GABA side effects, GABA supplement, Does GABA work for anxiety ?

GABA or gamma-aminobutyric acid, discovered in 1950, is the most important and widespread inhibitory neurotransmitter in the brain. Excitation in the brain must be balanced with inhibition. Too much excitation can lead to restlessness, irritability, insomnia, and even seizures. GABA is able to induce relaxation, analgesia, and sleep. Barbiturates and benzodiazepines are known to stimulate GABA receptors, and hence induce relaxation. Several neurological disorders, such as epilepsy, sleep disorders, and Parkinson’s disease are affected by this neurotransmitter.

GABA supplement, 250 mg, 60 Capsules - Enzymatic Therapy

GABA is an important amino acid neurotransmitter in the brain.

Recommendations: One, two, or three GABA capsules once or twice daily.
GABA Supplement Facts:
GABA (Gamma-aminobutyric acid) -  250 mg *
* GABA daily value not established

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GABA is made in the brain from the amino acid glutamate with the aid of vitamin B6. GABA is available as a supplement in vitamin stores, but taking it in pill form is not always an effective way to raise brain levels of this neurotransmitter because GABA cannot easily cross the blood-brain barrier. Companies are searching for ways to place GABA in an oil base in order to ease its entry across this barrier. Having said this, I have spoken to a few people who feel that GABA helps reduce their anxiety. One user takes GABA in the morning and says it takes the edge off his anxiety, and the effects are noticed a few hours later.

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GABA anxiety research
There is little research regarding the use of GABA supplements in humans. We don't have a strong opinion regarding the effectiveness of GABA supplements for anxiety at this time although the early research looks promising.

Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans.
Biofactors. 2006;26(3):201-8. Department of Research and Development, Pharma Foods International Co. Ltd., Kyoto, Japan.
The effect of orally administrated gamma-aminobutyric acid GABA on relaxation and immunity during stress has been investigated in humans. Two studies were conducted. The first evaluated the effect of GABA intake by 13 subjects on their brain waves. Electroencephalograms (EEG) were obtained after 3 tests on each volunteer as follows: intake only water, GABA, or L-theanine. After 60 minutes of administration, GABA significantly increases alpha waves and decreases beta waves compared to water or L-theanine. These findings denote that GABA not only induces relaxation but also reduces anxiety. The second study was conducted to see the role of relaxant and anxiolytic effects of GABA intake on immunity in stressed volunteers. Eight acrophobic subjects were divided into 2 groups (placebo and GABA). All subjects were crossing a suspended bridge as a stressful stimulus. Immunoglobulin A (IgA) levels in their saliva were monitored during bridge crossing. Placebo group showed marked decrease of their IgA levels, while GABA group showed significantly higher levels. In conclusion, GABA could work effectively as a natural relaxant and its effects could be seen within 1 hour of its administration to induce relaxation and diminish anxiety. Moreover, GABA administration could enhance immunity under stress conditions.

Gaba Enzymatic Therapy
GABA is an important amino acid neurotransmitter in the brain.
GABA (Gamma-aminobutyric acid) 250 mg

GABA Email questions and answers
Q. I am a little concerned with some conflicting reports I have seen on GABA since I have started taking it. On the one hand a at first glance it sounded like a miracle supplement but the claims of increases in growth hormone I was slightly suspicious off, most adverts steal results and quotes from clinical drugs trials report "Increase HGH levels by 550%" etc When I read the more independent research on it, the doctors say, Yourself included (funnily enough this is not found in the commercial adverts) that GABA as a sport supplement, in powder form cannot transgress easily the brain/blood barrier so in reality, the GABA in your head, is the stuff your body produces naturally and nothing else. - Certainly amongst the guys I know taking it nobody taking it seemed to be turning into the hulk over night.

Q. I recently read an article on body building that claimed using Gaba in the amount of 5 grams daily will act to reduce body fat. Gaba was praised as the ultimate fat burner. During your research have you discovered Gaba to have any body fat reducing capabilities?
   A. I have not come across this research.

Q. I have found a significant amount of literature on the net saying that taking GABA between 2-5 grams per day leads to significant increases in HGH in the blood stream. I was wondering if this is true, and if so what the risks would be in taking it at such high levels.
   A. Long term risks of high dose gaba intake are unknown, and even if supplements of gaba raise hgh levels, we don't know for certain that raising hgh levels is beneficial or harmful in the long run.

Q. In one of the your books that I read I remember you writing that you didnt find the supplement gamma-aminobutyric acid(GABA) to be very effective for relieving anxiety and that this was most likely because GABA does not cross the blood-brain barrier easily.  I agree that Kava Kava or 5-HTP are probably better for anxiety for most people but can you tell me whether at higher doses and/or more frequent dosing GABA could penetrate the blood-brain barrier and increase intracellular GABA levels significantly?
   A. Higher doses may lead to GABA crossing the blood brain barrier, but I have not personally tested this on myself or with patients.

Q. How long does it take for gaba to start working in you blood stream?
   A. GABA is readily and quickly absorbed into the bloodstream, but it has difficulty in crossing the blood-brain barrier and hence, at its present form sold over the counter, is not a reliable way to relieve anxiety.

