Resveratrol pill benefit - High Content in Red Wine
Resveratrol (3,4',5-trihydroxystilbene) is found in various plants, including
grapes, berries and peanuts. It is also present in wines, especially red wines.
Resveratrol is produced naturally by grapes to fight off fungal diseases that
can take hold when it's damp outside. The amount of resveratrol in wine varies
widely, depending on the type of grape, where it's grown, and how it's
processed. For example, since resveratrol is found primarily on grape skins, it
is almost nonexistent in most white wines, which are fermented only after the
skins are removed.
Will you live longer if you take a resveratrol pill? It will take
many years for scientists to find out. The answers are not yet available.
Resveratrol 10 mg, Club Natural,
Developed by Ray Sahelian, M.D.
Resveratrol
( trans-3,5,4'-trihydroxystilbene ) is a protective compound produced by grapes and other plants in response to
environmental stresses. Studies have demonstrated that resveratrol has potent
antioxidant activity and also has the ability to inhibit platelet aggregation.
These actions may help prevent free radical damage throughout the body and
provide protective support to the cardiovascular system.
Red wine has about 1.5 to 3
milligrams of resveratrol per liter (a liter is almost 34 ounces).
Resveratrol 10 mg - for the certificate of analysis of this resveratrol product,
click the link below in blue
Click here to learn more about Resveratrol pill
Supplement facts
Resveratrol 10 mg - extract from Hy Zhang Root Extract (Polygonum
cuspidatum)
Suggested Use: One resveratrol capsule with
breakfast a few
times a week.
Resveratrol natural molecule activates a cell's survival defense
enzyme, which prolongs the time cells have to repair their broken DNA. It is not
surprising that extensive research from all over the globe indicates that resveratrol has a wide range of beneficial properties. It is anti-inflammatory,
antioxidant, anti-infective, and it activates the longevity gene. It's use is
even attributed to the curing of serious health conditions. As red wine is a
rich source of this amazing substance, many sources will reference resveratrol
as "red wine molecules," "red wine polyphenols," "red-wine extract," etc.
Unfortunately, there is a great deal of misinformation about resveratrol, so you
need to keep the following in mind when reviewing articles and marketing
information about related products. As resveratrol is found in the skins of
grapes, red wine will provide several times more resveratrol than white wine. Grape
skins are not used in the production of white wine. As resveratrol is produced
within the grape skin in response to attack by specific molds, grapes and wine
produced in moist, northern climates (where these fungi are more prevalent)
yield more resveratrol. As resveratrol is vulnerable to fairly rapid
destruction by light and oxygen, the fact that wine is stored in air-tight, cool
conditions away from sun light protects the resveratrol content. Only
immediately after a bottle of wine is opened is the maximum resveratrol potency
available. Since wine also involves the
potential damage from alcohol and preservatives, many people prefer a dietary
supplement source for resveratrol.
Red wine and
Resveratrol
Red wine made from Pinot noir, Merlot, and Zweigeltrebe grapes all have a high
resveratrol content. In a study of hundreds
of wines from around the globe, Cornell researcher Leroy Creasy found the
highest resveratrol levels in pinot noir grapes grown in cooler, rainy places
like the Finger Lakes region of upstate New York and Oregon's Willamette Valley.
(In fact, the highest resveratrol content found in a wine was in Vinifera's
Fleur de Pinot Noir, with four times as much as the nearest California pinot
noir tested). Long sown in France's cool Burgundy region, pinot noir is
considered a finicky grape to grow, in part because it is susceptible to rot,
which may be the reason it produces more resveratrol than other grapes--up to 40
times as much resveratrol as grapes such as merlot and cabernet sauvignon.
Diagnostic performance of urinary
resveratrol metabolites as a biomarker of moderate wine consumption.
