Nature's
Way
Guggul (6% Guggulsterones E &Z), 60 Vcaps
-
Nature's
Way
Guggul Extract ( Commiphora mukul) is
standardized to 6% guggulsterones E & Z. Guggul has been clinically
shown to promote cardiovascular health.
Recommendation: Take 1
guggul capsule two or three times daily with food or water.
Guggul extract Supplement Facts:
Guggul extract - 425 mg
(gum resin), 6% guggulsterones E & Z
* Guggul Daily Value not established
Guggul extract Supplement Facts:
Guggul extract - 425 mg
(gum resin), 6% guggulsterones E & Z
* Guggul Daily Value not established
Guggul and Inflammation
Guggul also has anti-inflammatory activity.
One study reports that it may be beneficial in osteoarthritis.
Myrrhanol A, a new triterpene isolated from guggul (Balsamodendron or
Commiphora mukul Hook.)-gum resin, displays a potent anti-inflammatory effect.
Guggul dosage
The dosage of guggulsterones is 25 mg two or three times daily. Most extracts contain
2.5–5% guggulsterones and can be taken daily for 3 to six months.
Guggul summary
Herbal extracts from Commiphora mukul (guggul)
have been widely used in Asia as cholesterol-lowering agents, and their
popularity is increasing in the United States.
Guggul appears to be beneficial in those who have metabolic syndrome which
includes high blood lipids, high blood sugar, obesity, and an overall
inflammatory pattern.
Guggul and prostate cancer
Guggulsterone-induced apoptosis in human prostate cancer cells is caused by
reactive oxygen intermediate dependent activation of c-Jun NH2-terminal kinase.
Cancer Res. 2007 August. Singh SV, Choi S, Zeng Y, Hahm ER, Xiao D.
Department of Pharmacology and Urology and University of Pittsburgh Cancer
Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora
mukul, causes apoptosis in cancer cells but the sequence of events leading to
cell death is poorly understood. We now show that guggulsterone-induced cell
death in human prostate cancer cells is caused by reactive oxygen intermediate (ROI)-dependent
activation of c-Jun NH(2)-terminal kinase (JNK). The present study reveals that
the guggulsterone-induced cell death in human prostate cancer cells is regulated
by ROI-dependent activation of JNK and guggulsterone inhibits promoter activity
of androgen receptor.
Nature's
Way
Guggul (Standardized 6%
Guggulsterones E &Z)
Guggul Extract ( Commiphora mukul) is
standardized to 6% guggulsterones E & Z. Guggul has been clinically shown to
promote cardiovascular health.*
Guggul, dried extract (gum resin), 6% guggulsterones E & Z
Other cholesterol lowering agents
Pectin, whether from apple
or
Pectin-Grapefruit, could be helpful to lower cholesterol.
Guggul Research
Update
Guggulipid for the treatment of hypercholesterolemia: a
randomized controlled trial.
Szapary PO. niversity of Pennsylvania School of Medicine,
Philadelphia 19104-6021, USA.
JAMA. 2003 Aug 13;290(6):765-72.
Recently, guggulsterones, the purported bioactive compounds of
guggul, have been shown to be potent antagonists of 2 nuclear hormone receptors
involved in cholesterol metabolism, establishing a plausible mechanism of action
for the hypolipidemic effects of these extracts. However, there are currently no
published safety or efficacy data on the use of guggul extracts in Western
populations. To study the short-term safety and efficacy of 2 doses
of a standardized guggul extract (guggulipid, containing 2.5% guggulsterones) in
healthy adults with hyperlipidemia eating a typical Western diet.
Double-blind, randomized, placebo-controlled trial using a parallel design,
conducted March 2000-August 2001. A total of 103
ambulatory, community-dwelling, healthy adults with hypercholesterolemia in the
Philadelphia, Pa, metropolitan area. Oral, 3 times daily doses of
standard-dose guggul (1000 mg), high-dose guggul (2000 mg), or matching
placebo. Compared with participants randomized to placebo (n = 36), in
whom levels of LDL-C decreased by 5%, both standard-dose guggul and
high-dose guggul raised levels of LDL-C by 4%
and 5%, respectively, at 8 weeks, for a net positive change
of 9% to 10%. There were no significant changes in levels of total cholesterol, HDL-C, triglycerides, or VLDL-C in response to treatment with guggul in the
intention-to-treat analysis. While guggul was generally well tolerated, 6
participants treated with guggul developed a hypersensitivity rash compared
with none in the placebo group. Despite plausible mechanisms of
action, guggul did not appear to improve levels of serum cholesterol over
the short term in this population of adults with hypercholesterolemia, and might
in fact raise levels of LDL-C. Guggulipid also appeared to cause a dermatologic
hypersensitivity reaction in some patients.
