activates the adenylate cyclase and raises cyclic AMP levels in a variety of tissues. Cyclic AMP is an important cell regulating compound. Once formed it activates many other enzymes involved in diverse cellular functions. Under normal situations cAMP is formed when a stimulatory hormone (e.g., epinephrine) binds to a receptor site on the cell membrane and stimulates the activation of adenylate cyclase. This enzyme is incorporated into all cellular membranes and only the specificity of the receptor determines which hormone will activate it in a particular cell. Forskolin appears to bypass this need for direct hormonal activation of adenylate cyclase. As a result of this direct activation of adenylate cyclase, intracellular cAMP levels rise. The physiological and biochemical effects of a raised intracellular cAMP level include: inhibition of platelet activation; inhibition of mast cell degranulation and histamine release; increased force of contraction of heart muscle; relaxation of the arteries and other smooth muscles; increased insulin secretion; and increased thyroid function.

Benefits
Over the years studies have shown that forskolin is a platelet aggregation inhibitor, relaxes vascular smooth muscle, decrease intraocular pressure due to glaucoma, and has anti-allergy potential since it inhibits IgE-mediated release of histamine and peptide leukotriene from human basophils and mast cells. It is a potent inhibitor of cancer metastasis in mice injected with malignant cells.
   In a study in psychiatry, researchers gave intravenous forskolin to four depressed and five schizophrenic patients. All four depressed patients showed a transient mood elevation or stimulation, as did two of the five schizophrenic patients. Forskolin has been found to be helpful in asthma patients.

Forskolin ocular drops have been used to decrease intraocular pressure due to glaucoma
May be beneficial as a bronchodilator and anti-allergy agent.
Supplements may reduce blood pressure.
Forskolin is a United States Food and Drug Administration nonapproved vasoactive agent that acts in synergism with prostaglandin E1 to induce smooth muscle relaxation. In combination with other vasoactive agents, forskolin has demonstrated preliminary safety and efficacy in patients with vascular impotence. A potent herb that helps with this condition is tongkat ali.

We are not aware of specific human studies regarding the role of forskolin supplements in erectile dysfunction as of June 2008.

Asthma benefit
Forskolin versus sodium cromoglycate for prevention of asthma attacks: a single-blinded clinical trial.
J Int Med Res. 2006.
To determine the efficacy of forskolin in preventing asthma attacks, we performed a single-blinded clinical study in children and adult out-patients at a public hospital in Mexico. Forty patients of either sex with mild persistent or moderate persistent asthma were assigned randomly to 6 months of treatment with forskolin at 10 mg a day orally (capsules) or with two inhalations of sodium cromoglycate every 8 h, i.e. three times a day. The number of patients who had asthma attacks during the treatment period was significantly lower among those receiving forskolin (40%) than among those receiving sodium cromoglycate (85%). Values of forced expiratory volume in 1 second and forced expiratory flow, mid-phase, A similar in the two groups during the treatment period. We conclude that forskolin is more effective than sodium cromoglycate in preventing asthma attacks in patients with mild persistent or moderate persistent asthma.

Birth control pill interaction
I was wondering if there is any known drug interaction between forskolin supplements and birth control pills? Or is there any reason to suspect an interaction?
   We have not seen such studies regarding its interaction with birth control pills or other pharmaceutical drugs, and we can't say for sure.

For eyes
I've been looking for forskolin eye drops and have written to SamiLab in India but have not received a reply. I have read about the drops from various sources. Can you tell me why they do not seem to be available? I've heard that the 1% solution is in use and a 2% solution is in development.
   We think that eye drops are not allowed to be sold over the counter in the USA.

Urinary tract infections
Duke University microbiologist Dr. Soman N. Abraham found that many E. coli bacteria (the ones responsible for a large number of bladder infections) hide in cells lining the bladder, out of reach of antibiotics. However, when the researchers injected forskolin directly into the bladder or intravenously, it appeared to expel the majority of "hiding" E. coli, thus exposing them to the antibiotics. This is important in order to prevent recurrent cystitis when the bacteria come out of hiding and cause another infection shortly after the first one is treated.
   Comments: Whether forskolin supplements taken orally help individuals with bladder infections is not clear as of January 2008. Even if it works in humans, we still need research to find out the ideal dosage, when to take it (before, during, or after antibiotic treatment) and how long to take it for.

 Enzymatic Therapy - Coleus Forskohlii Extract, 60 Capsules
 Coleus Forskohlii Extract is produced from the root of Coleus forskohlii, an ancient Ayurvedic plant. Coleus is the source of a unique substance known as forskolin.  Modern extraction and analytical techniques are used to produce the highest quality extract available. Each batch of Coleus Forskohlii Extract is analyzed and guaranteed to contain a minimum of 18% forskolin.