Clin Chem. 2006 Jul;52(7):1373-80. Nutrition and Food Science Department-CeRTA,
Pharmacy School, Hospital Clinic, Institut d'Investigacio Biomedica August Pi i
Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
We evaluated resveratrol metabolites, potential biomarkers of wine
consumption, in humans after moderate consumption of sparkling, white, or red
wines. We performed 2 randomized, crossover trials and a cohort study. In the
first study, 10 healthy men consumed 30 g of ethanol/day as sparkling wine or
gin for 28 days. In the second trial, 10 healthy women consumed 20 g of
ethanol/day as white or red wine for 28 days. We also evaluated 52 participants
in a study on the effects of a Mediterranean diet on primary prevention of
cardiovascular disease (the PREDIMED Study). We used liquid
chromatography-tandem mass spectrometry to analyze urinary total resveratrol
metabolites. RESULTS: We observed significant increases in urinary total
resveratrol metabolites [72.4, 48.5-96.2, 211.5] after consumption of sparkling,
white, or red wine, respectively, but no changes after the washout or gin
periods. In the cohort study, the reported daily dose of wine consumption
correlated directly with urinary total resveratrol metabolites. Resveratrol
metabolites in urine may be useful biomarkers of wine intake in epidemiologic
and intervention studies.
Resveratrol Benefit
for Alcohol Abuse
Effect of resveratrol on alcohol induced mortality and liver lesions in mice.
BMC Gastroenterol. 2006 Nov 14;6(1):35
Resveratrol is a polyphenol with important antiinflammatory and antioxidant
properties. We investigated the effect of resveratrol on alcohol induced
mortality and liver lesions in mice. Mice were randomly distributed into four
groups (control, resveratrol-treated control, alcohol and resveratrol-treated
alcohol). Chronic alcohol intoxication was induced by progressively
administering alcohol in drinking water up to 40% v/v. The mice administered
resveratrol received 10 mg/l in drinking water. The animals had free access to
standard diet. Blood levels were determined for transaminases and IL-1. A
histological evaluation was made of liver damage, and survival among the animals
was recorded. Transaminase concentration was significantly higher in
the alcohol group than in the rest of groups. IL-1 levels were significantly
reduced in the alcohol plus resveratrol group compared with the alcohol group.
Histologically, the liver lesions were more severe in the alcohol group, though
no significant differences between groups were observed. Mortality in the
alcohol group was 78% in the seventh week, versus 22% in the alcohol plus
resveratrol group. All mice in the alcohol group died before the ninth
week. CONCLUSIONS: Resveratrol reduce the mortality and liver damage associated
with alcohol abuse.
Resveratrol and
muscle tissue
Cellular effects of resveratrol in skeletal muscle.
Life Sci. 2009 Feb 19. Naylor AJ. School of Pharmacy, Wingate University,
316 N. Main Street, Wingate, NC 28174.
Resveratrol is a stilbene found naturally in various plants with the highest
concentration in the skin of grapes and peanuts. The function of this compound
in plants is to confer resistance against bacterial and fungal infection. The
effects of resveratrol in animals and humans are currently an area of intense
investigation. Resveratrol has been shown to have a plethora of health benefits
including protection against cardiovascular disease, various cancers, type II
diabetes, and also has life extending properties. The beneficial effects of
resveratrol in skeletal muscle have been given less attention in the literature
compared to other tissues. Therefore, the focus of this review is to highlight
the cellular effects of resveratrol in skeletal muscle. Resveratrol has been
shown to alter protein catabolism and muscle function, and confer resistance
against oxidative stress, injury, and cell death of skeletal muscle cells.
Resveratrol and
prostate cancer
Resveratrol, an antioxidant found in wine, grapes and berries, can slow the
growth of prostate tumors in mice.
Resveratrol product
questions
Q. How much resveratrol is in Pinot Noir?
A. The resveratrol content in red wine varies on the vintage. We
will look for any research on the amount of resveratrol in Pinot Noir red wine.
Q. Does rainfall or climate influence
resveratrol content in red wine?
A. Rainfall during fruit development results in higher amounts of
resveratrol in berry skin, whereas resveratrol synthesis and accumulation in
grape seeds are not related to climate change.
