Mucuna pruriens side
health benefit, l dopa content, for Parkinson's, neurological conditions and libido enhancement
March 7 2014
Mucuna pruriens, commonly known as velvet bean, contains L-Dopa which is used to make dopamine, an important brain chemical involved in mood, sexuality, and movement of the body. Studies in rats show supplementation to increase dopamine content in the cortex of the brain. It is used for male erectile dysfunction, as an aphrodisiac, and as nervine tonic. This plant has been used for generations in India to treat Parkinson's disease, which has a low prevalence in India except in the small Parsi community where there is a high prevalence. Parkinson's disease has been known in India since ancient days and the powder of mucuna pruriens seeds has been used for its treatment. This herbal remedy also has antioxidant properties.
buy Mucuna Pruriens herb suitable for vegetarians
Formulated by Ray Sahelian, MD
Mucuna Pruriens herb - 200 mg
Mucuna pruriens seed dried water extract, 15 percent L Dopa which converts into dopamine.
You can buy at Amazon Mucuna 200mg
Directions: Take one capsule in the morning or as directed by your health care provider.
Buy Mucuna Pruriens herb
Composition and constituents
Nutritional analysis reveals mucuna pruriens seed contains crude protein ranged from 20-29 %, crude lipid 6-7%, total dietary fibre 8-10%, ash 3% and carbohydrates 50-60%.
Besides L-dopa, some mucuna pruriens supplements contain quite a number of others substances including tetrahydroisoquinoline alkaloids, D-chiro-inositol and its galacto-derivatives, trace amounts of bufotenine, DMT, and beta-carboline.
herb side effect, adverse events, safety
The benefits and side effects of long term use of mucuna pruriens supplements in humans are not known, therefore users and their doctors should be vigilant for any symptoms or signs that could relate to a potential long term side effect.
Mucuna pruriens in Parkinson's disease: a double blind clinical and pharmacological study.
J Neurol Neurosurg Psychiatry. 2004.
We assessed the clinical effects and levodopa (L-dopa) pharmacokinetics following two different doses of mucuna preparation and compared them with standard L-dopa / carbidopa. Eight Parkinson's disease patients with a short duration L-dopa response and on period dyskinesias completed a randomised, controlled, double blind crossover trial. Patients were challenged with single doses of 200/50 mg L-dopa / carbidopa, and 15 and 30 g of mucuna pruriens preparation in randomised order at weekly intervals. Compared with standard L-dopa / carbidopa, the mucuna preparation led to a considerably faster onset of effect, reflected in shorter latencies to peak L-dopa plasma concentrations. No significant differences in dyskinesias or tolerability occurred. The rapid onset of action and longer on time without concomitant increase in dyskinesias on mucuna seed powder formulation suggest that this natural source of L-dopa might possess advantages over conventional L-dopa preparations in the long term management of Parkinson's disease.
Neuroprotective effects of the
antiparkinson drug Mucuna pruriens.
Phytother Res. 2004.
Mucuna pruriens possesses significantly higher antiparkinson activity compared with levodopa in the 6-hydroxydopamine (6-OHDA) lesioned rat model of Parkinson's disease. The present study evaluated the neurorestorative effect of Mucuna pruriens cotyledon powder on the nigrostriatal tract of 6-OHDA lesioned rats. Mucuna pruriens cotyledon powder significantly increased the brain mitochondrial complex-I activity but did not affect the total monoamine oxidase activity (in vitro). Unlike synthetic levodopa treatment, Mucuna pruriens cotyledon powder treatment significantly restored the endogenous levodopa, dopamine, norepinephrine and serotonin content in the substantia nigra. Nicotine adenine dinucleotide (NADH) and coenzyme Q-10, that are shown to have a therapeutic benefit in Parkinson's disease, were present in the Mucuna pruriens cotyledon powder. Earlier studies showed that Mucuna pruriens treatment controls the symptoms of Parkinson's disease. This additional finding of a neurorestorative benefit by Mucuna pruriens cotyledon powder on the degenerating dopaminergic neurons in the substantia nigra may be due to increased complex-I activity and the presence of NADH and coenzyme Q-10.
Mucuna pruriens is not having the hoped for result. My wife has Parkinson's and
takes about 300 mg per day Roche's Prolopa 200/50 mg formulation. We tried
adjusting it to that level, but a full week of experimentation did not give an
improvement -- in fact, just the opposite. Looks like I'll use it for my libido
which it does help a lot!