Dosage
Forskolin is available over the counter in pills and liquid in a variety of dosages, most commonly 50 mg herbal extract providing 9 mg forskolin. However research is limited on the appropriate dosages for different conditions. The forskolin content of Coleus root is typically 0.2% to 0.3%, therefore the forskolin content of crude coleus products may not be sufficient to produce a pharmacological effect. It is best to use standardized extracts which have concentrated the forskolin content.

questions
Q. As a medical student at the UMCG, Groningen (the Netherlands). I'm always interested in new info about everything that is medically related. Especially neurophysiology related. That's one reason that I read a book: Mind Boosters: Improve your mind, memory, and mood. But what I didn't find in the book is info about the second messenger cAMP, and it's influence on new memory formation. I'm mentioning this because a famous neuroscientist and professor of biochemistry (Dr. E.R.Kandel) is working on a drug that enhances the amount of cAMP by blocking phosphodiesterase 4. The amount of cAMP can also be enhanced by the use of a herb, Plectranthus barbatus, which contains forskolin. My question is the following: Do you think that forskolin is an memory-enhancer, and what about it's safety?
   A. We focus our research mostly on clinical studies of herbs when given to humans since biochemical data on herbal components tested in the laboratory or in animals often don't give us enough practical information on how the herb or supplement interacts when given to humans. As such, at this time we don't know what kind of memory effects forskolin or herbs containing forskolin will have on human memory. We believe that memory is influenced by a number of biochemical processes and it may be best to approach this area providing a number of different nutrients in small amounts rather than one herb or herbal component in a large amount.

Q. I would like to buy forskolin for a stubborn bladder infection - will use with antibiotics. I realise there is no definitive data - even as to whether the capsules work at all. However if someone wanted to take forskolin for a bladder infection, would you care to take a stab at what dosage and for how long I would take the forskolin?
   A. You ask a good question, and as you probably know human studies are not available to give us a clue. In these cases of not knowing the appropriate dosage, a safe option is to start with one capsule and every few days increase by one more until side effects occur or the condition is better. Medical supervision is suggested. Of course there is a great deal of individual response to herbs, and much depends on the overall health of a person, age, other supplements they are taking, other medicines used, the type of antibiotic, etc. Also, we have no idea how forskolin interacts with different antibiotics.

Q. given the research indicating that forskolin deceases body fat and increases lean body mass, whether there is any reason to think that taking forskolin could be unhealthy for those who already have plenty of lean body mass and little body fat; or whether there is reason to believe that the 'fat burning' effects would only apply to excess fat (and never essential fat.)
   A. We are not aware of clinical trials that have looked into the role of forskolin supplements in terms of fat burning.

Q. My wife is interested in taking Forskolin extract supplement to help her with her thyroid and weight loss. She currently takes replacement thyroid (125 mcg), are there going to be any interactions?
   A. It is difficult to predict interactions between medications and herbal extracts. A good option is to have medical supervision and begin with a portion of the forskolin capsule, perhaps a third and subsequently determine over time the appropriate dosage.

 I recently received a prescription from my doctor which includes Forskolin 100ug/mi for penile injection. The prescription is a quad mix ( custom) None of the compound pharmacies in the area have heard of forskolin. Can you tell me if you can supply the injectable liquid form. If not who can.
    We are not familiar with the injectable form of this herbal extract.

As a redhead I am intrigued by the pro-eumelanin effects of topical forskolin but I am not enthusiastic about the prospect of slathering myself with a creme every day; do you know if people taking the oral supplements have seen similar skin effects to the topical administrations, i.e. fair-skinned people actually tanning?
    We have not had any reports or feedback from users of forskolin supplements regarding skin tanning.

I am a student of srm university chennai tamilnadu, India. i would like to know the purchasing details of forskolin 100 gm powder? can you pls tell me the contacting address for ordering the drug.
    We only provide the finished bottles and capsules, not the bulk powder.

Is taking forskolin a bad idea if you suffer from acid-reflux disease?
    We have not seen any studies that indicate that this dietary supplement would make such symptoms worse.

I am interested in making a topical lotion from forskolin to see if it darkens my light, "type II" skin. If effective, the forskolin-generated tan might make sun exposure less likely to cause a sunburn. Can you recommend one or more methods of preparing the lotion? Or can you offer a source of information that teaches how to do so? I gather that it can be extracted in an alcohol tincture, which might be mixed with glycerin. But DMSO might help the active ingredient penetrate the skin. I understand that topical forskolin might be absorbed systemically and am comfortable with that. (I have taken capsules orally without any problem.) But my goal is to absorb it to the level of melanocytes at the dermal/epidermal border.
   This is an area we have not studied.