The effectiveness of Commiphora mukul (guggul) for osteoarthritis of
the knee: an outcomes study.
Altern Ther Health Med. 2003 May-Jun;9(3):74-9.
Singh BB,.
Southern California University of Health Sciences, USA.
Ayurveda, the traditional system of healthcare in India, has many
remedies for Osteoarthritis (OA). One of the ingredients most commonly found in
Ayurvedic arthritis formulas is guggul, an oleoresin of the herb Commiphora
mukul. The authors have conducted both preclinical and clinical
investigations of guggul for reduction of pain, stiffness, and improved
function, and to determine tolerability in older patients with a diagnosis of OA
of the knee. The study was conducted using an outcome,
quasi-experimental, model. Thirty male and female participants meeting the
inclusion/exclusion criteria, with a score of 2 or more on the Kellegran-Lawrence
scale for at least 1 knee, were admitted in the study. Guggul was administered in
capsule form (500 mg concentrated exact delivered TID) along with food. The
WOMAC Total Score was used as a primary outcome measure. VAS scales, 6-minute
walk-test, and WOMAC subscales were used as outcome measures. At the
end of treatment, there was a significant difference in the scores of the
primary and secondary outcome measures. On the primary measure, WOMAC total
score, participants were significantly improved after taking the
supplement for 1 month and continued to improve at the 2-month marker and
follow-up. Secondary measures of pain in the VAS format demonstrated participant
improvement; however, mood state, and current pain were not significantly
different than baseline until the 2 month assessment. Overall data indicate significant improvement for participants
during the trial in both scales and objective measures used for assessment
purposes. There were no side effects reported during the trial. Guggul appears to be
a relatively safe and effective supplement to reduce symptoms of OA.
Guggul supplement
questions
Q. I was diagnosed with Hypothyroid, based on symptoms and a TSH of 8.71. All
other scores for T3 and T4 were within the normal range, indicating that the
thyroid was working, albeit under duress. After reading information on guggul, I
began dosing with guggul (for healing) and L tyrosine ( to supply the raw
materials). A month later, my bloodwork was redone. TSH scores were reduced to
4.66. I suspect that if I had continued on the guggul, they would have continued
to fall, but I opted at that point to take Synthriod. Doctor asked me to
discontinue guggul, claiming the guggul had produced a "false reading" of 4.66.
Additionally I asked for an antibody test, and discovered Hashimoto's to be the
cause of my thyroiditis.
Q. Specifically what is the action of guggul on the thyroid? Possibilities :
Guggul's anti-inflammatory effects quiets the auto-immune response of
Hashimoto's. This permits the thyroid to heal. The lower TSH levels are the
result of a recovering thyroid producing T4. (good). Guggul simply replaces TSH,
lowering the response of the pituitary, as the thyroid continues to struggle to
produce T4.(not good)
A. We have not seen any good human studies evaluating the role of
guggul supplements and their influence on the thyroid gland. We found studies in
mice which generally indicates that guggul may stimulate T3 production..
Thyroid Stimulating Action of Z Guggulsterone
Obtained from Commiphora mukul.
Planta Med. 1984 February. Department of Kayachikitsa, Institute of Medical
Sciences, Banaras Hindu University, Varanasi-221005, India.
A ketosteroid has been isolated from the oleo-resin of guggul Commiphora mukul.
The isolated ketosteroid showed a strong thyroid stimulatory action when
administered to albino rats. Its administration brought about an increase in
iodine-uptake by thyroid and enhanced activities of thyroid peroxidase and
protease as well as oxygen consumption by isolated slices of liver and biceps
muscle.
Guggul Commiphora mukul potentially
ameliorates hypothyroidism in female mice.
Phytother Res. 2005 Jan. Thyroid Research Unit, School of Life Sciences, D.
A. University, Khandwa Road, Indore-452017 (M.P.), India.
The efficacy of guggul, the gum resin of Commiphora mukul in regulating
hypothyroidism was evaluated in female mice. In addition to estimating serum
levels of thyroxine and triiodothyronine, hepatic 5' monodeiodinase, hepatic
glucose-6-phospatase and lipid-peroxidation (LPO), the activities of the
anti-oxidative enzymes, superoxide dismutase (SOD) and catalase (CAT), were
investigated. Findings suggest the possible use of guggulu in the amelioration
of hypothyroidism.
guggul supplement.
Guggul extract
questions
Q. Can a guggul extract be taken together with
Arginine supplement?
A. We have not seen studies with this combination.
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