Tribulus Extract product

Tribulus terrestris, also called "puncture vine" is a plant long used around the world for the treatment of various ailments. Tribulus extract is popularly claimed to improve sexual function in humans. In Turkey, tribulus is commonly used in folk medicine for the treatment of abdominal colic, hypertension and high cholesterol. In Europe tribulus has been used in folk medicine throughout history, as far back as the Greeks, treating such wide-ranging conditions as headache, nervous disorders, constipation, and sexual dysfunction. In China and India, tribulus has been touted for use in liver, kidney, urinary, and cardiovascular remedies. Additional sexual herbs and supplements include Horny-Goat-Weed herbal extract and Deer-Antler-Velvet. For information on natural ways to treat impotence.

Tribulus extract, physician formulated

Tribulus is a tropical vine common in sandy soil throughout India, Pakistan, and Sri Lanka. Tribulus contains furostanol saponins, the active component. This herb is popular for its potent role in supporting reproductive function. Tribulus terrestris can be used by both men and women.

Tribulus extract Supplement Facts
Tribulus extract -- 400 mg
     (standardized to 40 % saponins)

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Sxual herbs that are effective in improving stamina and performance
Additional herbs that have an influence on sexuality include: Ashwagandha herb, Catuaba herb, cnidium monnieri, coleus forskohlii, Horny-Goat-Weed herb, Maca herb, Mucuna-Pruriens herb, Muira-Puama herb, Rehmannia herb, Rhodiola herb, Tongkat-Ali herb, and Yohimbe.

Where is Tribulus found?
Tribulus terrestris grows naturally in many parts of the world including the Americas, Australia, Europe, the Middle East, and Africa. Tribulus terrestris is considered a noxious weed found abundantly on roadsides and vacant lots whose seeds are sharp and painful to step on. The foliage of tribulus terrestris is toxic to livestock, especially sheep, when consumed in large quantities. The fruits/berries of tribulus are the parts most often used in traditional medicine. The composition of different substances within tribulus terrestris is likely to vary depending on which part of the world it grows.

Tribulus extract Mechanism of Action
Tribulus extract may work by relaxing smooth muscles and increasing blood flow into the corpus cavernosa. The relaxant effect observed is probably due to the increase in the release of nitric oxide from the endothelium and nerve endings. Since tribulus relaxes smooth muscles, this may account for its benefits in abdominal colic.

What's in Tribulus Terrestris?
The fruits of tribulus contain a number of different substances including saponins, glycosides, flavonoids, alkaloids, resins, tannins, sugars, sterols, and essential oil. Recently, two new saponins have been isolated from tribulus terrestris: Terrestrinins A and B, .
   A frequently mentioned substance in tribulus is protodioscin, which some claim is one of the active substances within this plant. When different samples of tribulus were analyzed, significant differences in the composition of saponins were observed depending on the origin and plant part used. One analysis of products showed considerable variations of 0.17 to 6.5 % in protodioscin content.

Availability of Tribulus Terrestris
Tribulus extract is most often found in combination with other sex-enhancing herbs. Tribulus is also sold by itself often in a dosage ranging from 250 to 750 mg. Tribulus is found in a variety of extract potencies. Gokshura is the Ayurvedic herb name for tribulus.

Tribulus extract Cautions and Side Effects
No significant side effects have yet been reported in the medical literature regarding the use of tribulus terrestris. However, little is known about the long-term use of tribulus consumption in humans. As with most herbs, it is best to take breaks from use.

Q. Does tribulus have a side effect of blood pressure increase? I have mild hypertension.
   A. We have not seen human studies with tribulus supplements to know for certain whether or not it influences blood pressure. You may consider at first using half a capsule or a capsule every other day and monitor it. We have not had any reports of high blood pressure side effect from the use of tribulus supplements, but we can't be certain without knowing the results of scientific studies.

Hepatic Effect of Tribulus extract
Tribulusamide A and B, new hepatoprotective lignanamides from the fruits of Tribulus terrestris: indications of cytoprotective activity in murine hepatocyte culture.
Planta Med. 1998 Oct;64(7):628-31. Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Japan.
Tribulusamides A (1) and B (2), new lignanamides embracing two cinnamic amide parts joined in a cis configuration, were isolated from the fruits of Tribulus terrestris, together with four known compounds, N-trans-feruloyltyramine (3), terrestriamide (4), N-trans-coumaroyltyramine (5), and beta-sitosterol. The structures were elucidated by 2D-NMR spectroscopy. Addition of compounds 1-5, especially 1 and 2, to primary cultured mouse hepatocytes significantly prevented cell death induced by D-galactosamine (D-GalN)/tumor necrosis factor alpha (TNF-alpha).

Tribulus and Oxalate
Effect of Tribulus terrestris on oxalate metabolism in rats.
J Ethnopharmacol. 1994 Oct;44(2):61-6. Department of Biochemistry, Panjab University, Chandigarh, India.
This study concerns the effect of an aqueous extract of Tribulus terrestris on the metabolism of oxalate in male rats fed sodium glycolate. Glycolate feeding resulted in hyperoxaluria as well as increased activities of oxalate synthesizing enzymes of the liver i.e. glycolate oxidase (GAO), glycolate dehydrogenase (GAD) and lactate dehydrogenase (LDH), and decreased kidney LDH activity. T. terrestris administration to sodium glycolate fed rats produced a significant decrease in urinary oxalate excretion, and a significant increase in urinary glyoxylate excretion, as compared to sodium glycolate fed animals.

Tribulus and Kidney
Activity of certain fractions of Tribulus terrestris fruits against experimentally induced urolithiasis in rats.
Indian J Exp Biol. 1994 Aug;32(8):548-52. Division of Pharmacology, Central Drug Research Institute, Lucknow, India.
An ethanolic extract of the fruits of T. terrestris showed significant dose dependent protection against uroliths induced by glass bead implantation in albino rats. On subsequent fractionation of the ethanol extract, maximum activity was localised in the 10% aqueous methanol fraction. It provided significant protection against deposition of calculogenic material around the glass bead. It also protected leucocytosis and elevation in serum urea levels. Further, fractionation lead to decreased activity. This could be either due to loss of active compounds during fractionation, or the antiurolithiatic activity of T. terrestris being a combined effect of several constituents present in the methanolic fraction.

Tribulus extract questions
Q. I have seen a number of tribulus extract products on the market. How do I know which extract concentration is best?
   A. You are right that there are a number of different tribulus extract potencies. Human studies have not been done comparing different extract strengths to see which is best for erectile function. Your best option at this time is to try different tribulus extract products to see which one works best for you.

Q. i am a male 30 years old. i was treated for 5 weeks by dompridone 10mg 3 times per day and nizatidine 150 mg twice daily ( as a treatment of gastric reflux) after which i had a low or zero libido and a very weak morning erection. Both drugs can cause hyper prolactinemia and anti androgenic effect. I thought that it may be a hyperprolactinemia but it was not i had a normal LH - PRL - Testosteron - Free Testosteron. Dompridone as a dopaminergic blocker can cause low libido state and nizatidine h2 receptor blocker has anti androgenic effect. i stopped these drugs one year ago but believe me no improvement in morning erection and no improvement in libido at all. i consult many andrologists and endocrinologists and no explanation now I am on tribulus 250 mg cap 3 times daily. What is proper dose of tribulus supplement.
   A. Tribulus comes in varied extract concentrations, therefore not knowing the actual extract potency is difficult for us to say. If it is plain tribulus powder and not concentrated, a dose of 500 to 1000 mg a day is okay to take, and it does not have to be tapered before stopping.

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