Source Naturals IP-6 supplement


IP6 - Inositol Hexaphosphate
Supports Breast, Colon & Prostate Cells

IP-6 (inositol hexaphosphate) is a component of certain dietary fibers, particularly most cereal grains, legumes, and seeds high in oil. Many researchers believe that some of fiber's health benefits may be due to the antioxidant, immune enhancing, and cardiovascular supporting activities of IP-6. In-vitro and animal research has shown IP-6 to have significant protective and growth regulating effects on various cells and tissues including those of the colon, breast, and prostate.

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IP-6 and cancer
IP-6 has been reported to have in vivo and in vitro anti cancer activity against numerous tumors, such as colon, prostate, breast, liver, chronic myeloid leukemia, and rhabdomyosarcomas. Significant human trials are lacking and hence we do not currently know whether taking IP-6 supplements is helpful in cancer prevention or therapy.

IP-6 and cancer research
Dietary administration of inositol and/or inositol-6-phosphate prevents chemically-induced rat hepatocarcinogenesis.
Asian Pac J Cancer Prev. 2005 Jan-Mar;6(1):41-7. Nutrition Science Lab., Department of Food and Nutrition, Seoul National University, Seoul 151-742, Korea.
Chemoprevention is considered a rational strategy for dietary approaches to prevention of cancer. Multiple lines of evidence suggest that many of our dietary principles are able to intervene in the multistage carcinogenesis process and phytic acid ( inositol hexaphosphate, IP6 ), a phytochemical present in a variety of plant species, has been shown to prevent various cancers, including those of the mammary gland, colon and liver. However, the mechanism of chemoprevention by IP6 has not been fully elucidated. In the present study, we examined the effects of inositol and/or IP6 supplementation on rat hepatocarcinogenesis initiated by diethylnitrosamine (DEN) and promoted by partial hepatectomy (PH). Supplementation with either inositol or IP6, or their combination, starting one week prior to administration of DEN, resulted in a significant decrease in both the area and the number of placental glutathione S-transferase positive (GST-P+) foci, a preneoplastic marker for DEN-initiated hepatocarcinogenesis. The administration of inositol and/or IP6 in drinking water caused marked enhancement in the glutathione S-transferase (GST) activity. In addition, the production of thiobarbituric acid reactive substances and the catalase activity were significantly reduced in rats supplemented with inositol and /or IP6. Based on these findings, it is likely that the chemopreventive effects of inositol and/or IP6 on rat hepatocarcinogenesis initiated by DEN and promoted by PH are associated with induction of GST activity and suppression of lipid peroxidation.

IP-6 supplement questions
Q. I have been diagnosed with osteoporosis for the past 4 years. Will IP-6 remove good calcium from my body and worsen the condition of osteoporosis?
   A. We are not aware of IP-6 acting in this manner and have not seen any studies that suggest the use of the IP-6 supplement leads to osteoporosis.

Q. I am very interested in better health i am a cancer survivor lung cancer and can you tell me where to find more info on IP-6?
   A. Please see IP-6 info at this site.

Q. My brother has been taking the above IP-6 product for 4 months, since he got colon cancer. Are there any side effects or downside to taking IP-6 supplement every day. I heard that IP-6 might take the iron out of the system. Also that Petasites may not be good to take on a long term basis.
   A. We don't have enough human experience with IP-6 to know for sure.

Q. I have stage IV GIST. Is IP-6 an effective treatment? I am currently being treated at Memorial Sloan Kettering, Dr. Gary Schwartz and Dana-Farber, Dr. George Demetri, and I am taking 400mg Gleevec daily. Gleevec is used to treat Chronic Myeloid Leukemia (CML) and Gastrointestinal Stromal Tumors (GIST). Do you know how IP-6 interacts with Gleevec?
   A. We wish there were more human studies with IP-6 supplement, but since there aren't we really can't say how effective IP-6 is in terms of Gastrointestinal Stromal Tumors. We have no idea if or how IP-6 would interact with Gleevec. We have no idea if IP-6 interacts with Gleevec.

Q. Was wondering if you could tell me, does IP-6 increase the levels or ATP like Co-Q10 or decrease it like Protocel?
   A. We are not familiar with Protocel. A search on Medline with the keywords IP-6 and ATP does not show any published studies that would give us a clue.

Q. I have recently begun taking Inositol Hexaphosphate supplement and i have headaches as side effect. Is this a common side effect when one begins taking IP-6 supplement? The dosage I am taking is 800 mg per day. I am being tested for breast cancer and my father, a true believer in alternative therapies, recommended IP-6 product.
   A. Different people experience different side effects from supplements and medicines. As of November 2007, we have not had anyone mention to us that IP-6 supplement caused headaches.

Q. Can inositol hexaphosphate be used to aide in polycystic kidney disease or renal failure?
   A. We searched the medical literature and could not find studies regarding the use of IP-6 for kidney failure or polycystic kidney disease.

Q. My four-year-old son has a rare bone disorder called Ollier's disease ( enchondromatosis ) that causes benign cartilaginous tumors to form inside the bones as he grows. There is no known cure for the disorder yet - except various surgeries to try to correct resulting deformities. Because of the risk of cancer associated with this condition, I'm very interested in anti-cancer supplements for my son. A nutritionist I contacted suggested the possibility of using IP-6 as a therapy for a child. The anti-proliferative qualities of IP-6 might be of interest in relation to the growth of bone tumors. I realize there is most likely no scientific data available that is directly relevant, but I wondered if there is any anecdotal info -- isolated cases of children taking IP-6. Would you assume that it's safe and plausibly effective for children? What dose would be recommended for a forty-pound child?
   A. We have not seen any studies with the use of IP-6 regarding its use in children. It is difficult to know whether IP-6 would help, and if it does in what dosage and whether there are long term risks to using this supplement. If IP-6 were to be used, your health care provider would have to make the final decision since we are not aware of human studies or anecdotes regarding the long term use of this supplement in adults or children. We wish your son the best outcome.

Q. Hello... I have used IP 6 in the past on a pet and I truly believed her life was prolonged by years because of this product. I now have a dog with a confirmed diagnosis of GME Encephalitis, a immune mediated disease. Chemo and anti rejection drugs are the only treatment in the hopes of possible remission. Presently he is taking: prednisone lomustine cytarabine leflunomide cyclosporine. Although he is doing well, he relapses when the prednisone dosage is dropped. He must get off the prednisone soon or he will begin deteriorating from the side effects of that drug. The whole purpose is to shut down the immune system so it will stop attacking the brain. Would the use of IP 6 in this case be beneficial or would it act to stimulate the immune system? I had such good results with IP-6 supplement  before I thought maybe I could try it in this case.
   A. Unfortunately we are not familiar with the use of IP-6 supplement in pets, particularly when combined with prednisone and other cancer medications.
 

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