Icariin
and erectile enhancement
Icariin, a flavonol glycoside, is an interesting substance found in
certain herbs, particularly
horny goat weed.
Icariin and Erections
Icariin appears to have some properties similar to Viagra. Icariin is a cGMP-specific PDE5 inhibitor that may
have potential in treating erectile dysfunction. Additional herbs helpful for
sexual improvement include
Tongkat-Ali-LJ100 and
Maca.
For more information on
erectile
dysfunction. Also consider
Tongkat-Ali.
Epimidium Sagittatum with icariin
Epimedium
sagittatum contains icariin. In China it is
especially used for supporting healthy sexual activity - thus its name,
Horny goat weed.
Epimedium sagittatum 400 mg has epimedium extract (standardized to 10% flavonoids as icariin).
Epimedium sagittatum with icariin supplement
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Additional benefits of Icariin
In laboratory studies, icariin appears to have anti- cancer abilities. Icariin
also helps protect the liver from toxicity and DNA from damage.
Protective effect of icariin on DNA against
radical-induced oxidative damage.
J Pharm Pharmacol. 2007 December. Department of Organic Chemistry,
College of Chemistry, Jilin University, Changchun 130021, China.
The major objective of this work is to determine the antioxidative effect of
icariin against oxidative DNA damage induced by 2,2'-azobis(2-amidinopropane)
dihydrochloride. We found that icariin protects DNA against AAPH-induced
oxidative damage in a concentration-dependent manner, although it does not
affect the rate of AAPH-induced DNA damage. This result indicates that icariin
is a concentration-dependent chemopreventor in protecting DNA against
radical-induced damage.
Icariin and
phosphodiesterase activity for erectile dysfunction
Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic
guanosine monophosphate level in cavernous smooth muscle cells.
Urology. 2006 Dec;68(6):1350-4. Ning H, Xin ZC, et al. Knuppe Molecular
Urology Laboratory, Department of Urology, University of California, San
Francisco, School of Medicine, San Francisco, California 94115, USA.
To investigate the effect of icariin on the cyclic guanosine
monophosphate (cGMP)-hydrolytic activity of phosphodiesterase-5 (PDE5) isoforms
and the cGMP levels in cavernous smooth muscle cells treated with sodium
nitroprusside (SNP). PDE5 isoforms (PDE5A1, A2, and A3) were isolated from sf9
insect cells infected with baculoviruses carrying PDE5 isoform cDNA. Icariin was
isolated from Epimedii herba. Icariin was inhibitory to all three PDE5 isoforms
with similar IC50 values, which were approximately three times greater than
those for zaprinast. Icariin was able to enhance cGMP levels in sodium
nitroprusside -treated cavernous smooth muscle cells.
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