The dosage of mucuna pruriens may not have been enough, or it could have interacted with Prolopa, or perhaps you wife just would not respond to it. Not everyone responds positively to medications or herbal supplements.
Infertility, sperm function
Effect of Mucuna pruriens on semen profile and biochemical parameters in seminal plasma of infertile men.
Fertility Sterility. 2007.
We evaluated sixty normal healthy fertile men (controls) and 60 men with infertility. Before and after the treatment, seminal plasma lipid profile, lipid peroxide, fructose, and antioxidant vitamin levels were measured. Treatment with mucuna pruriens significantly inhibited lipid peroxidation, elevated spermatogenesis, and improved sperm motility. Treatment also recovered the levels of total lipids, triglycerides, cholesterol, phospholipids, and vitamin A, C, and E and corrected fructose in seminal plasma of infertile men. Treatment with mucuna pruriens increased sperm concentration and motility in all the infertile study groups.
PLoS One. 2013. Mucuna pruriens and its major constituent L-DOPA recover spermatogenic loss by combating ROS, loss of mitochondrial membrane potential and apoptosis. Division of Endocrinology, Council for Scientific and Industrial Research-Central Drug Research Institute, Lucknow, India. The Ayurvedic medicinal system claims Mucuna pruriens (MP) to possess pro-male fertility, aphrodisiac and adaptogenic properties. Some scientific evidence also supports its pro-male fertility properties; however, the mechanism of its action is not yet clear. The present study aimed at demonstrating spermatogenic restorative efficacy of MP and its major constituent L-DOPA (LD), and finding the possible mechanism of action thereof in a rat model.
I read online that mucuna pruriens helps some people with restless leg syndrome (which I have had for over 20 years). I am presently on Requip, which works great, if, Iím ready to go to sleep. However, my RLS begins around 8pm at night once I sit down. If I take the Requip, I can not stay awake with my family for it makes me SO sleepy. Up to now, I just walk the floors until time to take Requip since it is just impossible to sit and relax. I would like to try something for the RLS that does not make me drowsy. I have no other medical problem except for the RLS. Now to the question: You have several products which have the mucuna pruriens. I want to take the one that has the ďHighestĒ amount of the herb in it. Which of your products would you advise? How would you suggest I convert from Requip to mucuna? Or do I take both. One in morning, one at bedtime? The pure mucuna has 200 mg. Does the Passion Rx or Eyesight Rx, have more mucuna? Do you think something else would work better?
Passion Rx and Eyesight Rx have small amounts of the herb, so the pure herb would be the choice if you wanted a large amount. We have not seen studies that have evaluated the role of this herb in terms of restless legs syndrome treatment so we don't know how well it works, and if it does, what the appropriate dosage would be. Also, we have not seen studies that have evaluated the combination of this herb with the prescription medication ropinirole, so we don't know if the combination of the herb mucuna pruriens and ropirinole would be of benefit or cause side effects. There is much still to be learned about this medical condition and its natural treatment and interactions.
enhancement, effect on libido
Studies in rodents indicate that the use of this herb has sexual enhancing properties. This herb can be used in small dosages together with other herbs used for sexual enhancement, including catuaba, horny goat weed, muira puama, yohimbe, and tongkat ali.
I recently purchased mucuna pruriens for my orgasm problem but it didn't seem
to help so I thought I'd ask if there are any other items you would recommend
instead. I take forever to reach orgasm. All I see for men are products to delay
orgasm - that is not what I need and any of those serotonin products would make
things far worse for me. I I tried mucuna as an attempt to see if dopamine
insufficiency might be my issue. At this point I can't tell if it is or isn't
(I've only been taking it for four days).
It's difficult to predict which herb or herbal combination will help since this area has not been studied. But it would be fair to give each herb or product a period of at least one to two week trial. Other products to try would include Passion Rx, LJ100, and tribulus terrestris. For more information, see Natural Sex Boosters book.
Influence on hormone
Numerous commercial sites claim that mucuna pruriens herbal product will increase levels of testosterone, GH, GnRH, LH, and FSH. Are there any studies available that verify these claims?
Mucuna pruiriens increases dopamine levels which can influence hormone secretion. Not enough studies have been done in humans to know which hormones are influenced and for how long and whether different dosages lead to different hormone influences.