Q. Is the amount of resveratrol different
in seeded grape or seedless grape?
A. There is more resveratrol in skin in seeded cultivars than in
seedless ones, in both berry skin and seeds in winemaking grapes than in table
grapes, and in red grapes than in green ones.
Q. Very informative site; I read on a
web site re Resveratrol: Identification of a p53-dependent pathway in the
induction of apoptosis of human breast cancer cells by the natural product,
resveratrol. Resveratrol, Conclusions: We therefore conclude that the natural
product, resveratrol, *induces apoptosis* in breast cancer cells via
p53-dependent pathways. Then read several that support the fact that it appears
to cause apoptosis in breast and other cancers, but several research papers on
http://www.ncbi.nlm.nih.gov or www.pubmed.com state resveratrol is an agonist or
superagonist for breast cancer, and simulates the proliferation of breast cancer
cells like estradiol E2. One research paper said tests saying it causes
apoptosis uses rat/mice cells and ones saying it as an agonist used human breast
cancer cells. Can you please look into this and comment? Being a lay person, I
may have misunderstood (although I don't think so) and your comments would be
most appreciated since this if true would limit the usefulness of resveratrol in
dosages that are beneficial to cardio etc. Are there similar resveratrol egative
effects for men, since it might also exacerbate other cancers? Here are some
reseveratrol references I found and short extracts (there are many more
references searching for Resveratrol cancer, or with breast cancer and
diethylstilbestrol: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=28446
In some cell types (e.g., MCF-7 cells), resveratrol functioned as a superagonist
(i.e., produced a greater maximal transcriptional response than estradiol)
whereas in others it produced activation equal to or less than that of estradiol.
Resveratrol also increased the expression of native estrogen-regulated genes,
and *it stimulated the proliferation
of estrogen-dependent T47D breast cancer cells*. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12594813&dopt=Abstract
Resveratrol acts as an estrogen receptor (ER) agonist in breast cancer cells
stably transfected with ER alpha.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=12421874
As a preliminary step toward elucidating rapid phytoestrogen action on breast
cancer cells, we investigated the effect of 17-beta estradiol (E2), genistein,
daidzein and resveratrol on the activation status of signaling proteins that
regulate cell survival and invasion, the cell properties underlying breast
cancer progression. The effect of these estrogenic compounds on the activation,
via phosphorylation, of Akt/protein kinase B (Akt) and focal adhesion kinase (FAK)
were analyzed in ER-positive and -negative human breast cancer cell lines. E2,
genistein and daidzein increased whereas resveratrol decreased both Akt and FAK
phosphorylation in nonmetastatic ER-positive T47D cells. In metastatic
ER-negative MDA-MB-231 cells, all estrogenic compounds tested increased Akt and
FAK phosphorylation.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=28446In some cell
types (e.g., MCF-7 cells), resveratrol functioned as a superagonist (i.e.,
produced a greater maximal transcriptional response than estradiol) whereas in
others it produced activation equal to or less than that of estradiol.
Resveratrol also increased the expression of native estrogen-regulated genes,
and *it stimulated the proliferation of estrogen-dependent T47D breast cancer
cells*.
A. Sometimes it is easy to lose focus when reviewing detailed
laboratory studies in vitro. So much depends on the dose of resveratrol used and
the skills of the researchers and their primary focus. Different resveratrol
doses may have a different affect on estrogen receptors or breast cancer. The
most important study is what happens when animals or humans take resveratrol on
different dosages. So far only one long term animal study is available which
showed increased lifespan. See
resveratrol for more
info.
Q. What is the benefit in what
reservatrol does. What is the safety of resveratrol with cancer although it also
has other potential benefits. If I buy a reservatrol product, how can I know it
is the right dose for a man or a woman without exacerbating cancer or breast
cancer or its onset.
A. There are many questions that are not answered about resveratrol
use since human studies are lacking. We understand people want answers about
supplements they are taking or plan to take but without human research no clear
answers can be given about the benefit or side effect of resveratrol.
