GalantaMind
is a formulation featuring galantamine, a
phytonutrient extracted from the common snowdrop (Galanthus nivalis), daffodil
(Narcissus pseudonarcissus L.), and spider lily (Lycoris radiata), among other
plants.Galantamine
supplement benefit and side effects
Galantamine for alzheimer's
disease galantamine side effects
What is
galantamine?
Galantamine is a cholinergic medicine.
Galantamine can be isolated from several plants, including daffodil bulbs, but is now synthesized. Galantamine is available over the counter and also by prescription.
Galantamine offsets reductions in central
cholinergic neurotransmission in
Alzheimer's disease (AD) by specifically and reversibly
inhibiting acetylcholinesterase. This allows more acetylcholine to be available in
the brain. Galantamine is also a nicotinic receptor agonist. Another herbal
extract that has potential in the therapy of Alzheimer's disease is
Huperzine A.
Galantamine
side effects
Side effects of galantamine are similar to those of
other cholinesterase inhibitors, i.e. nausea, vomiting, diarrhea, abdominal pain, and
dyspepsia. Keep your dosage low.
Galantamine - Life Enhancement
GalantaMind
is a formulation featuring galantamine, a
phytonutrient extracted from the common snowdrop (Galanthus nivalis), daffodil
(Narcissus pseudonarcissus L.), and spider lily (Lycoris radiata), among other
plants.
As an acetylcholinesterase inhibitor, galantamine competitively blocks the premature, age-related breakdown of the natural neurotransmitter acetylcholine, an essential molecule that supports memory function. Unlike other acetylcholinesterase inhibitors, galantamine also enhances nicotinic receptor activity, an effect long known to influence memory and intellectual activity.
Galantamine Supplement Facts
Galantamine hydrobromide extract - 4 mg
Suggested Use: For adults only. Half or one
galantamine capsule in the
morning a few times a week with breakfast
* Galantamine daily value not established
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Alternative to galantamine
supplement
There are several herbs that have an influence on memory, including Huperzine A,
Bacopa Monniera
and the herb
Ginkgo biloba.
Galantamine for dementia
Efficacy and safety of
galantamine
in patients with dementia with Lewy bodies: a 24-week open-label study.
Dement Geriatr Cogn Disord. 2007. Edwards K, Royall D, Hershey L,
Lichter D, Hake A, Farlow M, Pasquier F, Johnson S. Alzheimer's Diagnostic and
Treatment Center, Bennington, VT
Dementia with Lewy bodies is a common dementia of the elderly. A significant
cholinergic deficit has been demonstrated that may be responsive to treatment by
cholinesterase inhibitors. A 24-week, open-label study was designed to assess
the efficacy and safety of galantamine in 50 patients with dementia. Galantamine
appears to be an effective and safe therapy for patients with Lewy boy dementia.
Galantamine Alzheimer's disease research
Being approved for the treatment of Alzheimer's
disease in both the US and in Europe, galantamine has potential
as therapy for dementia. Galantamine is currently not recommended for use
by young individuals.
Effects of Galantamine on Measures of Attention:
Results From 2 Clinical Trials in Alzheimer Disease Patients With Comparisons to
Donepezil.
Alzheimer Dis Assoc Disord. 2008 January/March;22(1):30-38.
Subjects with Alzheimer's disease were tested comparing the effects of
galantamine, an acetylcholinesterase inhibitor and postulated nicotinic receptor
modulator, and donepezil, an acetylcholinesterase inhibitor. Attention task
performance tended to improve early for galantamine treated subjects. A
consistent temporal pattern of improvement was not observed in donepezil-treated
subjects. Quantitative findings appeared more pronounced in subjects with
moderate Alzheimer's disease.
Galantamine's proposed action as a nicotinic receptor modulator may bear on
these findings.
The cognitive benefits of galantamine are sustained for at least 36 months: a
long-term extension trial.
Raskind MA. University of Washington School of Medicine Seattle 98108, USA.
Arch Neurol. 2004 Feb;61(2):252-6.
Alzheimer disease (AD) causes progressive cognitive and functional
decline over years. Although cholinesterase inhibitors have demonstrated
efficacy in studies lasting 3 to 6 months, little is known about long-term
therapy. To report the long-term cognitive effects of galantamine
hydrobromide given continuously for 36 months in AD patients. Subjects were 194 US patients with mild to moderate AD who had been randomized
to continuous galantamine therapy in either of 2 double-blind placebo-controlled
trials. Subjects subsequently received open-label continuous galantamine therapy
for up to 36 months. Effects on cognition were analyzed
as change from study enrollment baseline in scores on the Alzheimer's Disease
Assessment Scale-11-item cognitive subscale. Cognitive decline in galantamine-treated
subjects was compared with that in a clinically similar historical control
sample of AD patients who had received placebo for 12 months and with the
mathematically predicted decline of untreated patients over 36 months. The rate
of cognitive decline of patients who completed the entire 36-month trial was compared with that of patients who withdrew for any reason during the
long-term open-label extension. An inverted responder analysis was also
performed in 36-month completers. Patients treated continuously with galantamine for 36 months increased a meanof 10 points on the
Alzheimer's Disease Assessment Scale-11-item cognitive subscale-a substantially
smaller cognitive decline (approximately 50%) than that predicted for untreated
patients. Patients discontinuing galantamine therapy before 36 months had
declined at a similar rate before discontinuation as those completing 36 months
of treatment. Almost 80% of patients who received galantamine continuously for
up to 36 months seemed to demonstrate cognitive benefits compared with those
predicted for untreated patients. Cognitive decline over 36 months
of continuous galantamine treatment was substantially less than the predicted
cognitive decline of untreated patients with mild to moderate dementia. Thus,
the cognitive benefits of galantamine seemed to be sustained for at least 36
months. These findings suggest that galantamine slows the clinical progression
of AD.
For more galantamine information at Ray Sahelian, M.D. home web site
Galantamine
supplement questions
Q. Does galantamine supplement come in 12 mg dosage?
A. We only find it in 4 mg. There could be galantamine side
effects on higher dosages.
Q. Can you tell me whether the galantamine
supplement is synthetic or extracted from plants or a combination? If extracted,
what plants?
A. Galantamine is naturally extracted from the common snowdrop (Galanthus nivalis), daffodil
(Narcissus pseudonarcissus L.), and spider lily (Lycoris radiata).
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