Hydroxycitrate HCA is an active ingredient that is extracted from the rind of the Indian fruit, Garcinia cambogia, which is available as an herbal supplement and promoted as a weight loss agent. Chronic administration of garcinia extract promotes lipid oxidation and spares carbohydrate utilization.
Natrol Pure Citrimax,
Hydroxycitric Acid derived from Garcinia Cambogia
Natrol
Pure CitriMax is derived from the dried rind of Garcinia Cambogia, a
native fruit of India. CitriMax contains high concentrations of hydroxycitric acid, verified by HPLC to guarantee potency and
quality.
CitriMax Supplement Facts:
Hydroxycitric Acid HCA - 250 mg
(Standardized extract from Garcinia cambogia fruit)
Click here to buy Garcinia cambogia extract CitriMax
For a natural sugar alternative, consider stevia benefit information.
Does apple
cider vinegar diet work?
Garcinia extract research
Garcinia cambogia is able to decrease the acidity and to increase the mucosal defense in
the gastric areas, thereby justifying its use as an anti-ulcerogenic agent.
Garcinia extract was isolated from the fruit of the Garcinia cambogia and was used as a
potential antiobesity agent. In week 3 of culture with insulin, the fat cells exhibited
more numerous and larger intracytoplasmic lipid droplets. When Garcinia extract and insulin were added simultaneously, the accumulation of lipid droplets
was inhibited and the peak droplet area shifted to become smaller. The
activities of glycerophosphate dehydrogenase, a marker of adipose differentiation, were
not significantly inhibited by the garcinia extract. These findings suggest that the
Garcinia extract inhibits lipid droplet accumulation in fat cells without affecting
adipose conversion.
1998 Garcinia extract article in JAMA
Hydroxycitric acid, the active ingredient in the herbal compound Garcinia
cambogia, competitively inhibits the extramitochondrial enzyme adenosine
triphosphate-citrate (pro-3S)-lyase. As a citrate cleavage enzyme that may play an
essential role in de novo lipogenesis inhibition, G cambogia is claimed to lower body
weight and reduce fat mass in humans. To evaluate the efficacy of Garcinia
extract
for body weight and fat mass loss in overweight human subjects. Twelve-week
randomized, double-blind, placebo-controlled trial. Overweight men and women subjects (mean body mass index
[weight in kilograms divided by the square of height in meters], approximately 32 kg/m2).
Subjects were randomized to receive either active herbal compound (1500 mg
of hydroxycitric acid per day) or placebo, and both groups were prescribed a high-fiber,
low-energy diet. The treatment period was 12 weeks. Garcinia
cambogia failed to produce significant weight loss and fat mass loss beyond that observed
with placebo.
Summary and side effects
Garcinia extract, by itself, is unlikely to lead to
weight loss,
but in combination with other nutrients and herbs it may have potential.
No major side effects have been reported in medical publications.
Garcinia Cambogia
extract Research study
Effects of hydroxycitric acid on appetitive variables.
Mattes RD, Bormann L. Purdue University, 212 Stone Hall, West
Lafayette, IN 47907-1264, USA.
Physiol Behav. 2000 Oct 1-15;71(1-2):87-94.
Hydroxycitric acid (HCA) reportedly promotes weight loss, in part, through
suppression of hunger. However, this mechanism has never been evaluated in
humans in a controlled study. Eighty-nine mildly overweight females were
prescribed 5020-kJ diets for 12 weeks as part of a double-blind,
placebo-controlled parallel group study. Forty-two participants ingested 400-mg
caplets of Garcinia cambogia 30-60 min prior to meals for a total dose of 2.4
g/day (1.2 g/day HCA). Forty-seven participants ingested matched placebos.
Weight and body composition were assessed at baseline and every other week for
12 weeks. Food intake and appetitive variables were assessed at baseline and
monthly for 12 weeks. Both groups lost body weight with the active group
achieving a significantly greater reduction.
No effects of the HCA were observed on appetitive variables. The active
treatment group did not exhibit better dietary compliance or significant
correlations between appetitive variables and energy intake or weight change.
This study does not support a satiety effect of HCA.
Garcinia cambogia (hydroxycitric acid) as a
potential antiobesity agent: a randomized controlled trial.
Heymsfield SB. besity Research Center, St Luke's-Roosevelt Hospital, Columbia
University College of Physicians and Surgeons, New York, NY 10025, USA.
Hydroxycitric acid, the active ingredient in the herbal compound
Garcinia cambogia, competitively inhibits the extramitochondrial enzyme
adenosine triphosphate-citrate (pro-3S)-lyase. As a citrate cleavage enzyme that
may play an essential role in de novo lipogenesis inhibition, G cambogia is
claimed to lower body weight and reduce fat mass in humans. To
evaluate the efficacy of Garcinia cambogia for body weight and fat mass loss in
overweight human subjects. Twelve-week randomized, double-blind,
placebo-controlled trial.
Overweight men and women subjects (mean body mass index [weight in
kilograms divided by the square of height in meters], approximately 32 kg/m2). Subjects were randomized to receive either active herbal compound
(1500 mg of hydroxycitric acid per day) or placebo, and both groups were
prescribed a high-fiber, low-energy diet. The treatment period was 12 weeks.
Body weight was evaluated every other week and fat mass was measured at weeks 0
and 12. Body weight change and fat mass change.
A total of 135 subjects were randomized to either active hydroxycitric acid or placebo ; 42 (64%) in the active hydroxycitric acid group and 42
(61%) in the placebo group completed 12 weeks of treatment. Patients
in both groups lost a significant amount of weight during the 12-week treatment
period; however, between-group weight loss differences were not
statistically significant.
There were no significant differences in estimated percentage of body fat mass
loss between treatment groups, and the fraction of subject weight loss as fat
was not influenced by treatment group. Garcinia cambogia failed to
produce significant weight loss and fat mass loss beyond that observed with
placebo.
Garcinia cambogia
extract
supplement inquiries
Q. I read about your articles in the internet about Garcinia combogia extract. I would
like to ask for your advice. I'm taking Garcinia combogia and xenadrine nrg (which
i get it from the GNC outlet's nutritionist) with Xenical (given by my doctor).
Just to ask for your opinion, is it Ok for me to take it like that?
A. We cannot say since different people react differently and
the dose makes a big difference. All we do is provide general research on these
supplements and it is up to the consumer and their doctor to decide.
Q. I am considering ordering some
supplement products. However, I presently have a supplement product called Super
Citrimax with 750 mg. It includes kelp and ginseng under the product name of
NOW. I have high blood pressure, and noticed after taking it I had dry mouth and
my blood pressure elevated for no unknown reason. I had only eaten lightly
through the day with miso soup for dinner. Do you know if the garcinia cambogia
or ginseng which is in some of products could interact with a rise in blood
pressure? My physician does not have the answer for he does not know about
herbal complexes.
A. We are not certain how garcinia influences blood pressure, but
ginseng may raise blood pressure in some people if the dosage is high. The
influence of most of these herbs is dose related, meaning low dosages would not
have much of an influence on blood pressure whereas high dosages would. It may
be an option to take half of a capsule of this garcinia ginseng combination.
Garcinia extract benefits will be reviewed on a regular basis as more studies are published, see Supplements and Herbal Index