I read that it can raise testosterone
levels, and being a woman, should this be a concern for me? I am working to
correct some neurological imbalances and want to try a product we carry in the
supplement store I work at. I am 27 years old and also take 5-HTP, but would
like to use mucuna pruriens in addition to that. My only concern would be any
unnecessary hormonal changes.
Neurological imbalances is a very ambiguous diagnosis. We have not seen any good human studies regarding the influence of mucuna pruriens on hormone levels.
Effect on neurotransmitters
It is widely believed that mucuna pruriens influences the dopamine system, however there may be other factors involved. A study was designed to elucidate the long-term effect on neurotransmitters in various regions of the rat brain. Mucuna pruriens powder at a dose of 2.5, 5.0 or 10.0 grams /kg/day was mixed with rat chow and fed daily ad lib to Sprague-Dawley rats for 52 weeks. Controls received no mucuna pruriens. The rats were sacrificed at the end of 52 weeks and the neurotransmitters were analyzed in the cortex, hippocampus, substantia nigra and striatum. Oral administration of mucuna pruriens endocarp in the form of HP-200 had a significant effect on dopamine content in the cortex with no significant effect on levodopa, norepinephrine or dopamine, serotonin, and their metabolites- HVA, DOPAC and 5-HIAA in the nigrostriatal tract. The failure of Mucuna pruriens endocarp to significantly affect dopamine metabolism in the striatonigral tract along with its ability to improve Parkinsonian symptoms in the 6-hydorxydopamine animal model and humans may suggest that its anti-parkinson effect may be due to components other than levodopa or that it has an levodopa enhancing effect.
drugs, medication interaction
I am currently taking 20mg of adderall xr, not everyday, but a couple times a week. I take it when I know I'm going to have a busy day at work or have a lot of things to get done at home. I don't take it everyday to avoid any side effects and to not become too immune to its effects. I was reading about mucuna pruriens product and its ability to increase dopamine and I was wondering if this product alone or in combination with L-Tyrosine would be a suitable substitute for the days I don't take the adderall. Perhaps your product might be a suitable replacement for adderall altogether. Please let me know as I am interested in trying the herb.
It is difficult to predict what would happen in any one individual, but we suggest not taking the supplement the same day as the medication.
I am currently taking Madopar at 100mg, I would like
to reduce my dosage to 50 mg. Could I take mucuna with Madopar together?
Madopar is a prescription medication that contains two active ingredients called levodopa and benserazide. It is not possible for us to predict whether the addition of the plant remedy would reduce your need for the prescription medication.
i would like to know if i can take l dopa drug Madopar
along with mucuna pruriens (not at the same time obviously) but reduce Madopar
to once a day and maybe replace with.
We suggest your doctor read this page and offer the advice since we cannot offer individual suggestions. It is best that your doctor knows that mixing drugs and herbs can have unexpected reactions and as a general rule it is best to learn how the herbs work by themselves before combining, and sometimes lower dosages are required when combining drugs and herbs since herbs can be potent.
Will mucuna pruriens and
Pristiq (desvenlafaxine, an SNRI) have a bad interaction? I know the studies say
do not take with Tricylic antidepressants and MAOI inhibitors but this is an
SNRI (Seratonin-Norepinephrine Reuptake Inhibitor)? Any advice or comments would
A large factor in the interaction between medications and other meds, and with herbal supplements depends on the dosage and the person taking them. I have not seen any studies with this combination so it is not easy to predict. Anytime a person is adding an herb to an existing prescription medication, it is advisable to begin with very low dosages.
I took macuna and also i take anafranil after two days so, i am social phobia patient, i get serious interaction of high BP and insomnia since one months plus anxiety, depression, sinking, worries, please help me to get sleep and out from this conditions. Should avoid use of anafranil, my age is 43 yrs.
Q. I have suffered from a wide range of psychological problems and tried a number of conventional drugs some have worked better then other, none have given a satisfying result, and all have cast side effects. recently I started supplementing with Dr. Ray Sahelian's mucuna extract, witch I have done for 3 weeks now, this has opened a new world for me suddenly I can actually function in the world and live a real life. However Iím wondering whether or not itís a good idea supplementing with mucuna pruriens on a daily basis for a long period of time. Some side effects and even neurotoxicity seams to be associated with synthetic L-dopa. I have also heard that at least synthetic L-dopa loses its effectiveness over time. Iím not sure if this is due to upregulation or some other process of homeostasis. On the other hand some people claim that those side effect only occurs when synthetic L-dopa is taken. And that the natural herb mucuna isnít associated with any of these side effects and that it actually is a safe herb even for long term us. Does the herb mucuna pruriens lose it effect over time? And how different is really natural L-dopa to its chemical counterpart?
