Grape seed extracts have compounds called procyanidolic oligomers (PCOs). Other sources of PCOs are berries, green and black teas, and red wine. PCOs are powerful antioxidants, perhaps much greater than vitamins C and E. They also inhibit a number of enzymes that degrade connective tissue such as elastase, collagenase, and hyaluronidase.

Grape Seed Extract supplement, 100 mg
Joint Power Rx with Grape Seed Extract
Grape Seed Extract is a natural plant product made from the grape seed (or pip). Grape Seed Extract is rich in procyanidins, a special class of water-soluble bioflavonoids which are excellent free radical scavengers.

Grape Seed Extract Supplement Facts
Grape Seed Extract - 100 mg *

Suggested Use: 1 to 2 grape seed extract tablets a few times a week, or as recommended by your health care professional.

* Grape seed extract daily value not established.

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Benefits grape seed extract for medical uses
The primary clinical indications for grape seed extract are the treatment of such vascular disorders as hypertension, venous insufficiency and capillary fragility and possibly retinal maladies such as diabetic retinopathy and macular degeneration. PCOs may improve night vision.

Grape Seed additional benefits
Moderately high amounts of grape seed extract may blunt salt-sensitive hypertension.
Grape seed extract may be helpful as an antioxidant in smokers. In lab studies, grape seed extract was beneficial in protecting white blood cell DNA from damage.

Grape seed extract and allergy
Grape seed extract does not provide relief for allergic symptoms such as stuffy nose, sneezing and itchy, and watery eyes.

Skin cancer and grape skin extract
Chemicals found in grape seeds may help ward of skin cancer due to regular exposure to the sun. Researchers from the University of Alabama, Birmingham exposed hairless mice to ultraviolet-light. Some of the mice they fed a standard diet supplemented with grape seed proanthocyanidins, while control mice were fed a standard diet without this supplement. Dietary supplementation with grape seed extract inhibited light-induced carcinogenesis, study. Mice supplemented with grape seed extract had up to 65 fewer skin cancer tumors than control mice did. Moreover, the tumors seen in grape seed extract -supplemented mice were smaller than those seen in the control mice. Grape seed extracts appear to inhibit suppression of the immune system caused by ultraviolet light. Grape seed extract has antioxidant activity, and UV-induced oxidative stress has been linked to the induction of skin cancers. Over exposure to sunlight accounts for more than one million new cases of melanoma and non-melanoma skin cancers each year in the United States. Effective preventive agents and strategies that can reduce or control the risk of UV-induced skin cancer could help the general population.

Grape seed extract not helpful after breast cancer radiation
Double-blind, placebo-controlled, randomised phase II trial of IH636 grape seed proanthocyanidin extract (GSPE) in patients with radiation-induced breast induration.
Radiother Oncol. 2006 April. Department of Radiotherapy, Royal Marsden Hospital, Sutton, Surrey, UK.
Tissue hardness (induration), pain and tenderness are common late adverse effects of curative radiotherapy for early breast cancer. The purpose of this study was to test the efficacy of IH636 grape seed proanthocyanidin extract in patients with tissue induration after high-dose radiotherapy for early breast cancer in a double-blind placebo-controlled randomised phase II trial. Sixty-six eligible research volunteers with moderate or marked breast induration at a mean 10.8 years since radiotherapy for early breast cancer were randomised to grape seed extract supplement or placebo. All patients were given proanthocyanidin grape seed extract 100 mg three times a day orally, or corresponding placebo capsules, for 6 months. The study failed to show efficacy of orally-administered grape seed extract in patients with breast induration following radiotherapy for breast cancer.

Grape Seed Research
Effect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokers.
Vigna GB. University of Ferrara, Ferrara, Italy.
Metabolism. 2003 Oct;52(10):1250-7.
The aim of our study was to evaluate the effect of a standardized formulation of a polyphenolic extract of grapes (Leucoselect-Phytosome) on low-density lipoprotein (LDL) susceptibility to oxidation in a group of heavy smokers. A randomized, double-blind, crossover study was undertaken in 24 healthy male heavy smokers, aged > or = 50 years. Enrolled subjects were given 2 capsules twice daily for 4 weeks (phase 1). Each capsule contained 75 mg of a grape procyanidin extracts and soy-phosphatidlcholine or placebo consisiting of 75 mg lactose and soy-phosphatidlcholine. A wash out period of 3 weeks was then followed by 4 weeks of the opposite treatment (phase 2). Blood samples were taken at baseline and at the end of each phase and assayed for plasma lipids and LDL susceptibility to oxidation. Compliance was good, and no adverse effects were recorded. Subjects did not show significant modification of total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C) and LDL-C during LP treatment. Among oxidative indices, thiobarbituric acid reactive substances (TBARS) concentration was significantly reduced in subjects taking grape seed extract, and the lag phase prolonged compared with placebo and basal values. The antioxidant potential of grape seed extract polyphenols may prove effective in a model of oxidative stress (smoking); however more investigational data are needed before use in wider clinical settings.

