Methyl B12 supplements

A methyl donor is simply any substance that can transfer a methyl group [a carbon atom attached to three hydrogen atoms (CH3)] to another substance. Many important biochemical processes rely on methylation, including the metabolism of lipids and DNA. Scientists suspect that adequate methylation of DNA can prevent the expression of harmful genes, such as cancer genes. It’s quite likely that our body’s ability to methylate declines with age, contributing to the aging process, and therefore supplementation could well be beneficial. The research in this area is still very early and no firm answers are yet available. Trimethylglycine is a methyl donor supplement available for sale. DMG supplement pill is used for mood and immune system improvement.

Benefit
These substances help in the production of several brain chemicals and hence improve mood, energy, wellbeing, alertness, concentration, and visual clarity. A few people notice enhanced sexual enjoyment. They may be helpful in age related cognitive decline, Alzheimer’s disease, fighting depression, and overall health maintenance. They may perhaps also be helpful in Parkinson’s disease.
Dopamine neurotransmitter levels may be influenced by such supplementation.

Methyl donor supplement emails
Can a methyl donor lead to male enhancement?
   Some may increase libido, but we don't have any evidence that they would increase penis size.

Q. While I have read yours and others overview on the positive function of methylation, detox of estrogens and homocysteine, etc, and I have read studies that associate a lack of methylation with cancer, there are studies that find cancers express high levels of methylation. Methylation has been found to supress ERb, which is considered a tumor supressor. There is even a patent filed by Baylor University on methylation depletion as a cancer therapy. Methionine (which wasnt listed as a methyl donor on your site, but is a primary one that is a constituent of SAM-e supplement, has been found to fuel tumors and considered unsafe for cancer patients. Can you comment on methylation and methyl donors in regard to cancer?
   A. We have not seen enough human research regarding the administration of methyl donors in varying dosages over long periods of time to know how they would influence formation of cancer. Perhaps different methyl donors have different influences. Perhaps the dosage could make a significant difference. There are too many unknowns at this point to know for certain how the use of methyl donors taken as supplements influence cancer prevention or formation. For the time being it is a good idea for those who take methyl donor supplements on a daily basis to take breaks from use for instance one week a month.

Products seized
In May 2009, the U.S. Food and Drug Administration seized more than 23,300 bottles of dietary supplement products because of a safety risk. The supplements would be destroyed because they contain unapproved food additives and-or new dietary ingredients for which there is inadequate information to assure they do not present a significant or unreasonable risk of illness or injury. The products -- distributed by LG Sciences LLC of Brighton, Mich. -- were marketed for use by body builders and distributed on the Internet and in retail stores under the names "Methyl 1-D," "Methyl 1-D XL" and "Formadrol Extreme XL." "The FDA has no scientific information concerning the safety of the condemned products or their ingredients and, thus, cannot determine whether they represent a hazard to consumers," the agency said. "Under the circumstances, consumers who use or have used the products should discuss their use with their health care professionals." The ingredients in Formadrol Extreme include:Anti-Aromatase Complex 27mg: Adrostan-3-alpha-ol-170-one, Adrostan-3-beta-ol-170-one, SERM Complex 178mg:Ellagic Acid, Ginger Extract, Piperine and Quercetin.
 

Supplements and Herbal Index