Have you heard the
hype about resveratrol supplements helping mice live longer? It seems this
red wine ingredient is now the rage and consumers are flocking to vitamin
stores or on the internet to buy a resveratrol supplement. Before you rush
to make a purchase, do yourself a favor by getting a balanced viewpoint on
this topic.
What is Resveratrol?
Resveratrol is a protective compound produced by grapes, berries, and other
plants in response to environmental stresses. A high concentration of
resveratrol is found in red wine, particularly Pinot Noir.
The Resveratrol Hype
What made resveratrol popular was a November 2006 study
published by
Harvard University researchers in
Boston that reported mice lived longer
when given a resveratrol supplement. The news media
caught up with titles such as , "Resveratrol improves health and survival of
mice on a high-calorie diet.”
How Much resveratrol is
there in red wine?
Red wine has about 1.5 to 3 milligrams of resveratrol per liter (a liter is
almost 34 ounces).
Benefits of Resveratrol
Resveratrol has potent antioxidant activity and also has the ability to inhibit
platelet aggregation thus making the blood less likely to clot. In addition, it
has anti-inflammatory, anti-tumor, and anti-infective properties. Resveratrol
may even by helpful in preventing neuronal damage in Alzheimer’s disease.
Resveratrol and
Longevity
Harvard researchers tested resveratrol on middle aged mice. Resveratrol
supplementation increased their survival. In previous studies over the past few
years, resveratrol was found to have a similar longevity benefit on yeast, flies
and worms. This was the first evaluation of resveratrol on survival extension in
mammals. One group of mice ate a normal diet. The second was fed a high-calorie
diet and the third had the same high calorie diet but was given resveratrol
supplements. By the time the mice were 114 weeks old, about 60 percent in the
high-calorie group had died, compared to about 40 percent in the low calorie
diet group and the group with the high calorie diet supplemented with
resveratrol. The mice taking resveratrol had healthier heart and liver tissue,
decreased blood sugar levels, better insulin sensitivity and were more active
than the other rodents.
Resveratrol and Cancer
Recent laboratory studies indicate that resveratrol has potential in various
cancers, including breast, prostate, and neuroblastoma.
Resveratrol Side Effects
Since human studies with resveratrol are not available, we don’t know the long
term side effects of daily use.
Availability and Dosage
Much of the resveratrol sold in supplement form is from the herb
Polygonum cuspidatum. The most common dosage is 10 mg of resveratrol per capsule
or tablet. It is not clear at this time the ideal dosage of resveratrol to take on a daily
basis and how it would interact with other supplements or medicines. I can only
tell you that I plan to take one 10 mg capsule once or twice a week until more
research is available, and I also plan to drink one or two ounces of red wine
most evenings with dinner.
Resveratrol and
prostate cancer
Wine lovers are probably already aware that red wine contains a powerful
antioxidant: resveratrol. Animal studies hint that it can help prevent weight
gain and developing the symptoms of diabetes and obesity. But the health
benefits of this antioxidant don’t end there. Researchers at the University of
Alabama at Birmingham's Department of Pharmacology and Toxicology gave male
mice, on a daily basis, the equivalent of resveratrol found in a bottle of red
wine. They discovered that the mice were significantly less likely to develop
prostate cancer. Those mice that consumed resveratrol but still got cancer
developed less serious tumors. Red wine has about two to three milligrams of
resveratrol per liter (a liter is almost 34 ounces). But since wine can have
negative effects on some hormone-related cancers, taking resveratrol in
supplement form is a good idea. Most resveratrol supplements on the market have
about 10 mg per capsule. Taking one or two resveratrol supplements a week is
fine if you are consuming many other antioxidants on a daily basis. However, if
you hardly take any antioxidant supplements, you can take the resveratrol more
frequently. You can find resveratrol supplements in most health food stores.
