Enzymatic Therapy -
Petadolex, 60 Softgels
Petadolex contains the patented extract of butterbur that supports healthy
blood vessel tone in the brain, as well as normal blood flow in the
brain.* It has been the subject of two placebo-controlled clinical
studies. In the most recent, participants reported a 62% improvement."
Petadolex is standardized to contain 15% of butterbur's key ingredient, petasin. It's also guaranteed to be pyrrolizidine alkaloid (PA) free, so you can use it with confidence. PA's are toxic compounds that can harm the liver. Studies demonstrate patented Petadolex is safe and well tolerated.
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Petasites
Supplement Facts:
Purple Butterbur (Petasites hybridus) -
50 mg*
(Petadolex brand) Root Extract
standardized to contain 7.5 mg petasins and to be free of pyrrolizidine alkaloids (PAs)
Recommendations: One petasites softgel three times daily,
or 2 softgels 2 times daily
for the first few weeks. Thereafter, one softgel twice daily. However,
these are rough guidelines since each person is unique in their response.
* Petasites daily value not established
Active ingredients in Petasites
Petasin, a kind of sesquiterpene ester, appears to be a major active compound of
petasites hybridus extract. It has inhibitory activities on leukotriene generation in
eosinophils and neutrophils. This indicates that it may have anti-inflammatory and
anti-allergy properties. Petasites may be helpful for seasonal allergic rhinitis.
Petasites also helps reduce smooth muscle spasm.
Medical uses for Petasites
Migraine Headache: Two clinical studies using 50 mg and 75 mg of a standardized
Petasites extract twice daily for 12 weeks demonstrated its effectiveness as a
prophylactic treatment for migraines. When used to treat migraines, administration is
prophylactic and supplementation should be carried out daily for a few weeks and then
tapered until migraine incidence begins to increase. Petasites may work by preventing
peptidoleukotriene biosynthesis.
Butterbur root extract and music therapy in the
prevention of childhood migraine: An explorative study.
Eur J Pain. 2007 Jul 27; Department of Child and Adolescent Psychiatry,
University of Heidelberg, Blumenstrasse 8, D-69115 Heidelberg, Germany.
This study was to assess efficacy of a butterbur root extract Petadolex and
music therapy in primary school children with migraine.Following a 8-week
baseline patients were randomized and received either Petadolex butterbur root
extract, music therapy or placebo over 12 weeks. Butterbur root extract and
music therapy might be superior to placebo and may represent promising treatment
approaches in the prophylaxis of pediatric migraine.
Asthma/Bronchitis: Various parts of the petasites plant have
been used for centuries to treat bronchial asthma and whooping cough. Petasites
possible effectiveness in treating respiratory disorders such as asthma and bronchitis is
attributed to the antispasmodic and anti-inflammatory properties of the petasin
constituent. (see below)
Gastrointestinal Disorders: A German study found extracts of
petasites blocked ethanol-induced gastric damage and reduced ulcerations of the small
intestine caused by indomethacin, an anti-inflammatory drug used to treat arthritic
conditions. The results of this study were attributed to inhibition of lipoxygenase
activity and leukotriene biosynthesis.
Enzymatic Therapy -
Petadolex, 60 Softgels