Ferula Hermonis - Zallouh information -

An intriguing study in male rats showed that ferula hermonis, when given one time, enhanced sexual activity, and also raised blood levels of testosterone. However, when ferula hermonis was given daily for 10 days, it actually reduced sexual activity, and also reduced testosterone levels. The crude oil from ferula hermonis can enhance erectile function in rodents, however ferula hermonis becomes toxic if used for a long period of time in high doses. In mice, the ingestion of 3 mg/kg of aqueous extract of ferula hermonis for six weeks inhibited social aggression. Body weight and other sex accessory organ weights were significantly reduced. The ingestion of high doses of ferula hermonis by male mice resulted in a significant reduction of their fertility.

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Evaluation of ferula hermonis
At this point it is difficult to make any firm recommendations regarding the use of ferula hermonis. Occasional use appears to be safe, but long term use is discouraged until more is known whether or not zallouh is toxic with chronic use.

What's in Ferula hermonis herb?
Ferula hermonis extract has ferutinin, teferin and teferdin.

Ferula hermonis research on sexuality
Role of ferutinin in the impairment of female sexual function induced by Ferula hermonis.
Physiol Behav. 2006 Dec 30;89(5):656-61. Department of Biomedical Sciences, Section of Pharmacology, and National InterUniversity Consortium for the Study of Natural Active Principles (CINSPAN), University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy.
In the present study, we evaluated the effects of single components of Ferula hermonis extract on female rat sexual behaviour. Ovariectomized rats hormonally primed with estradiol benzoate (1.5 or 10 microg/rat s.c.) and progesterone (500 microg/rat s.c.) were acutely treated by oral gavage with ferutinin, teferin and teferdin (2.5 mg/kg). Thereafter they were tested for: a) partner preference, b) receptivity, c) proceptivity, d) paced mating behaviour. In the partner preference test, the choice of the female for a sexually active male was not influenced by the different treatments. Similarly, during the paced mating test, the contact-return latencies as well as the percentage of exits from the male compartment were not different in control and treated rats. Therefore none of the three compounds showed the capacity to alter sexual motivation. On the other hand, ferutinin, but not teferin and teferdin, significantly inhibited female receptivity. These results suggest a primary role of ferutinin in the impairment of sexual behaviour elicited by Ferula hermonis extract in hormone primed-female rats.

Activity of single components of Ferula hermonis on male rat sexual behavior.
Int J Impot Res. 2005 Nov-Dec;17(6):513-8. Department of Pharmaceutical Sciences and National InterUniversity Consortium for the Study of Natural Active Principles (CINSPAN), University of Modena and Reggio Emilia, Modena, Italy.
The influence of the single components of Ferula hermonis extract zallouh on sexual behavior was studied in male rats. Sexually potent and sluggish/impotent animals were orally treated acutely (2.5 mg/kg) and subchronically (0.25 mg/kg/day for 10 days) with ferutinin, teferdin and teferin. Ferutinin alone acutely administered in potent rats was able to reduce mount and intromission latencies, while in sluggish/impotent animals, it induced the same effects and additionally shortened the ejaculation latency, as teferdin did. Both substances increased testosterone levels in rats. Unlike teferdin, ferutinin subchronically administered in potent rats negatively affected appetitive and consummatory sexual behavior, reducing also testosterone serum levels. In conclusion, if repetitively administered, ferutinin was able to stimulate sexual behavior after acute ingestion, but exerted a negative influence on the sexual capacity of potent male rats, whereas teferdin only improved copulatory performance of sluggish/impotent animals.

Sesquiterpene coumarins from Ferula szowitsiana and in vitro antileishmanial activity of 7-prenyloxycoumarins against promastigotes.
Phytochemistry. 2006 Dec 28; Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Mashhad, Iran.
Two new sesquiterpene coumarins, named szowitsiacoumarin A (1) and szowitsiacoumarin B (2), and a phenylpropanoid derivative, 2-epihelmanticine (3), together with nine known compounds, auraptene (4), umbelliprenin (5), galbanic acid (6), methyl galbanate (7), farnesiferol B (8), farnesiferol C (9), persicasulfide A (10), beta-sitosterol and stigmasterol were isolated from the roots of Ferula szowitsiana.
 

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