Resveratrol and
breast cancer
I animal studies, resveratrol has been found to help prevent prostate
cancer. This powerful antioxidant has a whole host of potential health benefits
and we all look forward to human research over the next few years to tell us the
potential benefits of this fascinating substance. Now, women have a specific
reason to pay attention to this potential anti-aging supplement: It may help
protect against breast cancer. Researchers at the University of Alabama at
Birmingham's Department of Pharmacology and Toxicology found that female mice
given resveratrol had a significantly reduced risk of developing breast cancer.
Blueberries, red grapes, cranberries, bilberries, and - of course - red wine are
all good sources of resveratrol. You can also find it in supplement form in many
health food stores.
Resveratrol questions
Q. I read an article in Time magazine about resveratrol. The article mentions
the benefits of resveratrol with studies done using mice. But one researcher
(don't have his name right off), who acknowledges the potential benefits of
resveratrol, claims that resveratrol supplements are not the answer because he
says there not well absorbed by the body. If so, how did they get the
resveratrol into the blood of the mice and rats done in the studies? Then how
would you absorb it from grapes if you eat them? In the article he talked about
coming up with a special form of resveratrol that is well absorbed by the body,
but this may just be an opportunity for him to make some money. Then he would
patent the resveratrol product or even sell it as a drug.
A. Yes, one cannot trust that researchers will be completely
honest, after all they are spending a lot of money and time on a project and
they don't want other people to make money from their efforts. It is
understandable, most of us would feel that way. You may consider Dr. Sahelian's
opinion on resveratrol which he discussed in his Novermber issue of his
supplement newsletter
2006.
Q. Someone says that resveratrol to
be effective it must enter the bloodstream but taken orally it metabolises too
quickly so rendering it useless. Is that true?.
A. There have hardly been any studies with resveratrol supplement
use in humans and determination of absorption and metabolism. However, studies
with resveratrol and wine consumption shows the resveratrol in wine is absorbed
easily and then metabolized to other substances. We don't have a clear
understanding at this time how long resveratrol stays in the body before it is
altered. There are many questions about resveratrol supplement use that are not
clearly understood at this time.
Q. I took the Club Natural
resveratrol for a few days in a row and noticed my nose clearing up and
breathing easier.
Q. Because I value Physician
Formulas products and would prefer to purchase from PF, whom I trust, I would
like to ask that you increase the strength of your resveratrol so that it aligns
with that manufactured by Longevinex, Jarrow, and Natures Way. Animal studies
have shown that a human would have to ingest approximately three to five grams
per day (150 kg male) to achieve doses similar to those ingested in test animals
for optimal results. Athletes are experimenting with much larger doses. None of
this is practical with an absurd 10mg capsule.
A. At this time pure resveratrol is not available over the counter,
it is derived as an extract from an herb. When taking a resveratrol supplement,
one is also ingesting a number of other compounds. If high dosages of the
resveratrol supplement is taken, there could be side effects of excessive
alertness and sleep deprivation which would counteract any benefit from the
resveratrol. Even if pure resveratrol is available, no one knows the ideal
dosage. Sometimes too much of a good thing can be harmful. Just because a
supplement is helpful at a certain dosage in animals does not necessarily mean
humans would benefit from the dose. The opposite could happen. The whole issue
is much more complicated than just converting the dosage in rodents by weight to
that of human.
Q. How do resveratrol pills fair out with regards to
type II diabetes? I also have issues with vitamin B deficiency, which I think is
part of diabetes. Fatigue, stress, weight loss are all in the same category. In
which I suffer from all of the above! Will resveratrol help? Based on what I'm
reading i'm not entirely sure.
A. Resveratrol pill supplements have not been studied in humans as
a treatment for stress, diabetes or fatigue.
Can I take eyesight with daily dose of resveratrol
250 mg? I also take phosphotydle serene 100mg daily.
Eyesight Rx is used every other day and other supplements can
be taken on the days off.
Can you tell me whether it would be detrimental for
someone with a long blood clotting time to take resveratrol? I ask this because
I've read that it can prohibit platelet aggregation.
