IP-6 supplement used as alternative cancer pill, a review of benefits and side effects, published trials

March 28 2014

Inositol hexaphosphate (
IP-6), is a naturally polyphosphorylated carbohydrate found in beans, brown rice, corn, sesame seeds, wheat bran, and other high fiber foods. It aids in the metabolism of insulin and calcium, hair growth, bone marrow cell metabolism, eye membrane development, and helps the liver transfer fat to other parts of the body. Synthesis of inositol 1,2,3,4,5,6-hexakisphosphate (IP(6)), also known as phytate, is integral to cellular function in all eukaryotes.

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IP6 - Inositol Hexaphosphate natural product
Supports Breast, Colon and Prostate Cells

Inositol hexaphosphate is a component of certain dietary fibers, particularly most cereal grains, legumes, and seeds high in oil. Many researchers believe that some of fiber's health benefits may be due to the antioxidant, immune enhancing, and cardiovascular supporting activities of IP-6. In-vitro and animal research has shown IP-6 to have significant protective and growth regulating effects on various cells and tissues including those of the colon, breast, and prostate.

 

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Cancer research

IP-6 has been reported to have in vivo and in vitro anti cancer activity against numerous tumors, such as colon, prostate, breast, liver, chronic myeloid leukemia, and rhabdomyosarcomas. Significant human trials are lacking and hence we do not currently know whether taking IP-6 supplements is helpful in cancer prevention or therapy.

Dietary administration of inositol and/or inositol-6-phosphate prevents chemically-induced rat liver cancer.
Asian Pac J Cancer Prev. 2005.
Chemoprevention is considered a rational strategy for dietary approaches to prevention of cancer. Multiple lines of evidence suggest that many of our dietary principles are able to intervene in the multistage carcinogenesis process and phytic acid ( inositol hexaphosphate, IP6 ), a phytochemical present in a variety of plant species, has been shown to prevent various cancers, including those of the mammary gland, colon and liver. However, the mechanism of chemoprevention by IP6 has not been fully elucidated. In the present study, we examined the effects of inositol and/or IP6 supplementation on rat hepatocarcinogenesis initiated by diethylnitrosamine and promoted by partial hepatectomy (PH). Supplementation with either inositol or IP6, or their combination, starting one week prior to administration of diethylnitrosamine, resulted in a significant decrease in both the area and the number of placental glutathione S-transferase positive (GST-P+) foci, a preneoplastic marker for DEN-initiated hepatocarcinogenesis. The administration of inositol and/or IP6 in drinking water caused marked enhancement in the glutathione S-transferase (GST) activity. In addition, the production of thiobarbituric acid reactive substances and the catalase activity were significantly reduced in rats supplemented with inositol and /or IP6. Based on these findings, it is likely that the chemopreventive effects of inositol and/or IP6 on rat hepatocarcinogenesis initiated by diethylnitrosamine and promoted by PH are associated with induction of GST activity and suppression of lipid peroxidation.

Pancreatic cancer
Inositol hexaphosphate IP6 : a novel treatment for pancreatic cancer.
J Surg Res. 2005.
Inositol hexaphosphate IP6 is a naturally occurring polyphosphorylated carbohydrate found in food sources high in fiber content. IP6 has been reported to have significant inhibitory effects against a variety of primary tumors including breast and colon. The effects of IP6 have not been evaluated in pancreatic cancer. We hypothesized that IP6 would significantly inhibit cell growth and increase the apoptotic rate of pancreatic cancer in vitro. Treatment of pancreatic cancer with the common dietary polyphosphorylated carbohydrate IP6 significantly decreased cellular growth and increased apoptosis. Our findings suggest that IP6 has the potential to become an effective adjunct for pancreatic cancer treatment. Further in vivo and human studies are needed to evaluate safety and clinical utility of this agent in patients with pancreatic cancer.

Stomach cancer
Q. I have stage IV GIST. Is IP-6 an effective treatment? I am currently being treated at Memorial Sloan Kettering, Dr. Gary Schwartz and Dana-Farber, Dr. George Demetri, and I am taking 400mg Gleevec daily. Gleevec is used to treat Chronic Myeloid Leukemia (CML) and Gastrointestinal Stromal Tumors (GIST). Do you know how IP-6 interacts with Gleevec?
   A. We wish there were more human studies with IP-6 supplement, but since there aren't we really can't say how effective IP-6 is in terms of Gastrointestinal Stromal Tumors. We have no idea if or how IP-6 would interact with Gleevec. We have no idea if IP-6 interacts with Gleevec.