Grape seed extract activates Th1 cells in vitro.
Clin Diagn Lab Immunol 2002 Mar;9(2):470-6
Although flavonoids manifest a diverse range of biological activities, including antitumor and antiviral effects, the molecular mechanisms underlying these activities await elucidation. We hypothesize that the flavonoid constituents of a proprietary grape seed extract that contains procyandins exert significant antiviral and antitumor effects, by inducing production of the Th1-derived cytokine gamma interferon (IFN-gamma) by peripheral blood mononuclear cells) from healthy donors. Our results show that grape seed extract significantly induced the transcription of IFN-gamma mRNA as demonstrated by reverse transcription-PCR but had no effect on the Th2-derived cytokine interleukin-6. The enhancing effect of grape seed extract on IFN-gamma expression was further supported by a concomitant increase in the number of cells with intracytoplasmic IFN-gamma as well as the synthesis and secretion of IFN-gamma. Our results demonstrate that the potentially beneficial immunostimulatory effects of grape seed extract may be mediated through the induction of IFN-gamma.

Grape seed extract emails
Q. Is it safe to take grape seed extract and fish oil capsules at the same time? I've heard that they both cause blood thinning.
   A. There are no clear cut answers. Much depends on the rest of one's diet, other supplements taken, other medicines taken such as aspirin, a person's inherent clotting status, age, and most importantly dosage of the supplements. In most cases there should be no problem with combining grape seed extract and fish oils, but each case is different and you are your doctor would need to make the final decision.

Q. I have got a disease called “Institutional Lungs Disease” and more popularly known as “LUNGS FIBROSIS”. Currently I am on Prednisolone tablet taking 10 MG every day after breakfast besides other medicines to decrease the side effects of Steroids. I have been told that if I start taking nutritional medicine, the disease can be either cured or the lungs damage which have already happened will not increase further. Is it correct? Further, I am told that the Grape Seed Extract Capsule will be of much use. In view of the above, could you please suggest me which product should I take and of which company so that I improve my health to cure this disease as well as get rid of steroids.
   A. We are not familiar with the nutritional treatment of this lung disease.

Q. Which grape seed extract is pure? What should the dose be? any side-effects? are there any interactions with grape seed extract and medications or supplements? My patient has Parkinson's disease and is on Sinemet every 1 hr during the day. Any concerns about grape seed extract in this situation?
   A. We are not aware of human studies with grape seed extract that have evaluated these topics.

Q. I read that if you combine vitamin C with grapeseed extract it will raise your blood pressure. Is this true to the best of your knowledge?
   A. We have not seen any evidence that combining vitamin C with grapeseed extract raises blood pressure.

Q. I received a promotional email that said: "Grape Seed Extract contains Oligomeric Proanthocyanidins, which is a set of bioflavonoid complexes that perform as free radical scavengers in human body. Nowadays, grape seed extract is a very popular dietary supplement and a powerful free radical scavenger better than vitamins C,E and beta-carotene. Main Function of grape seed extract : Prevents skin aging and inhibits UV radiation, Enhanced capillary strength and vascular function, Penetrates the blood-brain barrier to help protection of the brain and nerve tissue from oxidation, Alleviates PMS problems, bruising, edema from injury or trauma, varicose veins, leg swelling and retinopathy." Are these grape seed extract claims true?
   A. Some of these grape seed extract benefits may be true but there is not enough human research to claim with certainty that this supplement is effective for PMS symptoms, bruising, edema, varicose veins, leg swelling and retinopathy. There is a possibility that further research could prove a grape seed extract to be of benefit in retinopathy and other medical conditions, but it is too early to make such claims.

Q. I am in need of liquid grape seed extract to make a natural fruit and veggie wash. I "Googled" it & am having no luck.
   A. Sorry we are not familiar with a liquid grape seed extract product.




Besides extract powder (Proanthocyanidins >95%), Herbasin also has 500mg
softgel capsule for your different requirement.

 

Passion Rx with no ginseng grape seed research grapeseed immune system

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