Rosavin health benefit
Rosavin is a substance found in rhodiola species.
Phytochemical and analytical studies of extracts from
Rhodiola rosea and Rhodiola quadrifida.
Pharmazie. 2007 Apr;
Column chromatography of hydrophiic extracts from Rhodiola rosea and Rodiola
quadrifida led to the isolation of cinnamic alcohol, chlorogenic acid,
rhodiooctanoside, rosiridin,
rosavin and the phenolic compounds salidroside, rhodiolin and a novel compound
consisting of viridoside with an attached arabinose unit (mongrhoside).
Evaluation of biologically active compounds in roots
and rhizomes of Rhodiola rosea L. cultivated in Lithuania.
Medicina (Kaunas). 2007; Kucinskaite A, Pobłocka-Olech L, Krauze-Baranowska M,
Sznitowska M, Savickas A, Briedis V. Kucinskaite A, Pobłocka-Olech L,
Krauze-Baranowska M, Sznitowska M, Savickas A, Briedis V. Department of
Pharmaceutical Technology and Social Pharmacy, Kaunas University of Medicine, A.
Mickeviciaus 9, Kaunas, Lithuania.
Salidroside
and rosavins (rosavin, rosarin, and rosin), biologically active compounds of
Rhodiola rosea L., were analyzed in dried roots and rhizomes of the plants
cultivated in Lithuania and naturally growing in Altai geographical region in
Russian Federation. Similar amounts of salidroside were found in the extracts
(1.35-1.62 mg/mL), irrespective of the origin of the crude plant; however, the
differences in the profile of rosavins were substantial with higher content of
total rosavins in the extracts obtained from the plant cultivated in Lithuania
(7 vs. 4 mg/mL). It was demonstrated that extracts prepared with 70% (v/v)
ethanol contained low concentration of salidroside (0.16-0.17 mg/mL), while the
extraction of rosavins with 70% (v/v) ethanol was more efficient compared to 40%
(v/v) ethanol.
Adaptogenic and central nervous system effects of
single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice.
Phytother Res. 2007 Jan; Perfumi M, Mattioli L. Department of Experimental
Medicine and Public Health, University of Camerino, Via Scalzino 3, 62032
Camerino (MC), Italy.
Rhodiola rosea L., or 'golden root', is a popular plant in traditional medicine
in Eastern Europe and Asia, with a reputation for improving depression,
enhancing work performance, eliminating fatigue and treating symptoms of
asthenia subsequent to intense physical and psychological stress. Due to these
therapeutic properties, R. rosea is considered to be one of the most active
adaptogenic drugs. To confirm and extend results obtained in the few preclinical
and clinical studies available in English language journals, the purpose of the
present study was to re-investigate the effects produced by a single oral
administration of an R. rosea hydroalcohol extract (containing 3% rosavin and 1%
salidroside) on the central nervous system in mice. Our results show that this
R. rosea extract significantly, but not dose-dependently, induced
antidepressant-like, adaptogenic, anxiolytic-like and stimulating effects in
mice.