GalantaMind
is a formulation featuring galantamine, a
phytonutrient extracted from the common snowdrop (Galanthus nivalis), daffodil
(Narcissus pseudonarcissus L.), and spider lily (Lycoris radiata), among other
plants.Galantamine
supplement benefit and side effects, available as a dietary supplement and as a
prescription medication
Alzheimer's
disease treatment, proper dosage, interactions with medications, a review of side effects
Galantamine is a cholinergic medicine.
It can be isolated from several plants, including daffodil bulbs, but is now synthesized.
It is available over the counter and also by prescription. It is a cholinesterase inhibitor and
allosteric potentiating ligand modulating presynaptic nicotinic acetylcholine
receptors.
Galantamine offsets reductions in central
cholinergic neurotransmission in
Alzheimer's disease (AD) by specifically and reversibly
inhibiting acetylcholinesterase. This allows more acetylcholine to be available in
the brain. It is also a nicotinic receptor agonist. Another herbal
extract that has potential in the therapy of Alzheimer's disease is Huperzine A. Research studies are published on a regular basis and this web page will update
these studies as they related to Alzheimer's disease. Side effects
will be discussed along with prescription Reminyl for dementia and how other
medications used for AD interact with over the counter galantamine supplements.
Galantamine
side effects, safety, danger
Side effects are similar to those of
other cholinesterase inhibitors, i.e. nausea, vomiting, diarrhea, abdominal pain, and
dyspepsia. Keep your dosage low.
buy galantamine,
GalantaMind by Life Enhancement
GalantaMind
is a formulation featuring galantamine, a
phytonutrient extracted from the common snowdrop (Galanthus nivalis), daffodil
(Narcissus pseudonarcissus L.), and spider lily (Lycoris radiata), among other
plants.
As an acetylcholinesterase inhibitor, it competitively blocks the premature, age-related breakdown of the natural neurotransmitter acetylcholine, an essential molecule that supports memory function. Unlike other acetylcholinesterase inhibitors, it also enhances nicotinic receptor activity, an effect long known to influence memory and intellectual activity.
Supplement Facts
buy
Galantamine hydrobromide extract - 4 mg
Suggested Use: For adults only. Half or one
galantamine capsule in the
morning a few times a week with breakfast
Do you have Galantamine herb from Snowdrop (galanthus
nivalis) in 4 mg without the B6 or choline?
At this time we only carry the GalantaMind product which does
have choline and B6.
Choline is a nutrient
can converts into aceytylcholine and is added in this nutritional brain
enhancer.
How is it made, where does it
come from?
Can you tell me whether the galantamine
supplement is synthetic or extracted from plants or a combination? If extracted,
what plants?
Galantamine is naturally extracted from the common snowdrop (Galanthus nivalis), daffodil
(Narcissus pseudonarcissus), and spider lily (Lycoris radiata).
Alternatives
There are several herbs that have an influence on memory, including Huperzine A,
bacopa monniera
and the herb
ginkgo biloba.
Alzheimer's disease research
Being approved for the treatment of Alzheimer's
disease in both the US and in Europe, galantamine has potential
as therapy for dementia. Galantamine is currently not recommended for use
by young individuals.
Effects of Galantamine on Measures of Attention:
Results From 2 Clinical Trials in Alzheimer Disease Patients With Comparisons to
Donepezil.
Alzheimer Dis Assoc Disord. 2008.
Subjects with Alzheimer's disease were tested comparing the effects of
galantamine, an acetylcholinesterase inhibitor and postulated nicotinic receptor
modulator, and donepezil, an acetylcholinesterase inhibitor. Attention task
performance tended to improve early for galantamine treated subjects. A
consistent temporal pattern of improvement was not observed in donepezil-treated
subjects. Quantitative findings appeared more pronounced in subjects with
moderate Alzheimer's disease.
Galantamine's proposed action as a nicotinic receptor modulator may bear on
these findings.
The cognitive benefits of galantamine are sustained for at least 36 months: a
long-term extension trial.
Raskind MA. University of Washington School of Medicine Seattle, USA.
Arch Neurol. 2004.
Subjects were 194 US patients with mild to moderate AD who had been randomized
to continuous galantamine therapy in either of 2 double-blind placebo-controlled
trials. Subjects subsequently received open-label continuous therapy
for up to 36 months. Effects on cognition were analyzed
as change from study enrollment baseline in scores on the Alzheimer's Disease
Assessment Scale-11-item cognitive subscale. Cognitive decline in galantamine-treated
subjects was compared with that in a clinically similar historical control
sample of AD patients who had received placebo for 12 months and with the
mathematically predicted decline of untreated patients over 36 months. The rate
of cognitive decline of patients who completed the entire 36-month trial was compared with that of patients who withdrew for any reason during the
long-term open-label extension. An inverted responder analysis was also
performed in 36-month completers. Patients treated continuously with galantamine for 36 months increased a mean of 10 points on the
Alzheimer's Disease Assessment Scale-11-item cognitive subscale-a substantially
smaller cognitive decline (approximately 50%) than that predicted for untreated
patients. Patients discontinuing galantamine therapy before 36 months had
declined at a similar rate before discontinuation as those completing 36 months
of treatment. Almost 80% of patients who received galantamine continuously for
up to 36 months seemed to demonstrate cognitive benefits compared with those
predicted for untreated patients. Cognitive decline over 36 months
of continuous galantamine treatment was substantially less than the predicted
cognitive decline of untreated patients with mild to moderate dementia. Thus,
the cognitive benefits of galantamine seemed to be sustained for at least 36
months. These findings suggest that galantamine slows the clinical progression
of AD.
Dementia
benefit
Efficacy and safety of
galantamine
in patients with dementia with Lewy bodies: a 24-week open-label study.
Dement Geriatr Cogn Disord. 2007.
Dementia with Lewy bodies is a common dementia of the elderly. A significant
cholinergic deficit has been demonstrated that may be responsive to treatment by
cholinesterase inhibitors. A 24-week, open-label study was designed to assess
the efficacy and safety of galantamine in 50 patients with dementia. Galantamine
appears to be an effective and safe therapy for patients with Lewy boy dementia.
Dosage and availability over
the counter
Does galantamine supplement come in 12 mg dosage?
We only find it in 4 mg. There could be adverse
effects on higher dosages.
Combining with other dietary
supplements and herbs
Is there a danger combining
tongkat ali
herb with galantamine pill?
Yes, it could lead to sweating and severe insomnia.
Is it safe to take it along with sam e for arthritis pain
and Diet Rx.
They are both potent supplements and we prefer users not take
them the same day.
Shipping overseas
Can you
ship GalantaMind to Belgium? I've been in trouble for shipping melatonin before.
We have not had this product returned by customs, but we
can't predict what customs will do sometimes in foreign countries.