Q. Are there any reasons to be cautious about using GABA as a sleep aid? Because it is an essential amino acid, I wonder if there are any potential negative effects of taking GABA supplements (I've seen them from 100-750mg).
   A. My clinical experience with GABA does not indicate this nutrient to have much of an effect on sleep since it doesn't seem that it crosses the blood brain barrier that well.

 Q. I am currently taking a GABA supplement for relaxation. Will taking Mind-Power Rx have a stimulating effect and would it counter-act the effects of GABA?
   A. Yes Mind Power causes alertness and increased mental stimulation.

Q. Have you looked into Picamilon and it's mood altering properties?
   A. Picamilon appears to be a combination of GABA and nicotinic acid. We have not evaluated this medicine.

Q. I have read that high doses of GABA can cause seizures?
   A. We have not seen any research that indicates taking GABA supplements induces seizures. Unexpected reactions can occur when extremely high doses of various supplements are taken.

Q. I stopped taking Prozac about a year ago. After experiencing symptoms of depression along with anxiety and sleeplessness I have started taking Sam-e with favorable results. So far I have not had an increase in anxiety but because of the warnings on your website will possibly lower my dosage if this occurs. Can I take a sleep aid containing GABA along with the Sam-e? Do these contradict one another?
   A. SAM-e may cause insomnia in high doses and it is preferable to take less SAM-e than to have to counteract it with a sleep aid.

Q. I greatly appreciate the information you've posted on your website. In the interest of assisting, I'd like to offer come comments on jujube, which is discussed briefly on your site. I take supplements for health, focus, stress and assistance sleeping. To clarify the 'focus' issue, I periodically have trouble getting out of repeating 'thought' cycles. Sometimes the repeating thought is a song I heard on the radio, other times the repeating thought is something like 'gosh, this is a big problem'. Even though I consciously wish the repeating thought to go silent, it doesn't go away upon command. I describe this as 'getting into a thought rut' or 'my mental jukebox'. I've found GABA an effective way to exit the rut, but I am looking for other supplements so that I can take GABA holidays.

Q. I subscribe to many health newsletters, recently (in May 2007), one of them discussed GABA research, "Studies with synthetic GABA have shown that it does not cross the blood-brain barrier very well. That led to the assumption that virtually all of the GABA found in the brain is manufactured there and that supplemental GABA would not increase levels of GABA in the brain. That appears to be the case with synthetic GABA, but not with natural GABA in the form of PharmaGABA - a special form of GABA naturally manufactured from Lactobacillus hilgardii – the bacteria used to ferment vegetables in the preparation of the traditional Korean dish known as kimchi. Unlike chemically produced, synthetic GABA, natural PharmaGABA appears to be able to cross the blood brain barrier to produce relaxation. PharmaGABA is approved for use in Japan as an aid to conquer stress and promote relaxation. It is a very is a popular ingredient in function foods and beverages as well as dietary supplements designed to produce mental and physical relaxation, without inducing drowsiness. " Are you familiar with PharmaGABA?
   A. We have not heard of PharmaGABA, and a search on Medline did not reveal any mention of PharmaGABA. We did find a study on the oral administration of a GABA supplement. It appears that GABA may play a role when used as an oral supplement. The company that sponsored this study is Pharma Foods, and it makes sense that a product would be called PharmaGABA.

Q. What does Gaba do for the brain and body?
   A. GABA, as found in the body and brain, is a neurotransmitter that helps in relaxation. The drug Valium works by influencing GABA receptors on brain cells.

Q. Can GABA be effective when mixed with a pop-like drink?
   A. Although GABA itself is a chemical found in the brain, questions have been raised as to whether taking a supplement can cross the blood brain barrier. At this time it seems very little of an ingested GABA supplement crosses into the brain.

Q. How common is this drug?
   A. GABA is a natural nutrient, not a drug since I would consider a drug a substance foreign to the body. GABA is one of the major neurotransmitters, along with serotonin, dopamine, and norepinephrine.

Q. Are you aware of any other commercial products that contain GABA?
   A. There are dozens or hundreds of GABA products on the market sold by various supplement sellers.

Q. Might GABA supplementation be useful to those with essential tremor?
   A. We have not seen any studies testing GABA supplements for essential tremor control, so we don't know.

Q. I recently purchased a bottle of GABA because, upon doing some research, found information that led me to believe that it sometimes is helpful to a person who might be going from a social drinker to an every night, chronic drinker. I am hoping for some help to not feel anxious, or a need to have a glass of wine every nite. I'm hoping GABA will just nudge me into a better state of mind...as I work on breaking the habit. Some of what I've read is confusing as I'm not a scientist, so, in layman's terms, are my assumptions that GABA supplement use helps relieve alcohol craving fairly correct?
   A. We have not seen any human studies that indicate the use of a GABA supplement reduces alcohol drinking and we also have not had any feedback from GABA supplement users that it has been helpful in this condition.

Supplement information by Ray Sahelian, M.D.

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