A. We don't have much experience in the West with using mucuna pruriens for prolonged periods, so we don't know what the side effects would be when used for months or years without a break. As a general rule, it is a good idea to take a day or two off a week off from a particular herb and then one full week off every month or every other month. By taking these breaks, any potential side effects are either avoided or significantly reduced. The percentage of L-dopa in mucuna pruriens is small, as opposed to taking in pure L-dopa as a pharmaceutical drug. Initial studies indicate mucuna pruriens has brain protecting potential.
Q. The reason i started using macuna pruriens was complex social problems. I maintained a social life only because it was better than having no friends. I avoided people as much as possible for instane I did most of my work from home saying that I liked it that way, but I really didnít. Like most people I have a strong interest for the opposite sex, yet I couldnít build a healthy relationship with a girl. I really didnít feel any thing for the girls I met, as a consequence I felt guilty as if I was conning the girl and not being honest. It always ended up with me braking up. In general I felt a constant discomfort being around others yet I was yearning for contact with other people. Taking mucuna pruriens herb has made me normal I enjoy seeing other people in a new way. If i ever will design a formula for social phobia mucuna pruriens is it! I have tried a number of drugs none has given satisfying results. Yet Iím a bit concerned about side effects naturally I think about the regular Parkinson drugs, synthetic L-dopa for instance, which clearly is serious stuff. How ever, and I donít really understand how, natural L-dopa seams to be vary different from the synthetic variant. How can natural L-dopa be free from neurotoxicity? Is its chemical structure actually different from synthetic L-dopa? I have tried clean natural L-dopa in order to evaluate this I compared mucuna with a dose of natural L-dopa that was corresponding to the quantity of L-dopa I estimated would be in the herb. And I must say that the effect was wary much similar.
A. Mucuna pruriens has only a few percent L dopa, and it has many other compounds in it that have an effect on the brain and body. Many of these compounds have antioxidant abilities. So, mucuna pruriens is not the same as L dopa medication although it may have similar clinical benefits. We have not seen enough human research to know in detail what other brain chemicals a mucuna pruriens supplement would influence.
Q. I am very interested in your product called mucuna
pruriens in 400 mg capsule. In my recent past, I bought a product from a
health food store, it is a homeopathic product, to be used externally to rub
on the skin, usually used by athletes, and in this product, it is a combination
of ingredients, and one of its ingredients consist of mucuna pruriens; the
product was quite effective on me as far as for increasing the natural
substances my body needs, however, there is one effect on me, even though it is
not detrimental to my health, it results in the twitching of my facial skin,
including the twitching of my eyelid, could you possibly tell me why that combo
external product would cause this reaction ? Do you think just the mucuna
pruriens itself would give me the same reaction, or did anyone ever experience the same reaction as I did with that external
combo skin product that I bought? Generally speaking, does mucuna pruriens increase or decrease blood pressure?
I do know different individuals reacts in different ways, that is why I am
asking in a general way among the many users.
A. We have no idea what this product is, and how much of the herbs or nutrients can be absorbed through the skin. We have not had feedback yet from anyone who has reported such a reaction from mucuna pruriens herb. We have not seen any good studies regarding the influence of mucuna pruriens on blood pressure and have not had enough feedback from users as to any significant effect of mucuna pruriens on blood pressure. Much may depend on the dosage that is used. It is often a good idea to start new supplements in low dosages.
Q. Is mucuna pruriens safe to take while breast
A. We have not seen human studies regarding the safety of mucuna pruriens supplement use in women who are pregnant. To be on the safe side, it may be cautious to not use this herb during pregnancy.