It's difficult to say since human studies are not available
and there are many types of resveratrol products on the market with different
potencies. But, as a general rule, it is likely that resveratrol products have
blood thinning potential.
Supplements and Herbs tongkat ali net
Cost of resveratrol extract in
2008
Resveratrol (Polygonum Cuspidatum or Hu Zhang) 20% (min 1kg) $85/kg
Resveratrol (Polygonum Cuspidatum or Hu Zhang) 50% (min 1kg) $160/kg
In 1997, Source Naturals was the first national
vitamin company to introduce this amazing compound to America. Today we
continues leadership in the Wellness Revolution, offering consumers a wide range
of advanced resveratrol supplements. Source Naturals now introduces a high
potency 200 mg Resveratrol as a new addition to the widest selection of
Resveratrol available.
Resveratrol 200 tablets
For Heart and Healthy Aging
Source Naturals Resveratrol 200 contains 200 mg of pure resveratrol, a compound
produced by grapes and other plants for protection from environmental stresses.
Recent studies have demonstrated that resveratrol activates SIRT I genes, which
mimic the healthy aging benefits of caloric restriction. Resveratrol may support
heart health by providing the antioxidant protection needed for healthy
circulation, and by inhibiting inflammation messengers including NF kappa B.
Polygonum cuspidatum Root Extract Standardized to 50% Natural trans-Resveratrols
Yielding:
400 mg
Natural trans-Resveratrols 200 mg
Red Wine Extract 10 mg
Other Ingredients: dibasic calcium phosphate, silicified microcrystalline
cellulose, stearic acid, modified cellulose gum, and colloidal silicon dioxide.
Suggested Use: 1 tablet daily.
Warning: If you are taking anti-coagulant medications or any prescription
drugs consult your physician before use. Not for use by women who are pregnant,
may become pregnant, or breastfeeding. Do not use this product if you have or
develop abdominal pain, watery or increased stools, or diarrhea.
SN2292 30 tabs • SN2293 60 tabs • SN2294 120 tabs
Emails
I am Morris Luo, the sales manager of Shanghai DND Pharm. I get your information
from your website by searching Resveratrol and other extracts. We are herbal
extract manufacture and supplier. I contact you to check whether we can
establish business relationsip in future. Here I give a brief introduction of
our company:
DND Pharm is Phytochemical manufacture with the background of Phamraceutical
Area for more than 10 years. We are a stock company with 3 company with
Pharmaceutical back ground: zhejiang dnd pharm is mainly produce finnal drugs
and some plant extract; Sichuan dnd pharm is professional in plant extract; and
DND Chemical produce API's. The are all GMP certified. In Zhejiang,Sichuan and
Jiangsu, we own GAP plantation of Ginkgo biloba, Tripterygium wilfordii, Liriope,
Bupleurum and so on. We mainly product the following product:
1) Resveratrol, 50%, 98% HPLC
2) Apple Extract, apple polyphenols 75%, phloridzin 8%, chlorogenic acid 15%,
HPLC& UV
3) Huperzine A, 98%, 1% , HPLC
4) Natural Lycopene, 10%CWS, HPLC
5) Natural Beta carotene, 10% CWS, HPLC
6) Green tea extract, UV
8) Grade seed extract, OPC95% UV
9) Ginkgo Biloba Extract, 24%/6% HPLC
10) Rhodiola extract, salidroside 3% HPLC
11) Bilberry extract, anthocyanidin 25, HPLC&UV
12) Ginseng extract, ginsenoside 10% UV
13) Schizandra extract, total schizandrins 9% HPLC
14) St John's Wort Extract, Hypericin 0.3% UV
and so on. We also supply the OEM of Health Food. If you need more information
about our product, please send me email. I will give you reply as soon as
possible. Expecting to cooperate with you in future of herbs extract. Morris Luo
Sales Manager Shanghai DND Pharm-Technology Co., Inc.