Side effects, long term use
My brother has been taking the above IP-6 product for 4 months, since he got colon cancer. Are there any side effects or downside to taking IP-6 supplement every day. I heard that it might take the iron out of the system. Also that Petasites may not be good to take on a long term basis.
   We don't have enough long term human experience with IP-6 to know for sure.

I have recently begun taking Inositol gexaphosphate supplement and i have headaches as side effect. Is this a common when one begins taking it? The dosage I am taking is 800 mg per day. I am being tested for breast cancer and my father, a true believer in alternative therapies, recommended  the natural product.
   Different people experience different side effects from supplements and medicines. As of 2014, we have not had anyone mention to us that IP-6 supplement caused headaches.

Mechanism of Action, how it works
In addition to reducing cell proliferation, IP6 increases differentiation of malignant cells, often resulting in a reversion to normal phenotype. Orally administered IP6 is rapidly taken into the cells and dephosphorylated to lower-phosphate inositol phosphates, which further interfere with signal transduction pathways and cell cycle arrest. Enhanced immunity and antioxidant properties can also contribute to tumor cell destruction. However, the molecular mechanisms underlying this anticancer action are not fully understood. Because it is abundantly present in regular diet, efficiently absorbed from the gastrointestinal tract, and safe, IP6 holds great promise in strategies for the prevention and treatment of cancer. IP6 enhances the anticancer effect of conventional chemotherapy, controls cancer metastases, and improves the quality of life.
     IP6 inhibits human platelet aggregation in vitro.

Osteoporosis
Q. I have been diagnosed with osteoporosis for the past 4 years. Will IP-6 remove good calcium from my body and worsen the condition of osteoporosis?
   A. We are not aware of IP-6 acting in this manner and have not seen any studies that suggest the use of the IP-6 supplement leads to osteoporosis.

 

Q. Was wondering if you could tell me, does IP-6 increase the levels or ATP like Co-Q10 or decrease it like Protocel?
   A. We are not familiar with Protocel. A search on Medline with the keywords IP-6 and ATP does not show any published studies that would give us a clue.

Q. Can inositol hexaphosphate be used to aide in polycystic kidney disease or renal failure?
   A. We searched the medical literature and could not find studies regarding its use for kidney failure or polycystic kidney disease.

Q. My four-year-old son has a rare bone disorder called Ollier's disease ( enchondromatosis ) that causes benign cartilaginous tumors to form inside the bones as he grows. There is no known cure for the disorder yet - except various surgeries to try to correct resulting deformities. Because of the risk of cancer associated with this condition, I'm very interested in anti-cancer supplements for my son. A nutritionist I contacted suggested the possibility of using IP-6 as a therapy for a child. The anti-proliferative qualities of IP-6 might be of interest in relation to the growth of bone tumors. I realize there is most likely no scientific data available that is directly relevant, but I wondered if there is any anecdotal info -- isolated cases of children taking IP-6. Would you assume that it's safe and plausibly effective for children? What dose would be recommended for a forty-pound child?
   A. We have not seen any studies with the use of IP-6 regarding its use in children. It is difficult to know whether IP-6 would help, and if it does in what dosage and whether there are long term risks to using this supplement. If IP-6 were to be used, your health care provider would have to make the final decision since we are not aware of human studies or anecdotes regarding the long term use of this supplement in adults or children. We wish your son the best outcome.

I have used IP 6 in the past on a pet and I truly believed her life was prolonged by years because of this product. I now have a dog with a confirmed diagnosis of GME Encephalitis, a immune mediated disease. Chemo and anti rejection drugs are the only treatment in the hopes of possible remission. Presently he is taking: prednisone lomustine cytarabine leflunomide cyclosporine. Although he is doing well, he relapses when the prednisone dosage is dropped. He must get off the prednisone soon or he will begin deteriorating from the side effects of that drug. The whole purpose is to shut down the immune system so it will stop attacking the brain. Would the use of IP 6 in this case be beneficial or would it act to stimulate the immune system? I had such good results with IP-6 supplement  before I thought maybe I could try it in this case.
    Unfortunately we are not familiar with the use of IP-6 supplement in pets, particularly when combined with prednisone and other cancer medications.

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