Q. Please clarify the difference between the two
mucuna pruriens products below. I am not clear as to what the pecentage of L-Dopa
vis a vis the mg quantity in each product means, and what the difference is,
especially in the net percent of L-Dopa delivered to the brain according to the
Mucuna Pruriens 120 Caps: 100mg of 60%L-Dopa HERBAL POWERS
Mucuna Pruriens 60 caps: 400mg of 10% of L-Dopa Physicians Formula
A. There are a number of extracts of mucuna pruriens and we can't comment on other products form other companies since we have not idea what effect they have. Please keep in mind that there are many active ingredients in mucuna pruriens besides L dopa. Also, a higher dosage or percentage of L dopa is not necessarily better since since effects can occur. The best way to tell what works for you is to try each product separately and see how it works for you. One product may be ideal for one person but cause problems and side effects in another person.
Q. Why is the mucuna puriens product you carry
standardized to 10% l-dopa when other mucuna puriens supplement formulations are
A. There is no research that says one extract potency of mucuna pruriens is better than another extract potency. Historically most herbal preparations have been used as the crude powder rather than the extract form. Until research clearly shows a particular mucuna pruriens extract potency is clinically more effective than another potency, this product will remain at 10 percent L Dopa extract.
Q. I have been diagnosed with Parkinson's disease. I
am 55 in good health otherwise. I ordered Passion RX and received yesterday. I
have read where Mucuna pruriens herb is beneficial to Parkinson patients. Can I
take the two products at the same time or should I only use one or the other?
Passion RX contains Mucuna pruriens herb. I presently take Mirapex 1mg 3 x
daily. Is there a conflict?
A. We suggest you first learn how each product is effecting you by itself since both are potent. We prefer people not combine the two supplements the same day.
Q. I have been using Physicians Formulas mucuna 400
mg 10% L dopa along with carbadopa 25mg tid for Parkinson's Disease and have
been doing better than with the sinemet 100mg/25 mg I previously took. Now the
changed formulation is 200 mg 15% L-dopa. I really hate to go back to fussing
around again to find the proper dosages as this is not easy nor quick. Are there
plans to produce the old formulation still? If not will they produce a
formulation that has an equivalent L dopa dose? (40 mg).
A. Apparently the original source of 10 percent L dopa was no longer available and the formula was switched to 15 % L dopa at 200 mg. Keep in mind that L dopa is not the only active substance in mucuna pruriens and just going by the L dopa percentage does not take full account of the many other substances in mucuna pruriens that influence brain chemistry. There are no plans to return to the old formulation. Also one needs to keep in mind that the dosage requirement of medications and herbs can change over time. The effect of certain herbs can begin to accumulate over time and less of a dosage is required. The only way to know for sure is by trial and error. That different mucuna pruriens supplements on the market, even if the percentage of L dopa is the same, may have different effects due to variations in growing the plants, processing, storing, and encapsulating.
Q. I came upon mucuna pruriens herb being suggested
for Parkinson's disease and was wondering if you know if it would also be
helpful for decreasing the tremors in essential tremor.
A. This is a good question. We don't have any feedback regarding the use of mucuna pruriens herb in the treatment of essential tremor, but if your doctor approves it may be worth trying the herbal extract.
Q. Do you know how much caffeine is in macuna
pruriens herb? The reason I ask is that my Dr. is concerned about my calcium
absorption. Would there be enough caffeine to interfere with calcium absorption
if I take macuna pruriens herb over a long time - many years?
A. We are not aware of caffeine being present in this herb.
Q. I have been diagnosed with Parkinson's Disease or
Parkinsonism. I currently take Carbidopa 10 MG / Levadopa 100MG 4 times per day.
I would like to try Mucuna Pruriens herbal extract and see if I can possibly
reduce my medication. Can you tell me if there is any contraindication?
A. Caution is advised when combining herbal supplements and medications. When adding any supplement to a medication program very low dosages should initially be used. We suggest you ask your doctor to read this page and guide you since we can't give specific individual advice.
I am a home gardener here in Texas, USA. I just
bought Mucana pruriens seeds from a company in Florida, with a 90 day growth
cycle and am waiting for them to pop thru the soil. My husband has Parkinsonís
and takes a drug called carbidopa-levodopa 4 times a day that replaces his lost
natural dopamine. If I get a harvest from the bean plants, can he just eat the
raw bean for the same effect as your 200mg capsules?
There are many factors that influence the composition of a bean, the soil, temperature, how it is grown, etc. It is not possible for us to know whether consuming the bean would be effective and what the l dopa content would be. The capsules have a 15 % l dopa concentration that is standardized.